Mosquito-independent milk-associated transmission of zoonotic Wesselsbron virus in sheep.

Wesselsbron virus (WSLV) is a zoonotic, mosquito-borne orthoflavivirus endemic to sub-Saharan Africa, causing abortions and stillbirths in small ruminants. The life cycle of WSLV involves Aedes mosquitoes and various wildlife and domestic animals. Seminal studies in the 1950s have shown the zoonotic...

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Main Authors: Marta Zimoch, Llorenç Grau-Roma, Matthias Liniger, Noelle Donzé, Aurélie Godel, Damián Escribano, Bettina Salome Trüeb, Paraskevi Pramateftaki, Sergi Torres-Puig, José Joaqín Cerón, Volker Thiel, Jörg Jores, Artur Summerfield, Nicolas Ruggli, Charaf Benarafa, Obdulio García-Nicolás
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012751
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author Marta Zimoch
Llorenç Grau-Roma
Matthias Liniger
Noelle Donzé
Aurélie Godel
Damián Escribano
Bettina Salome Trüeb
Paraskevi Pramateftaki
Sergi Torres-Puig
José Joaqín Cerón
Volker Thiel
Jörg Jores
Artur Summerfield
Nicolas Ruggli
Charaf Benarafa
Obdulio García-Nicolás
author_facet Marta Zimoch
Llorenç Grau-Roma
Matthias Liniger
Noelle Donzé
Aurélie Godel
Damián Escribano
Bettina Salome Trüeb
Paraskevi Pramateftaki
Sergi Torres-Puig
José Joaqín Cerón
Volker Thiel
Jörg Jores
Artur Summerfield
Nicolas Ruggli
Charaf Benarafa
Obdulio García-Nicolás
author_sort Marta Zimoch
collection DOAJ
description Wesselsbron virus (WSLV) is a zoonotic, mosquito-borne orthoflavivirus endemic to sub-Saharan Africa, causing abortions and stillbirths in small ruminants. The life cycle of WSLV involves Aedes mosquitoes and various wildlife and domestic animals. Seminal studies in the 1950s have shown the zoonotic potential of WSLV, notably in accidental infections of laboratory workers exposed to infected material. More recent epidemiological studies suggest the emergence of clade I WSLV strains in peri-domestic and rural areas of western and eastern Africa. The pathobiology of recent clade I WSLV strains is unknown and no virus isolate is available. To address these gaps, we generated a recombinant clade I WSLV SA999 infectious clone (rSA999) by reverse genetics. Subsequently, lactating ewes were inoculated intravenously with the WSLV rSA999 strain or the clade II SAH177 strain in insect-free biocontainment stables. Inoculated ewes developed fever, viremia, and showed high levels of viral RNA at mucosal surfaces, and elevated viral titers in milk. Milk production was reduced, which directly affected the growth of the lambs, particularly within the rSA999 group. The ewes with higher WSLV titers in their milk in each group transmitted the infection to their lambs, which developed fever, prolonged viremia, and virus secretion. All infected animals produced high antibody titers with cross-neutralizing activity against both WSLV strains. Histopathology and blood biochemistry analysis indicated liver damage associated with necrotizing hepatitis lesions and active viral replication in some cases, which was more pronounced in the rSA999 group. Notably, only the SAH177-infected animals exhibited lesions consistent with meningoencephalitis, suggesting that WSLV clade II strains are neurotropic and that clade I strain are more hepatotropic. These findings demonstrate a previously unrecognized mode of vector-free transmission of WSLV that raises significant concerns for public and animal health.
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institution Kabale University
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spelling doaj-art-a6bbc2e2f8ba49e085b9033b2719e54d2025-01-10T05:31:47ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742024-12-012012e101275110.1371/journal.ppat.1012751Mosquito-independent milk-associated transmission of zoonotic Wesselsbron virus in sheep.Marta ZimochLlorenç Grau-RomaMatthias LinigerNoelle DonzéAurélie GodelDamián EscribanoBettina Salome TrüebParaskevi PramateftakiSergi Torres-PuigJosé Joaqín CerónVolker ThielJörg JoresArtur SummerfieldNicolas RuggliCharaf BenarafaObdulio García-NicolásWesselsbron virus (WSLV) is a zoonotic, mosquito-borne orthoflavivirus endemic to sub-Saharan Africa, causing abortions and stillbirths in small ruminants. The life cycle of WSLV involves Aedes mosquitoes and various wildlife and domestic animals. Seminal studies in the 1950s have shown the zoonotic potential of WSLV, notably in accidental infections of laboratory workers exposed to infected material. More recent epidemiological studies suggest the emergence of clade I WSLV strains in peri-domestic and rural areas of western and eastern Africa. The pathobiology of recent clade I WSLV strains is unknown and no virus isolate is available. To address these gaps, we generated a recombinant clade I WSLV SA999 infectious clone (rSA999) by reverse genetics. Subsequently, lactating ewes were inoculated intravenously with the WSLV rSA999 strain or the clade II SAH177 strain in insect-free biocontainment stables. Inoculated ewes developed fever, viremia, and showed high levels of viral RNA at mucosal surfaces, and elevated viral titers in milk. Milk production was reduced, which directly affected the growth of the lambs, particularly within the rSA999 group. The ewes with higher WSLV titers in their milk in each group transmitted the infection to their lambs, which developed fever, prolonged viremia, and virus secretion. All infected animals produced high antibody titers with cross-neutralizing activity against both WSLV strains. Histopathology and blood biochemistry analysis indicated liver damage associated with necrotizing hepatitis lesions and active viral replication in some cases, which was more pronounced in the rSA999 group. Notably, only the SAH177-infected animals exhibited lesions consistent with meningoencephalitis, suggesting that WSLV clade II strains are neurotropic and that clade I strain are more hepatotropic. These findings demonstrate a previously unrecognized mode of vector-free transmission of WSLV that raises significant concerns for public and animal health.https://doi.org/10.1371/journal.ppat.1012751
spellingShingle Marta Zimoch
Llorenç Grau-Roma
Matthias Liniger
Noelle Donzé
Aurélie Godel
Damián Escribano
Bettina Salome Trüeb
Paraskevi Pramateftaki
Sergi Torres-Puig
José Joaqín Cerón
Volker Thiel
Jörg Jores
Artur Summerfield
Nicolas Ruggli
Charaf Benarafa
Obdulio García-Nicolás
Mosquito-independent milk-associated transmission of zoonotic Wesselsbron virus in sheep.
PLoS Pathogens
title Mosquito-independent milk-associated transmission of zoonotic Wesselsbron virus in sheep.
title_full Mosquito-independent milk-associated transmission of zoonotic Wesselsbron virus in sheep.
title_fullStr Mosquito-independent milk-associated transmission of zoonotic Wesselsbron virus in sheep.
title_full_unstemmed Mosquito-independent milk-associated transmission of zoonotic Wesselsbron virus in sheep.
title_short Mosquito-independent milk-associated transmission of zoonotic Wesselsbron virus in sheep.
title_sort mosquito independent milk associated transmission of zoonotic wesselsbron virus in sheep
url https://doi.org/10.1371/journal.ppat.1012751
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