PdRu bimetallic nanoalloys with improved photothermal effect for amplified ROS-mediated tumor therapy
An emerging strategy in cancer therapy involves inducing reactive oxygen species (ROS), specifically within tumors using nanozymes. However, existing nanozymes suffer from limitations such as low reactivity, poor biocompatibility, and limited targeting capabilities, hindering their therapeutic effic...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1523599/full |
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| author | Yujia Liang Shufang Ning Mekhrdod S. Kurboniyon Khaiyom Rahmonov Zhengmin Cai Shirong Li Jinling Mai Xiaojing He Lijuan Liu Liping Tang Litu Zhang Chen Wang |
| author_facet | Yujia Liang Shufang Ning Mekhrdod S. Kurboniyon Khaiyom Rahmonov Zhengmin Cai Shirong Li Jinling Mai Xiaojing He Lijuan Liu Liping Tang Litu Zhang Chen Wang |
| author_sort | Yujia Liang |
| collection | DOAJ |
| description | An emerging strategy in cancer therapy involves inducing reactive oxygen species (ROS), specifically within tumors using nanozymes. However, existing nanozymes suffer from limitations such as low reactivity, poor biocompatibility, and limited targeting capabilities, hindering their therapeutic efficacy. In response, the PdRu@PEI bimetallic nanoalloys were constructed with well-catalytic activities and effective separation of charges, which can catalyze hydrogen peroxide (H2O2) to toxic hydroxyl radical (·OH) under near-infrared laser stimulation. Through facilitating electron transfer and enhancing active sites, the enhanced peroxidase-like (POD-like) enzymatic activity and glutathione (GSH) depletion abilities of nanozymes are boosted through a simple co-reduction process, leading to promising anti-tumor activity. The electron transfer between Pd and Ru of PdRu@PEI nanoalloys contributes to POD-like activity. Then, by oxidizing endogenous overexpressed GSH, enzymatic cycling prevents GSH from consuming ROS. Furthermore, the surface plasmon resonance effect of near-infrared laser on bimetallic nanoalloys ensures its photothermal performance and its local heating, further promoting POD-like activity. The integrated multi-modal therapeutic approach of PdRu@PEI has demonstrated significant anti-cancer effects in vivo studies. The nanozymes exhibit high catalytic efficiency and excellent biocompatibility, offering valuable insights for the development of nano-catalysts/enzymes for biomedical applications. |
| format | Article |
| id | doaj-art-a6817d0129594074bb83b4a9dde228f1 |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-a6817d0129594074bb83b4a9dde228f12025-01-03T06:47:14ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-01-011210.3389/fbioe.2024.15235991523599PdRu bimetallic nanoalloys with improved photothermal effect for amplified ROS-mediated tumor therapyYujia Liang0Shufang Ning1Mekhrdod S. Kurboniyon2Khaiyom Rahmonov3Zhengmin Cai4Shirong Li5Jinling Mai6Xiaojing He7Lijuan Liu8Liping Tang9Litu Zhang10Chen Wang11Department of Experimental Research and Guangxi Cancer Molecular Medicine Engineering Research Center and Guangxi Key Laboratory of Basic and Translational Research for Colorectal Cancer, Guangxi Medical University Cancer Hospital, Nanning, ChinaDepartment of Experimental Research and Guangxi Cancer Molecular Medicine Engineering Research Center and Guangxi Key Laboratory of Basic and Translational Research for Colorectal Cancer, Guangxi Medical University Cancer Hospital, Nanning, ChinaNational Academy of Sciences of Tajikistan, Dushanbe, TajikistanNational Academy of Sciences of Tajikistan, Dushanbe, TajikistanDepartment of Experimental Research and Guangxi Cancer Molecular Medicine Engineering Research Center and Guangxi Key Laboratory of Basic and Translational Research for Colorectal Cancer, Guangxi Medical University Cancer Hospital, Nanning, ChinaDepartment of Experimental Research and Guangxi Cancer Molecular Medicine Engineering Research Center and Guangxi Key Laboratory of Basic and Translational Research for Colorectal Cancer, Guangxi Medical University Cancer Hospital, Nanning, ChinaDepartment of Experimental Research and Guangxi Cancer Molecular Medicine Engineering Research Center and