A positive feedback loop between SMAD3 and PINK1 in regulation of mitophagy

A positive feedback loop between SMAD3 and PINK1 in regulation of mitophagy

Abstract PTEN-induced kinase-1 (PINK1) is a crucial player in selective clearance of damaged mitochondria via the autophagy-lysosome pathway, a process termed mitophagy. Previous studies on PINK1 mainly focused on its post-translational modifications, while the transcriptional regulation of PINK1 is...

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Main Authors: Mingzhu Tang, Dade Rong, Xiangzheng Gao, Guang Lu, Haimei Tang, Peng Wang, Ning-Yi Shao, Dajing Xia, Xin-Hua Feng, Wei-Feng He, Weilin Chen, Jia-Hong Lu, Wei Liu, Han-Ming Shen
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-025-00774-4
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