Chitinase 3‐like 1 overexpression aggravates hypoxia–reoxygenation injury in IEC‐6 cells by inhibiting the PI3K/AKT signalling pathway

Chitinase 3‐like 1 overexpression aggravates hypoxia–reoxygenation injury in IEC‐6 cells by inhibiting the PI3K/AKT signalling pathway

Abstract Intestinal ischaemia–reperfusion (I/R) is a common clinical pathology with high incidence and mortality rates. However, the mechanisms underlying intestinal I/R injury remain unclear. In this study, we investigated the role and mechanism of chitinase 3‐like 1 (CHI3L1) during intestinal I/R...

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Bibliographic Details
Main Authors: Lei Mi, Jie Jin, Yingying Zhang, Ming Chen, JianLi Cui, Rui Chen, Xiao Zheng, Changqing Jing
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Experimental Physiology
Subjects:
CHI3L1
intestinal ischaemia–reperfusion
NF‐κB
Nrf2
nuclear translocation
PI3K/AKT
Online Access:https://doi.org/10.1113/EP091768
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