SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models
Type 2 diabetes mellitus is a complex age-related metabolic disease. Cognitive dysfunction and learning and memory deficits are main characteristics of age-related metabolic diseases in the central nervous system. The underlying mechanisms contributing to cognitive decline are complex, especially co...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/7121827 |
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| author | Yue Cao Zi Yan Tong Zhou Guixia Wang |
| author_facet | Yue Cao Zi Yan Tong Zhou Guixia Wang |
| author_sort | Yue Cao |
| collection | DOAJ |
| description | Type 2 diabetes mellitus is a complex age-related metabolic disease. Cognitive dysfunction and learning and memory deficits are main characteristics of age-related metabolic diseases in the central nervous system. The underlying mechanisms contributing to cognitive decline are complex, especially cognitive dysfunction associated with type 2 diabetes mellitus. SIRT1, as one of the modulators in insulin resistance, is indispensable for learning and memory. In the present study, deacetylation, oxidative stress, mitochondrial dysfunction, inflammation, microRNA, and tau phosphorylation are considered in the context of mechanism and significance of SIRT1 in learning and memory in diabetic and nondiabetic murine models. In addition, future research directions in this field are discussed, including therapeutic potential of its activator, resveratrol, and application of other compounds in cognitive improvement. Our findings suggest that SIRT1 might be a potential therapeutic target for the treatment of cognitive impairment induced by type 2 diabetes mellitus. |
| format | Article |
| id | doaj-art-a66eaedfb01e4d498fae8b08bbad05f0 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-a66eaedfb01e4d498fae8b08bbad05f02025-02-03T05:47:41ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/71218277121827SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic ModelsYue Cao0Zi Yan1Tong Zhou2Guixia Wang3Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, Jilin, ChinaType 2 diabetes mellitus is a complex age-related metabolic disease. Cognitive dysfunction and learning and memory deficits are main characteristics of age-related metabolic diseases in the central nervous system. The underlying mechanisms contributing to cognitive decline are complex, especially cognitive dysfunction associated with type 2 diabetes mellitus. SIRT1, as one of the modulators in insulin resistance, is indispensable for learning and memory. In the present study, deacetylation, oxidative stress, mitochondrial dysfunction, inflammation, microRNA, and tau phosphorylation are considered in the context of mechanism and significance of SIRT1 in learning and memory in diabetic and nondiabetic murine models. In addition, future research directions in this field are discussed, including therapeutic potential of its activator, resveratrol, and application of other compounds in cognitive improvement. Our findings suggest that SIRT1 might be a potential therapeutic target for the treatment of cognitive impairment induced by type 2 diabetes mellitus.http://dx.doi.org/10.1155/2017/7121827 |
| spellingShingle | Yue Cao Zi Yan Tong Zhou Guixia Wang SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models Journal of Diabetes Research |
| title | SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models |
| title_full | SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models |
| title_fullStr | SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models |
| title_full_unstemmed | SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models |
| title_short | SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models |
| title_sort | sirt1 regulates cognitive performance and ability of learning and memory in diabetic and nondiabetic models |
| url | http://dx.doi.org/10.1155/2017/7121827 |
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