Successful Treatment of Fournier’s Gangrene in Child with Relapsed Acute Lymphoblastic Leukemia: Case Report and Review of the Literature
Julia Kołodziejczyk,1,* Jakub Czarny,1,* Stanisław Królak,1 Sandra Rutkowska,2 Sebastian Moryciński,3 Przemysław Mańkowski,3 Alicja Bartkowska-Śniatkowska,4 Jacek Wachowiak,2 Katarzyna Derwich,2 Olga Zając-Sp...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-04-01
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| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/successful-treatment-of-fourniers-gangrene-in-child-with-relapsed-acut-peer-reviewed-fulltext-article-IDR |
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| Summary: | Julia Kołodziejczyk,1,* Jakub Czarny,1,* Stanisław Królak,1 Sandra Rutkowska,2 Sebastian Moryciński,3 Przemysław Mańkowski,3 Alicja Bartkowska-Śniatkowska,4 Jacek Wachowiak,2 Katarzyna Derwich,2 Olga Zając-Spychała2 1Student Scientific Society, Poznan University of Medical Sciences, Poznan, Poland; 2Department of Pediatric Oncology, Hematology and Transplantology, Carol Jonscher’s Clinical Hospital, Poznan University of Medical Sciences, Poznan, Poland; 3Department of Pediatric Surgery, Traumatology and Urology, Carol Jonscher’s Clinical Hospital, Poznan University of Medical Sciences, Poznan, Poland; 4Department of Pediatric Anesthesiology and Intensive Therapy, Carol Jonscher’s Clinical Hospital, Poznan University of Medical Sciences, Poznan, Poland*These authors contributed equally to this workCorrespondence: Julia Kołodziejczyk, Student Scientific Society, Poznan University of Medical Sciences, Szpitalna Str. 27/33, 60-572, Poznan, Poland, Email 86066@student.ump.edu.plAbstract: Neutropenia associated with onco-hematological treatment may contribute to high-mortality infections, especially caused by multidrug-resistant pathogens. In a 4-year-old girl treated due to early isolated central nervous system (CNS) relapse of B-cell acute lymphoblastic leukemia, skin lesions with traits of Fournier’s gangrene caused by Klebsiella pneumoniae carbapenemase (KPC)-producing Pseudomonas aeruginosa (PsA). The patient was treated with broad-spectrum antibiotic therapy and the wound was debrided and treated with VAC (vacuum-assisted closure) successfully. Despite further intensive anticancer treatment complicated by reactivation of PsA infection, there was no other episode of invasive infection anymore and, nowadays, the patient has been in complete remission for 13 months. The aim of this report is to mention that Fournier’s gangrene is a rapid and potentially fatal infectious complication of chemotherapy in onco-hematological pediatric patients, especially if caused by MDR (multidrug-resistant) pathogens. Successful treatment of this necrotizing fasciitis saves a patient’s life and allows to continue an effective anticancer therapy.Keywords: Fournier’s gangrene, Pseudomonas aeruginosa, multidrug resistance, therapy, child, acute lymphoblastic leukemia |
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| ISSN: | 1178-6973 |