Ethyl acetate extract of Knoxia roxburghii (Rubiaceae) down-regulates ECHDC1, CAMK2D, DDB1, UBA6, BIRC6, and HK1 proteins and ameliorates the symptoms of diabetes mellitus

Ethyl acetate extract of Knoxia roxburghii (Rubiaceae) down-regulates ECHDC1, CAMK2D, DDB1, UBA6, BIRC6, and HK1 proteins and ameliorates the symptoms of diabetes mellitus

ObjectiveTo evaluate the effects of Knoxia roxburghii on blood glucose levels in diabetic rats and to investigate its underlying mechanisms of action using proteomics and metabolomics.MethodsStreptozotocin (STZ)-induced diabetic rats were treated with different doses of K. roxburghii extract. Proteo...

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Bibliographic Details
Main Authors: Xinge Wang, Xiaoqiao Tian, Yang Xu, Rong Li, Gusha Qumo, Jingping Li, Niman Bao, Maoru Li, Bin Qiu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
proteomics
metabolomics
diabetes
herb extract
PRM
oxidative
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1587858/full
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