Toxicity and Dermatokinetic Analysis of Ibrutinib in Human Skin Models

Toxicity and Dermatokinetic Analysis of Ibrutinib in Human Skin Models

<b>Background/Objectives:</b> Ibrutinib (IBR) is a tyrosine kinase inhibitor under investigation in preclinical and clinical settings as an alternative treatment for melanoma. Nevertheless, the limited oral bioavailability of IBR and the need for high doses of the drug to kill melanoma c...

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Main Authors: Maria Victória Souto-Silva, Elizabete C. I. Bispo, Lucas F. F. Albuquerque, Stefhani Barcelos, Emãnuella M. Garcez, Luana S. Quilici, Florêncio Figueiredo Cavalcanti Neto, Eliza Carla Barroso Duarte, Jankerle N. Boeloni, Felipe Saldanha-Araujo, Guilherme M. Gelfuso, Juliana Lott Carvalho
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Pharmaceutics
Subjects:
hOSEC model
alternative models
melanoma
skin permeation
SKMEL-28
Online Access:https://www.mdpi.com/1999-4923/16/11/1377
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