Atrial APD prolongation caused by the upregulation of RAGE and subsequent I<sub>NaL</sub> increase in diabetic patients

Atrial APD prolongation caused by the upregulation of RAGE and subsequent I<sub>NaL</sub> increase in diabetic patients

Diabetes mellitus (DM) is a risk factor for the development of atrial fibrillation (AF). The action potential duration (APD) has been demonstrated to be prolonged in the atrium of diabetic mice. In contrast, the APD is generally shortened in AF patients. It is unclear what change occurs in the atria...

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Bibliographic Details
Main Authors: Luo Yingchun, Ma Wenbo, Kang Qi, Pan Han, Shi Ling, Ma Jiudong, Song Jiahui, Gong Dongmei, Kang Kai, Jin Xuexin
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2025-03-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
diabetes mellitus
receptor for advanced glycation end products (RAGE)
late sodium current
action potential duration
atrial fibrillation
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2025018
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