Development and pan-cancer validation of an epigenetics-based random survival forest model for prognosis prediction and drug response in OS

Development and pan-cancer validation of an epigenetics-based random survival forest model for prognosis prediction and drug response in OS

BackgroundOsteosarcoma (OS) exhibits significant epigenetic heterogeneity, yet its systematic characterization and clinical implications remain largely unexplored.MethodsWe analyzed single-cell transcriptomes of five primary OS samples, identifying cell type-specific epigenetic features and their ev...

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Bibliographic Details
Main Authors: Chaoyi Yin, Kede Chi, Zhiqing Chen, Shabin Zhuang, Yongsheng Ye, Binshan Zhang, Cailiang Cai
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
osteosarcoma
epigenetic heterogeneity
single-cell RNA sequencing
random survival forest
prognostic model
drug sensitivity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1529525/full
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