A study of impulsivity and adverse childhood experiences in a population health setting
As complex mental health traits and life histories are often poorly captured in hospital systems, the utility of using the Barratt Impulsivity Scale (BIS) and Adverse Childhood Experiences (ACEs) for assessing adult disease risks is unknown. Here, we use participants from the Healthy Nevada Project...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1447008/full |
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| author | Robert W. Read Karen A. Schlauch Gai Elhanan Iva Neveux Stephanie Koning Takesha Cooper Takesha Cooper Joseph J. Grzymski Joseph J. Grzymski |
| author_facet | Robert W. Read Karen A. Schlauch Gai Elhanan Iva Neveux Stephanie Koning Takesha Cooper Takesha Cooper Joseph J. Grzymski Joseph J. Grzymski |
| author_sort | Robert W. Read |
| collection | DOAJ |
| description | As complex mental health traits and life histories are often poorly captured in hospital systems, the utility of using the Barratt Impulsivity Scale (BIS) and Adverse Childhood Experiences (ACEs) for assessing adult disease risks is unknown. Here, we use participants from the Healthy Nevada Project (HNP) to determine if two standard self-assessments could predict the incidence and onset of disease. We conducted a retrospective cohort study involving adult participants who completed the Behavioral and Mental Health Self-Assessment (HDSA) between September 2018 and March 2024. Impulsivity levels were measured using the BIS-15, and retrospective self-reports of ACEs were collected through a standardized questionnaire. In total, 17,482 HNP participants completed the HDSA. Our findings indicate that ACEs were significantly associated with impulsivity. Disease associations with impulsivity and ACEs were evaluated using a phenome-wide association study, identifying 230 significant associations with impulsivity. Among these, 44 were related to mental health diagnoses, including major depressive disorder (MDD). Kaplan–Meier survival estimates characterized the differences in the lifetime predicted probability between high and low impulsivity for major depressive disorder and essential hypertension. This analysis showed that having both high ACEs and high impulsivity confer substantial risk of MDD diagnosis (hazard ratios 2.81, 2.17, respectively). Additionally, lifetime predicted probability of MDD was approximately 40% higher for high ACEs and high impulsivity compared to no ACEs and low impulsivity. Essential hypertension demonstrated similar trends, with an approximate 20% increase in predicted lifetime probability of diagnosis. These results demonstrate that high ACES and elevated impulsivity scores are associated with a range of negative health outcomes and a simple self-assessment of complex traits and life history may significantly impact clinical risk assessments. |
| format | Article |
| id | doaj-art-a6d0a0e1b66744e79bf529dc6be15e35 |
| institution | Kabale University |
| issn | 2296-2565 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj-art-a6d0a0e1b66744e79bf529dc6be15e352025-01-09T12:53:48ZengFrontiers Media S.A.Frontiers in Public Health2296-25652024-12-011210.3389/fpubh.2024.14470081447008A study of impulsivity and adverse childhood experiences in a population health settingRobert W. Read0Karen A. Schlauch1Gai Elhanan2Iva Neveux3Stephanie Koning4Takesha Cooper5Takesha Cooper6Joseph J. Grzymski7Joseph J. Grzymski8Department of Internal Medicine, School of Medicine, University of Nevada, Reno, Reno, NV, United StatesDepartment of Internal Medicine, School of Medicine, University of Nevada, Reno, Reno, NV, United StatesDepartment of Internal Medicine, School of Medicine, University of Nevada, Reno, Reno, NV, United StatesDepartment of Internal Medicine, School of Medicine, University of Nevada, Reno, Reno, NV, United StatesDepartment of Health Behavior, Policy, and Administrative Sciences, School of Public Health, University of Nevada, Reno, Reno, NV, United StatesRenown Health, Reno, NV, United StatesDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of Nevada, Reno, Reno, NV, United StatesDepartment of Internal Medicine, School of Medicine, University of Nevada, Reno, Reno, NV, United StatesRenown Health, Reno, NV, United StatesAs complex mental health traits and life histories are often poorly captured in hospital systems, the utility of using the Barratt Impulsivity Scale (BIS) and Adverse Childhood Experiences (ACEs) for assessing adult disease risks is unknown. Here, we use participants from the Healthy Nevada Project (HNP) to determine if two standard self-assessments could predict the incidence and onset of disease. We conducted a retrospective cohort study involving adult participants who completed the Behavioral and Mental Health Self-Assessment (HDSA) between September 2018 and March 2024. Impulsivity levels were measured using the BIS-15, and retrospective self-reports of ACEs were collected through a standardized questionnaire. In total, 17,482 HNP participants completed the HDSA. Our findings indicate that ACEs were significantly associated with impulsivity. Disease associations with impulsivity and ACEs were evaluated using a phenome-wide association study, identifying 230 significant associations with impulsivity. Among these, 44 were related to mental health diagnoses, including major depressive disorder (MDD). Kaplan–Meier survival estimates characterized the differences in the lifetime predicted probability between high and low impulsivity for major depressive disorder and essential hypertension. This analysis showed that having both high ACEs and high impulsivity confer substantial risk of MDD diagnosis (hazard ratios 2.81, 2.17, respectively). Additionally, lifetime predicted probability of MDD was approximately 40% higher for high ACEs and high impulsivity compared to no ACEs and low impulsivity. Essential hypertension demonstrated similar trends, with an approximate 20% increase in predicted lifetime probability of diagnosis. These results demonstrate that high ACES and elevated impulsivity scores are associated with a range of negative health outcomes and a simple self-assessment of complex traits and life history may significantly impact clinical risk assessments.https://www.frontiersin.org/articles/10.3389/fpubh.2024.1447008/fullpublic mental healthimpulsivityadverse childhood experiencessocial determinants of healthPheWASKaplan–Meier analyses |
| spellingShingle | Robert W. Read Karen A. Schlauch Gai Elhanan Iva Neveux Stephanie Koning Takesha Cooper Takesha Cooper Joseph J. Grzymski Joseph J. Grzymski A study of impulsivity and adverse childhood experiences in a population health setting Frontiers in Public Health public mental health impulsivity adverse childhood experiences social determinants of health PheWAS Kaplan–Meier analyses |
| title | A study of impulsivity and adverse childhood experiences in a population health setting |
| title_full | A study of impulsivity and adverse childhood experiences in a population health setting |
| title_fullStr | A study of impulsivity and adverse childhood experiences in a population health setting |
| title_full_unstemmed | A study of impulsivity and adverse childhood experiences in a population health setting |
| title_short | A study of impulsivity and adverse childhood experiences in a population health setting |
| title_sort | study of impulsivity and adverse childhood experiences in a population health setting |
| topic | public mental health impulsivity adverse childhood experiences social determinants of health PheWAS Kaplan–Meier analyses |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1447008/full |
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