Oligonucleotide‐induced alternative splicing of serotonin 2C receptor reduces food intake

Oligonucleotide‐induced alternative splicing of serotonin 2C receptor reduces food intake

Abstract The serotonin 2C receptor regulates food uptake, and its activity is regulated by alternative pre‐mRNA splicing. Alternative exon skipping is predicted to generate a truncated receptor protein isoform, whose existence was confirmed with a new antiserum. The truncated receptor sequesters the...

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Bibliographic Details
Main Authors: Zhaiyi Zhang, Manli Shen, Paul J Gresch, Masoud Ghamari‐Langroudi, Alexander G Rabchevsky, Ronald B Emeson, Stefan Stamm
Format: Article
Language:English
Published: Springer Nature 2016-07-01
Series:EMBO Molecular Medicine
Subjects:
alternative splicing
brain function
food uptake
obesity
pre‐mRNA processing
Online Access:https://doi.org/10.15252/emmm.201506030
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https://doi.org/10.15252/emmm.201506030

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