E3 ubiquitination ligase XIAP lightens diabetes‐induced cognitive impairment by inactivating TXNIP‐ERS‐mediated neuronal injury
Abstract Diabetes‐induced cognitive dysfunction (DCD) is a neurological disorder associated with diabetes, characterized by cognitive impairment driven by neuronal injury from chronic high glucose (HG) exposure. This study aims to elucidate the role and mechanisms of the X‐linked inhibitor of apopto...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Kaohsiung Journal of Medical Sciences |
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| Online Access: | https://doi.org/10.1002/kjm2.12913 |
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| author | Qin Zhang Hai‐Jin Huang Jing‐Ling Zhang Ying Tian Ying Hu |
| author_facet | Qin Zhang Hai‐Jin Huang Jing‐Ling Zhang Ying Tian Ying Hu |
| author_sort | Qin Zhang |
| collection | DOAJ |
| description | Abstract Diabetes‐induced cognitive dysfunction (DCD) is a neurological disorder associated with diabetes, characterized by cognitive impairment driven by neuronal injury from chronic high glucose (HG) exposure. This study aims to elucidate the role and mechanisms of the X‐linked inhibitor of apoptosis protein (XIAP)/thioredoxin‐interacting protein (TXNIP) in hippocampal neuron cell death and cognitive function within DCD models. A diabetic rat model was established using a high‐fat/sucrose diet and streptozotocin injection. Primary hippocampal neurons were stimulated with HG to mimic diabetic conditions. Cognitive and memory functions were assessed using the Morris water maze (MWM) and novel object recognition test (ORT). |
| format | Article |
| id | doaj-art-a68bf7ebf48c45a7aa2bd322e3ec1f38 |
| institution | Kabale University |
| issn | 1607-551X 2410-8650 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj-art-a68bf7ebf48c45a7aa2bd322e3ec1f382025-01-11T05:35:55ZengWileyKaohsiung Journal of Medical Sciences1607-551X2410-86502025-01-01411n/an/a10.1002/kjm2.12913E3 ubiquitination ligase XIAP lightens diabetes‐induced cognitive impairment by inactivating TXNIP‐ERS‐mediated neuronal injuryQin Zhang0Hai‐Jin Huang1Jing‐Ling Zhang2Ying Tian3Ying Hu4Department of Anesthesiology and Operative Medicine, Medical Center of Anesthesiology and Pain, the 1st Affiliated Hospital, Jiangxi Medical College Nanchang University Nanchang Jiangxi Province PR ChinaDepartment of Anesthesiology and Operative Medicine, Medical Center of Anesthesiology and Pain, the 1st Affiliated Hospital, Jiangxi Medical College Nanchang University Nanchang Jiangxi Province PR ChinaDepartment of Anesthesiology and Operative Medicine, Medical Center of Anesthesiology and Pain, the 1st Affiliated Hospital, Jiangxi Medical College Nanchang University Nanchang Jiangxi Province PR ChinaDepartment of Anesthesiology and Operative Medicine, Medical Center of Anesthesiology and Pain, the 1st Affiliated Hospital, Jiangxi Medical College Nanchang University Nanchang Jiangxi Province PR ChinaDepartment of Endocrinology and Metabolism, the 1st Affiliated Hospital, Jiangxi Medical College Nanchang University Nanchang Jiangxi Province PR ChinaAbstract Diabetes‐induced cognitive dysfunction (DCD) is a neurological disorder associated with diabetes, characterized by cognitive impairment driven by neuronal injury from chronic high glucose (HG) exposure. This study aims to elucidate the role and mechanisms of the X‐linked inhibitor of apoptosis protein (XIAP)/thioredoxin‐interacting protein (TXNIP) in hippocampal neuron cell death and cognitive function within DCD models. A diabetic rat model was established using a high‐fat/sucrose diet and streptozotocin injection. Primary hippocampal neurons were stimulated with HG to mimic diabetic conditions. Cognitive and memory functions were assessed using the Morris water maze (MWM) and novel object recognition test (ORT).https://doi.org/10.1002/kjm2.12913diabetes‐induced cognitive dysfunctionendoplasmic reticulum stressTXNIPXIAP |
| spellingShingle | Qin Zhang Hai‐Jin Huang Jing‐Ling Zhang Ying Tian Ying Hu E3 ubiquitination ligase XIAP lightens diabetes‐induced cognitive impairment by inactivating TXNIP‐ERS‐mediated neuronal injury Kaohsiung Journal of Medical Sciences diabetes‐induced cognitive dysfunction endoplasmic reticulum stress TXNIP XIAP |
| title | E3 ubiquitination ligase XIAP lightens diabetes‐induced cognitive impairment by inactivating TXNIP‐ERS‐mediated neuronal injury |
| title_full | E3 ubiquitination ligase XIAP lightens diabetes‐induced cognitive impairment by inactivating TXNIP‐ERS‐mediated neuronal injury |
| title_fullStr | E3 ubiquitination ligase XIAP lightens diabetes‐induced cognitive impairment by inactivating TXNIP‐ERS‐mediated neuronal injury |
| title_full_unstemmed | E3 ubiquitination ligase XIAP lightens diabetes‐induced cognitive impairment by inactivating TXNIP‐ERS‐mediated neuronal injury |
| title_short | E3 ubiquitination ligase XIAP lightens diabetes‐induced cognitive impairment by inactivating TXNIP‐ERS‐mediated neuronal injury |
| title_sort | e3 ubiquitination ligase xiap lightens diabetes induced cognitive impairment by inactivating txnip ers mediated neuronal injury |
| topic | diabetes‐induced cognitive dysfunction endoplasmic reticulum stress TXNIP XIAP |
| url | https://doi.org/10.1002/kjm2.12913 |
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