Tea Polyphenols Regulate Key Mediators on Inflammatory Cardiovascular Diseases
Tea polyphenols known as catechins are key components with many biological functions, including anti-inflammatory, antioxidative, and anticarcinogenic effects. These effects are induced by the suppression of several inflammatory factors including nuclear factor-kappa B (NF-𝜅B). While these character...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2009/494928 |
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| _version_ | 1841524653979336704 |
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| author | Jun-ichi Suzuki Mitsuaki Isobe Ryuichi Morishita Ryozo Nagai |
| author_facet | Jun-ichi Suzuki Mitsuaki Isobe Ryuichi Morishita Ryozo Nagai |
| author_sort | Jun-ichi Suzuki |
| collection | DOAJ |
| description | Tea polyphenols known as catechins are key components with many biological functions, including anti-inflammatory, antioxidative, and anticarcinogenic effects. These effects are induced by the suppression of several inflammatory factors including nuclear factor-kappa B (NF-𝜅B). While these characteristics of catechins have been well documented, actions of catechins as mediators on inflammation-related cardiovascular diseases have not yet been well investigated. In this article, we reviewed recent papers to reveal the anti-inflammatory effects of catechins in cardiovascular diseases. In our laboratory, we performed oral administration of catechins into murine and rat models of cardiac transplantation, myocarditis, myocardial ischemia, and atherosclerosis to reveal the effects of catechins on the inflammation-induced ventricular and arterial remodeling. From our results, catechins are potent agents for the treatment and prevention of inflammation-related cardiovascular diseases because they are critically involved in the suppression of proinflammatory signaling pathways. |
| format | Article |
| id | doaj-art-a71b049d5af84fb899a2e3e37259a161 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-a71b049d5af84fb899a2e3e37259a1612025-02-03T05:47:48ZengWileyMediators of Inflammation0962-93511466-18612009-01-01200910.1155/2009/494928494928Tea Polyphenols Regulate Key Mediators on Inflammatory Cardiovascular DiseasesJun-ichi Suzuki0Mitsuaki Isobe1Ryuichi Morishita2Ryozo Nagai3Department of Advanced Clinical Science and Therapeutics, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, JapanDepartment of Cardiovascular Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, JapanDepartment of Clinical Gene Therapy, Osaka University, 2-2 Yamada-oka, Suita 565-0871, JapanDepartment of Cardiovascular Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, JapanTea polyphenols known as catechins are key components with many biological functions, including anti-inflammatory, antioxidative, and anticarcinogenic effects. These effects are induced by the suppression of several inflammatory factors including nuclear factor-kappa B (NF-𝜅B). While these characteristics of catechins have been well documented, actions of catechins as mediators on inflammation-related cardiovascular diseases have not yet been well investigated. In this article, we reviewed recent papers to reveal the anti-inflammatory effects of catechins in cardiovascular diseases. In our laboratory, we performed oral administration of catechins into murine and rat models of cardiac transplantation, myocarditis, myocardial ischemia, and atherosclerosis to reveal the effects of catechins on the inflammation-induced ventricular and arterial remodeling. From our results, catechins are potent agents for the treatment and prevention of inflammation-related cardiovascular diseases because they are critically involved in the suppression of proinflammatory signaling pathways.http://dx.doi.org/10.1155/2009/494928 |
| spellingShingle | Jun-ichi Suzuki Mitsuaki Isobe Ryuichi Morishita Ryozo Nagai Tea Polyphenols Regulate Key Mediators on Inflammatory Cardiovascular Diseases Mediators of Inflammation |
| title | Tea Polyphenols Regulate Key Mediators on Inflammatory Cardiovascular Diseases |
| title_full | Tea Polyphenols Regulate Key Mediators on Inflammatory Cardiovascular Diseases |
| title_fullStr | Tea Polyphenols Regulate Key Mediators on Inflammatory Cardiovascular Diseases |
| title_full_unstemmed | Tea Polyphenols Regulate Key Mediators on Inflammatory Cardiovascular Diseases |
| title_short | Tea Polyphenols Regulate Key Mediators on Inflammatory Cardiovascular Diseases |
| title_sort | tea polyphenols regulate key mediators on inflammatory cardiovascular diseases |
| url | http://dx.doi.org/10.1155/2009/494928 |
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