Presence of Aspartate Aminotransferase in Peri-Implant Crevicular Fluid with and without Mucositis
Background: Aspartate aminotransferase (AST) is an enzyme commonly found in various body fluids and tissues, including peri-implant crevicular fluid (PICF). Its presence and activity in PICF have been implicated in inflammatory conditions such as mucositis around dental implants. Materials and Metho...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_883_24 |
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| author | Priyanka Devadiya Yashika Goyal Divya Divya Jyoti Wasti Dipooja Patil Anamika Sinha Mahesh Ghadage |
| author_facet | Priyanka Devadiya Yashika Goyal Divya Divya Jyoti Wasti Dipooja Patil Anamika Sinha Mahesh Ghadage |
| author_sort | Priyanka Devadiya |
| collection | DOAJ |
| description | Background:
Aspartate aminotransferase (AST) is an enzyme commonly found in various body fluids and tissues, including peri-implant crevicular fluid (PICF). Its presence and activity in PICF have been implicated in inflammatory conditions such as mucositis around dental implants.
Materials and Methods:
This study aimed to compare the levels of AST in PICF collected from sites with mucositis (group A) and healthy sites (group B). PICF samples were collected using standardized paper strips and analyzed using enzymatic assays. The AST levels were quantified using a spectrophotometric method, and the data were statistically analyzed using Student’s t-test.
Results:
The mean AST level in group A (mucositis) was found to be 12.3 ± 2.1 U/mL, whereas in group B (healthy sites), it was significantly lower at 5.7 ± 1.3 U/mL (P < 0.05). These findings indicate a significant elevation of AST in PICF associated with mucositis compared to healthy peri-implant sites.
Conclusion:
Elevated levels of AST in PICF suggest its potential as a biomarker for detecting inflammatory conditions such as mucositis around dental implants. Monitoring AST levels in PICF could aid in the early detection and management of peri-implant diseases, contributing to improved clinical outcomes and implant longevity. |
| format | Article |
| id | doaj-art-a74f8e628fb74f11af82e0f6d726bff4 |
| institution | Kabale University |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-a74f8e628fb74f11af82e0f6d726bff42025-01-13T09:48:31ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062024-12-0116Suppl 4S3386S338810.4103/jpbs.jpbs_883_24Presence of Aspartate Aminotransferase in Peri-Implant Crevicular Fluid with and without MucositisPriyanka DevadiyaYashika GoyalDivya DivyaJyoti WastiDipooja PatilAnamika SinhaMahesh GhadageBackground: Aspartate aminotransferase (AST) is an enzyme commonly found in various body fluids and tissues, including peri-implant crevicular fluid (PICF). Its presence and activity in PICF have been implicated in inflammatory conditions such as mucositis around dental implants. Materials and Methods: This study aimed to compare the levels of AST in PICF collected from sites with mucositis (group A) and healthy sites (group B). PICF samples were collected using standardized paper strips and analyzed using enzymatic assays. The AST levels were quantified using a spectrophotometric method, and the data were statistically analyzed using Student’s t-test. Results: The mean AST level in group A (mucositis) was found to be 12.3 ± 2.1 U/mL, whereas in group B (healthy sites), it was significantly lower at 5.7 ± 1.3 U/mL (P < 0.05). These findings indicate a significant elevation of AST in PICF associated with mucositis compared to healthy peri-implant sites. Conclusion: Elevated levels of AST in PICF suggest its potential as a biomarker for detecting inflammatory conditions such as mucositis around dental implants. Monitoring AST levels in PICF could aid in the early detection and management of peri-implant diseases, contributing to improved clinical outcomes and implant longevity.https://journals.lww.com/10.4103/jpbs.jpbs_883_24aspartate aminotransferasebiomarkersdental implantsmucositisperi-implant crevicular fluid |
| spellingShingle | Priyanka Devadiya Yashika Goyal Divya Divya Jyoti Wasti Dipooja Patil Anamika Sinha Mahesh Ghadage Presence of Aspartate Aminotransferase in Peri-Implant Crevicular Fluid with and without Mucositis Journal of Pharmacy and Bioallied Sciences aspartate aminotransferase biomarkers dental implants mucositis peri-implant crevicular fluid |
| title | Presence of Aspartate Aminotransferase in Peri-Implant Crevicular Fluid with and without Mucositis |
| title_full | Presence of Aspartate Aminotransferase in Peri-Implant Crevicular Fluid with and without Mucositis |
| title_fullStr | Presence of Aspartate Aminotransferase in Peri-Implant Crevicular Fluid with and without Mucositis |
| title_full_unstemmed | Presence of Aspartate Aminotransferase in Peri-Implant Crevicular Fluid with and without Mucositis |
| title_short | Presence of Aspartate Aminotransferase in Peri-Implant Crevicular Fluid with and without Mucositis |
| title_sort | presence of aspartate aminotransferase in peri implant crevicular fluid with and without mucositis |
| topic | aspartate aminotransferase biomarkers dental implants mucositis peri-implant crevicular fluid |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_883_24 |
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