Alterations of interhemispheric functional connectivity in patients with hypertensive retinopathy using voxel-mirrored homotopic connectivity: a resting state fMRI study
AIM: To analyze whether alterations of voxel mirror homology connectivity (VMHC) values, as determined by resting-state functional magnetic resonance imaging (rs-fMRI), occur in cerebral regions of patients with hypertensive retinopathy (HR) and to determine the relationship between VMHC values and...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2025-02-01
|
| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/en_publish/2025/2/20250214.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841526972541304832 |
|---|---|
| author | Xue-Lin Wang Yu Chen Jin-Yu Hu Hong Wei Qian Ling Liang-Qi He Cheng Chen Yi-Xin Wang Yan-Mei Zeng Xiao-Yu Wang Qian-Min Ge Xu Chen Yi Shao |
| author_facet | Xue-Lin Wang Yu Chen Jin-Yu Hu Hong Wei Qian Ling Liang-Qi He Cheng Chen Yi-Xin Wang Yan-Mei Zeng Xiao-Yu Wang Qian-Min Ge Xu Chen Yi Shao |
| author_sort | Xue-Lin Wang |
| collection | DOAJ |
| description | AIM: To analyze whether alterations of voxel mirror homology connectivity (VMHC) values, as determined by resting-state functional magnetic resonance imaging (rs-fMRI), occur in cerebral regions of patients with hypertensive retinopathy (HR) and to determine the relationship between VMHC values and clinical characteristics in patients with HR. METHODS: Twenty-one patients with HR and 21 age-matched healthy controls (HCs) were assessed by rs-fMRI scanning. The functional connectivity between the hemispheres of the cerebrum was assessed by measuring VMHC, with the ability of VMHC to distinguish between the HR and HC groups assessed using receiver operating characteristic (ROC) curve analysis. Differences in the demographic and clinical characteristics of the HR and HC groups were analyzed by independent sample t-tests. The relationship between average VMHC in several brain areas of HR patients and clinical features was determined using Pearson correlation analysis. RESULTS: Mean VMHC values of the bilateral cuneus gyrus (BA19), bilateral middle orbitofrontal gyrus (BA47), bilateral middle temporal gyrus (BA39) and bilateral superior medial frontal gyrus (BA9) were lower in the HR than in the HC group. CONCLUSION: VMHC values can predict the development of early HR, prevent the transformation of hypertensive microangiopathy, and provide useful information explaining the changes in neural mechanism associated with HR. |
| format | Article |
| id | doaj-art-a66830a8b79a4f2facfc4ef8623b6f2b |
| institution | Kabale University |
| issn | 2222-3959 2227-4898 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj-art-a66830a8b79a4f2facfc4ef8623b6f2b2025-01-16T07:54:35ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982025-02-0118229730710.18240/ijo.2025.02.1420250214Alterations of interhemispheric functional connectivity in patients with hypertensive retinopathy using voxel-mirrored homotopic connectivity: a resting state fMRI studyXue-Lin Wang0Yu Chen1Jin-Yu Hu2Hong Wei3Qian Ling4Liang-Qi He5Cheng Chen6Yi-Xin Wang7Yan-Mei Zeng8Xiao-Yu Wang9Qian-Min Ge10Xu Chen11Yi Shao12Yi Shao. Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai 200080, China. freebee99@163.com; Yi-Xin Wang. School of Optometry and Vision Science, Cardiff University, Cardiff, CF24 4HQ, Wales, UK. 731579475@qq.comDepartment of Traditional Chinese Medicine, the Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110000, Liaoning Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaSchool of Optometry and Vision Science, Cardiff University, Cardiff, CF24 4HQ, Wales, UKDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaOphthalmology Centre of Maastricht University, Maastricht 6200MS, Limburg Provincie, the NetherlandsDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai 200080, ChinaAIM: To analyze whether alterations of voxel mirror homology connectivity (VMHC) values, as determined by resting-state functional magnetic resonance imaging (rs-fMRI), occur in cerebral regions of patients with hypertensive retinopathy (HR) and to determine the relationship between VMHC values and clinical characteristics in patients with HR. METHODS: Twenty-one patients with HR and 21 age-matched healthy controls (HCs) were assessed by rs-fMRI scanning. The functional connectivity between the hemispheres of the cerebrum was assessed by measuring VMHC, with the ability of VMHC to distinguish between the HR and HC groups assessed using receiver operating characteristic (ROC) curve analysis. Differences in the demographic and clinical characteristics of the HR and HC groups were analyzed by