Predictive value of creatinine-cystatin C ratio for mortality and technique failure in anuric peritoneal dialysis patients
Objectives Both serum creatinine and cystatin C serve as dependable markers of renal function and have demonstrated a correlation with clinical outcomes in diverse conditions, particularly through the ratio of creatinine to cystatin C (Cr/CysC). Anuric patients undergoing peritoneal dialysis (PD) de...
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| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2444389 |
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| author | Zhihong Zhang Tingting Zhou Man Zhang Shuiqin Cheng |
| author_facet | Zhihong Zhang Tingting Zhou Man Zhang Shuiqin Cheng |
| author_sort | Zhihong Zhang |
| collection | DOAJ |
| description | Objectives Both serum creatinine and cystatin C serve as dependable markers of renal function and have demonstrated a correlation with clinical outcomes in diverse conditions, particularly through the ratio of creatinine to cystatin C (Cr/CysC). Anuric patients undergoing peritoneal dialysis (PD) depend entirely on the clearance of peritoneal solutes. This research posits that the Cr/CysC ratio may predict all-cause mortality and technique failure in anuric PD patients.Methods A cohort of 224 anuric PD patients was recruited from January 1, 2014, to December 31, 2019, with follow-up extending until December 31, 2023. The Cr/CysC ratio was computed by dividing the serum creatinine concentration by the cystatin C concentration obtained on the same day. We evaluated the relationship between the Cr/CysC ratio and patient survival, as well as technique failure, utilizing Cox regression and competing risk analyses.Results The average age of the participants was 50.46 ± 12.63 years, with 99 individuals (44.2%) being male. Among all subjects, the Cr/CysC ratio was found to be 1.85 ± 0.56. After controlling for potential confounders, Cox proportional hazards models revealed that the Cr/CysC ratio was significantly linked to the risk of all-cause mortality and technique failure (HR = 0.330, 95% CI 0.124-0.881, p = 0.027; HR = 0.440, 95% CI 0.267-0.726, p = 0.002). Importantly, the significant associations observed in the Cox regression analysis persisted even after accounting for competing risks.Conclusion The Cr/CysC ratio at baseline was recognized as an independent predictor of all-cause mortality and technique failure in anuric PD patients. |
| format | Article |
| id | doaj-art-a6a757c0ff0444aa8127e8b73c53b917 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-a6a757c0ff0444aa8127e8b73c53b9172025-01-03T02:14:47ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492025-12-0147110.1080/0886022X.2024.2444389Predictive value of creatinine-cystatin C ratio for mortality and technique failure in anuric peritoneal dialysis patientsZhihong Zhang0Tingting Zhou1Man Zhang2Shuiqin Cheng3National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, ChinaNational Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, ChinaNational Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, ChinaNational Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, ChinaObjectives Both serum creatinine and cystatin C serve as dependable markers of renal function and have demonstrated a correlation with clinical outcomes in diverse conditions, particularly through the ratio of creatinine to cystatin C (Cr/CysC). Anuric patients undergoing peritoneal dialysis (PD) depend entirely on the clearance of peritoneal solutes. This research posits that the Cr/CysC ratio may predict all-cause mortality and technique failure in anuric PD patients.Methods A cohort of 224 anuric PD patients was recruited from January 1, 2014, to December 31, 2019, with follow-up extending until December 31, 2023. The Cr/CysC ratio was computed by dividing the serum creatinine concentration by the cystatin C concentration obtained on the same day. We evaluated the relationship between the Cr/CysC ratio and patient survival, as well as technique failure, utilizing Cox regression and competing risk analyses.Results The average age of the participants was 50.46 ± 12.63 years, with 99 individuals (44.2%) being male. Among all subjects, the Cr/CysC ratio was found to be 1.85 ± 0.56. After controlling for potential confounders, Cox proportional hazards models revealed that the Cr/CysC ratio was significantly linked to the risk of all-cause mortality and technique failure (HR = 0.330, 95% CI 0.124-0.881, p = 0.027; HR = 0.440, 95% CI 0.267-0.726, p = 0.002). Importantly, the significant associations observed in the Cox regression analysis persisted even after accounting for competing risks.Conclusion The Cr/CysC ratio at baseline was recognized as an independent predictor of all-cause mortality and technique failure in anuric PD patients.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2444389Peritoneal dialysisdeathtechnique failureratio of creatinine to cystatin C |
| spellingShingle | Zhihong Zhang Tingting Zhou Man Zhang Shuiqin Cheng Predictive value of creatinine-cystatin C ratio for mortality and technique failure in anuric peritoneal dialysis patients Renal Failure Peritoneal dialysis death technique failure ratio of creatinine to cystatin C |
| title | Predictive value of creatinine-cystatin C ratio for mortality and technique failure in anuric peritoneal dialysis patients |
| title_full | Predictive value of creatinine-cystatin C ratio for mortality and technique failure in anuric peritoneal dialysis patients |
| title_fullStr | Predictive value of creatinine-cystatin C ratio for mortality and technique failure in anuric peritoneal dialysis patients |
| title_full_unstemmed | Predictive value of creatinine-cystatin C ratio for mortality and technique failure in anuric peritoneal dialysis patients |
| title_short | Predictive value of creatinine-cystatin C ratio for mortality and technique failure in anuric peritoneal dialysis patients |
| title_sort | predictive value of creatinine cystatin c ratio for mortality and technique failure in anuric peritoneal dialysis patients |
| topic | Peritoneal dialysis death technique failure ratio of creatinine to cystatin C |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2444389 |
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