Guangxi Key Laboratory of Basic and Translational Research for Colorectal Cancer, Guangxi Medical University Cancer Hospital, Nanning, ChinaDepartment of Experimental Research and Guangxi Cancer Molecular Medicine Engineering Research Center and Guangxi Key Laboratory of Basic and Translational Research for Colorectal Cancer, Guangxi Medical University Cancer Hospital, Nanning, ChinaDepartment of Experimental Research and Guangxi Cancer Molecular Medicine Engineering Research Center and Guangxi Key Laboratory of Basic and Translational Research for Colorectal Cancer, Guangxi Medical University Cancer Hospital, Nanning, ChinaDepartment of Information, Library of Guangxi Medical University, Nanning, ChinaDepartment of Experimental Research and Guangxi Cancer Molecular Medicine Engineering Research Center and Guangxi Key Laboratory of Basic and Translational Research for Colorectal Cancer, Guangxi Medical University Cancer Hospital, Nanning, ChinaDepartment of Experimental Research and Guangxi Cancer Molecular Medicine Engineering Research Center and Guangxi Key Laboratory of Basic and Translational Research for Colorectal Cancer, Guangxi Medical University Cancer Hospital, Nanning, ChinaAn emerging strategy in cancer therapy involves inducing reactive oxygen species (ROS), specifically within tumors using nanozymes. However, existing nanozymes suffer from limitations such as low reactivity, poor biocompatibility, and limited targeting capabilities, hindering their therapeutic efficacy. In response, the PdRu@PEI bimetallic nanoalloys were constructed with well-catalytic activities and effective separation of charges, which can catalyze hydrogen peroxide (H2O2) to toxic hydroxyl radical (·OH) under near-infrared laser stimulation. Through facilitating electron transfer and enhancing active sites, the enhanced peroxidase-like (POD-like) enzymatic activity and glutathione (GSH) depletion abilities of nanozymes are boosted through a simple co-reduction process, leading to promising anti-tumor activity. The electron transfer between Pd and Ru of PdRu@PEI nanoalloys contributes to POD-like activity. Then, by oxidizing endogenous overexpressed GSH, enzymatic cycling prevents GSH from consuming ROS. Furthermore, the surface plasmon resonance effect of near-infrared laser on bimetallic nanoalloys ensures its photothermal performance and its local heating, further promoting POD-like activity. The integrated multi-modal therapeutic approach of PdRu@PEI has demonstrated significant anti-cancer effects in vivo studies. The nanozymes exhibit high catalytic efficiency and excellent biocompatibility, offering valuable insights for the development of nano-catalysts/enzymes for biomedical applications.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1523599/fullnanoalloyreactive oxygen speciesglutathionephotothermal effecttumor therapy |
| spellingShingle | Yujia Liang Shufang Ning Mekhrdod S. Kurboniyon Khaiyom Rahmonov Zhengmin Cai Shirong Li Jinling Mai Xiaojing He Lijuan Liu Liping Tang Litu Zhang Chen Wang PdRu bimetallic nanoalloys with improved photothermal effect for amplified ROS-mediated tumor therapy Frontiers in Bioengineering and Biotechnology nanoalloy reactive oxygen species glutathione photothermal effect tumor therapy |
| title | PdRu bimetallic nanoalloys with improved photothermal effect for amplified ROS-mediated tumor therapy |
| title_full | PdRu bimetallic nanoalloys with improved photothermal effect for amplified ROS-mediated tumor therapy |
| title_fullStr | PdRu bimetallic nanoalloys with improved photothermal effect for amplified ROS-mediated tumor therapy |
| title_full_unstemmed | PdRu bimetallic nanoalloys with improved photothermal effect for amplified ROS-mediated tumor therapy |
| title_short | PdRu bimetallic nanoalloys with improved photothermal effect for amplified ROS-mediated tumor therapy |
| title_sort | pdru bimetallic nanoalloys with improved photothermal effect for amplified ros mediated tumor therapy |
| topic | nanoalloy reactive oxygen species glutathione photothermal effect tumor therapy |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1523599/full |
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