independent sample t-tests. The relationship between average VMHC in several brain areas of HR patients and clinical features was determined using Pearson correlation analysis. RESULTS: Mean VMHC values of the bilateral cuneus gyrus (BA19), bilateral middle orbitofrontal gyrus (BA47), bilateral middle temporal gyrus (BA39) and bilateral superior medial frontal gyrus (BA9) were lower in the HR than in the HC group. CONCLUSION: VMHC values can predict the development of early HR, prevent the transformation of hypertensive microangiopathy, and provide useful information explaining the changes in neural mechanism associated with HR.http://ies.ijo.cn/en_publish/2025/2/20250214.pdfhypertensive retinopathyvoxel-mirrored homotopic connectivityneuroimagingfunctional mriresting state |
| spellingShingle | Xue-Lin Wang Yu Chen Jin-Yu Hu Hong Wei Qian Ling Liang-Qi He Cheng Chen Yi-Xin Wang Yan-Mei Zeng Xiao-Yu Wang Qian-Min Ge Xu Chen Yi Shao Alterations of interhemispheric functional connectivity in patients with hypertensive retinopathy using voxel-mirrored homotopic connectivity: a resting state fMRI study International Journal of Ophthalmology hypertensive retinopathy voxel-mirrored homotopic connectivity neuroimaging functional mri resting state |
| title | Alterations of interhemispheric functional connectivity in patients with hypertensive retinopathy using voxel-mirrored homotopic connectivity: a resting state fMRI study |
| title_full | Alterations of interhemispheric functional connectivity in patients with hypertensive retinopathy using voxel-mirrored homotopic connectivity: a resting state fMRI study |
| title_fullStr | Alterations of interhemispheric functional connectivity in patients with hypertensive retinopathy using voxel-mirrored homotopic connectivity: a resting state fMRI study |
| title_full_unstemmed | Alterations of interhemispheric functional connectivity in patients with hypertensive retinopathy using voxel-mirrored homotopic connectivity: a resting state fMRI study |
| title_short | Alterations of interhemispheric functional connectivity in patients with hypertensive retinopathy using voxel-mirrored homotopic connectivity: a resting state fMRI study |
| title_sort | alterations of interhemispheric functional connectivity in patients with hypertensive retinopathy using voxel mirrored homotopic connectivity a resting state fmri study |
| topic | hypertensive retinopathy voxel-mirrored homotopic connectivity neuroimaging functional mri resting state |
| url | http://ies.ijo.cn/en_publish/2025/2/20250214.pdf |
| work_keys_str_mv | AT xuelinwang alterationsofinterhemisphericfunctionalconnectivityinpatientswithhypertensiveretinopathyusingvoxelmirroredhomotopicconnectivityarestingstatefmristudy AT yuchen alterationsofinterhemisphericfunctionalconnectivityinpatientswithhypertensiveretinopathyusingvoxelmirroredhomotopicconnectivityarestingstatefmristudy AT jinyuhu alterationsofinterhemisphericfunctionalconnectivityinpatientswithhypertensiveretinopathyusingvoxelmirroredhomotopicconnectivityarestingstatefmristudy AT hongwei alterationsofinterhemisphericfunctionalconnectivityinpatientswithhypertensiveretinopathyusingvoxelmirroredhomotopicconnectivityarestingstatefmristudy AT qianling alterationsofinterhemisphericfunctionalconnectivityinpatientswithhypertensiveretinopathyusingvoxelmirroredhomotopicconnectivityarestingstatefmristudy AT liangqihe alterationsofinterhemisphericfunctionalconnectivityinpatientswithhypertensiveretinopathyusingvoxelmirroredhomotopicconnectivityarestingstatefmristudy AT chengchen alterationsofinterhemisphericfunctionalconnectivityinpatientswithhypertensiveretinopathyusingvoxelmirroredhomotopicconnectivityarestingstatefmristudy AT yixinwang alterationsofinterhemisphericfunctionalconnectivityinpatientswithhypertensiveretinopathyusingvoxelmirroredhomotopicconnectivityarestingstatefmristudy AT yanmeizeng alterationsofinterhemisphericfunctionalconnectivityinpatientswithhypertensiveretinopathyusingvoxelmirroredhomotopicconnectivityarestingstatefmristudy AT xiaoyuwang alterationsofinterhemisphericfunctionalconnectivityinpatientswithhypertensiveretinopathyusingvoxelmirroredhomotopicconnectivityarestingstatefmristudy AT qianminge alterationsofinterhemisphericfunctionalconnectivityinpatientswithhypertensiveretinopathyusingvoxelmirroredhomotopicconnectivityarestingstatefmristudy AT xuchen alterationsofinterhemisphericfunctionalconnectivityinpatientswithhypertensiveretinopathyusingvoxelmirroredhomotopicconnectivityarestingstatefmristudy AT yishao alterationsofinterhemisphericfunctionalconnectivityinpatientswithhypertensiveretinopathyusingvoxelmirroredhomotopicconnectivityarestingstatefmristudy |