Despicable role of epithelial–mesenchymal transition in breast cancer metastasis: Exhibiting de novo restorative regimens
Breast cancer (BC) is the most prevalent cancer in women globally. Anti-cancer advancements have enabled the killing of BC cells through various therapies; however, cancer relapse is still a major limitation and decreases patient survival and quality of life. Epithelial-to-mesenchymal transition (EM...
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| Format: | Article |
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Elsevier
2025-01-01
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| Series: | Cancer Pathogenesis and Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949713224000016 |
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| author | Paras Famta Saurabh Shah Biswajit Dey Kondasingh Charan Kumar Deepkumar Bagasariya Ganesh Vambhurkar Giriraj Pandey Anamika Sharma Dadi A. Srinivasarao Rahul Kumar Santosh Kumar Guru Rajeev Singh Raghuvanshi Saurabh Srivastava |
| author_facet | Paras Famta Saurabh Shah Biswajit Dey Kondasingh Charan Kumar Deepkumar Bagasariya Ganesh Vambhurkar Giriraj Pandey Anamika Sharma Dadi A. Srinivasarao Rahul Kumar Santosh Kumar Guru Rajeev Singh Raghuvanshi Saurabh Srivastava |
| author_sort | Paras Famta |
| collection | DOAJ |
| description | Breast cancer (BC) is the most prevalent cancer in women globally. Anti-cancer advancements have enabled the killing of BC cells through various therapies; however, cancer relapse is still a major limitation and decreases patient survival and quality of life. Epithelial-to-mesenchymal transition (EMT) is responsible for tumor relapse in several cancers. This highly regulated event causes phenotypic, genetic, and epigenetic changes in the tumor microenvironment (TME). This review summarizes the recent advancements regarding EMT using de-differentiation and partial EMT theories. We extensively review the mechanistic pathways, TME components, and various anti-cancer adjuvant and neo-adjuvant therapies responsible for triggering EMT in BC tumors. Information regarding essential clinical studies and trials is also discussed. Furthermore, we also highlight the recent strategies targeting various EMT pathways. This review provides a holistic picture of BC biology, molecular pathways, and recent advances in therapeutic strategies. |
| format | Article |
| id | doaj-art-a70aa34e29e640e1a5c4b477c94fa633 |
| institution | Kabale University |
| issn | 2949-7132 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cancer Pathogenesis and Therapy |
| spelling | doaj-art-a70aa34e29e640e1a5c4b477c94fa6332025-01-06T04:09:10ZengElsevierCancer Pathogenesis and Therapy2949-71322025-01-01313047Despicable role of epithelial–mesenchymal transition in breast cancer metastasis: Exhibiting de novo restorative regimensParas Famta0Saurabh Shah1Biswajit Dey2Kondasingh Charan Kumar3Deepkumar Bagasariya4Ganesh Vambhurkar5Giriraj Pandey6Anamika Sharma7Dadi A. Srinivasarao8Rahul Kumar9Santosh Kumar Guru10Rajeev Singh Raghuvanshi11Saurabh Srivastava12Pharmaceutical Innovation and Translational Research Lab (PITRL), Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, 500037, IndiaPharmaceutical Innovation and Translational Research Lab (PITRL), Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, 500037, IndiaDepartment of Biological Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, IndiaPharmaceutical Innovation and Translational Research Lab (PITRL), Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, 500037, IndiaPharmaceutical Innovation and Translational Research Lab (PITRL), Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, 500037, IndiaPharmaceutical Innovation and Translational Research Lab (PITRL), Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, 500037, IndiaPharmaceutical Innovation and Translational Research Lab (PITRL), Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, 500037, IndiaDepartment of Biological Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, IndiaPharmaceutical Innovation and Translational Research Lab (PITRL), Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, 500037, IndiaDepartment of Biological Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, IndiaDepartment of Biological Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, IndiaCentral Drugs Standard Control Organization, Government of India, New Delhi, 110002 IndiaPharmaceutical Innovation and Translational Research Lab (PITRL), Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, 500037, India; Corresponding author: Pharmaceutical Innovation and Translational Research Lab (PITRL), Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, Telangana, 500037, India.Breast cancer (BC) is the most prevalent cancer in women globally. Anti-cancer advancements have enabled the killing of BC cells through various therapies; however, cancer relapse is still a major limitation and decreases patient survival and quality of life. Epithelial-to-mesenchymal transition (EMT) is responsible for tumor relapse in several cancers. This highly regulated event causes phenotypic, genetic, and epigenetic changes in the tumor microenvironment (TME). This review summarizes the recent advancements regarding EMT using de-differentiation and partial EMT theories. We extensively review the mechanistic pathways, TME components, and various anti-cancer adjuvant and neo-adjuvant therapies responsible for triggering EMT in BC tumors. Information regarding essential clinical studies and trials is also discussed. Furthermore, we also highlight the recent strategies targeting various EMT pathways. This review provides a holistic picture of BC biology, molecular pathways, and recent advances in therapeutic strategies.http://www.sciencedirect.com/science/article/pii/S2949713224000016Breast cancerEpithelial-to-mesenchymal transitionMetastasesCancer stem cellsEpigenetics |
| spellingShingle | Paras Famta Saurabh Shah Biswajit Dey Kondasingh Charan Kumar Deepkumar Bagasariya Ganesh Vambhurkar Giriraj Pandey Anamika Sharma Dadi A. Srinivasarao Rahul Kumar Santosh Kumar Guru Rajeev Singh Raghuvanshi Saurabh Srivastava Despicable role of epithelial–mesenchymal transition in breast cancer metastasis: Exhibiting de novo restorative regimens Cancer Pathogenesis and Therapy Breast cancer Epithelial-to-mesenchymal transition Metastases Cancer stem cells Epigenetics |
| title | Despicable role of epithelial–mesenchymal transition in breast cancer metastasis: Exhibiting de novo restorative regimens |
| title_full | Despicable role of epithelial–mesenchymal transition in breast cancer metastasis: Exhibiting de novo restorative regimens |
| title_fullStr | Despicable role of epithelial–mesenchymal transition in breast cancer metastasis: Exhibiting de novo restorative regimens |
| title_full_unstemmed | Despicable role of epithelial–mesenchymal transition in breast cancer metastasis: Exhibiting de novo restorative regimens |
| title_short | Despicable role of epithelial–mesenchymal transition in breast cancer metastasis: Exhibiting de novo restorative regimens |
| title_sort | despicable role of epithelial mesenchymal transition in breast cancer metastasis exhibiting de novo restorative regimens |
| topic | Breast cancer Epithelial-to-mesenchymal transition Metastases Cancer stem cells Epigenetics |
| url | http://www.sciencedirect.com/science/article/pii/S2949713224000016 |
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