Photodynamic Therapy for Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis
To assess the efficacy of photodynamic therapy (PDT) for oral squamous cell carcinoma (OSCC), literature on this topic from Embase, PubMed, and Web of Science were obtained and analyzed. The response and recurrence rates with 95% confidence intervals (CI) were calculated using the DerSimonia–Laird m...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | International Journal of Photoenergy |
| Online Access: | http://dx.doi.org/10.1155/2021/6641358 |
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| author | Jiao Lin Guangcheng Ni Tingting Ding Shangxue Lei Liang Zhong Na Liu Keran Pan Ting Chen Xin Zeng Hao Xu Taiwen Li Hongxia Dan |
| author_facet | Jiao Lin Guangcheng Ni Tingting Ding Shangxue Lei Liang Zhong Na Liu Keran Pan Ting Chen Xin Zeng Hao Xu Taiwen Li Hongxia Dan |
| author_sort | Jiao Lin |
| collection | DOAJ |
| description | To assess the efficacy of photodynamic therapy (PDT) for oral squamous cell carcinoma (OSCC), literature on this topic from Embase, PubMed, and Web of Science were obtained and analyzed. The response and recurrence rates with 95% confidence intervals (CI) were calculated using the DerSimonia–Laird method. The pooled complete response (CR) rate from the included studies was 0.799 (95% CI: 0.708–0.867), while the overall response (OR) rate was 0.967 (95% CI: 0.902–0.989). The recurrence rate (RR) was 0.158 (95% CI: 0.090–0.264). A subgroup analysis of lesion site, photosensitizer, laser type, radiant exposure, and power density revealed no statistically significant differences. In general, PDT is effective for the treatment of early OSCC. Investigations on the influence of PDT on the survival of OSCC patients, optimization of the treatment regimen, and evaluation of response after treatment are still needed. |
| format | Article |
| id | doaj-art-a643bbe1485142d1b03c8b6ddc2fa457 |
| institution | Kabale University |
| issn | 1110-662X 1687-529X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Photoenergy |
| spelling | doaj-art-a643bbe1485142d1b03c8b6ddc2fa4572025-02-03T05:52:58ZengWileyInternational Journal of Photoenergy1110-662X1687-529X2021-01-01202110.1155/2021/66413586641358Photodynamic Therapy for Oral Squamous Cell Carcinoma: A Systematic Review and Meta-AnalysisJiao Lin0Guangcheng Ni1Tingting Ding2Shangxue Lei3Liang Zhong4Na Liu5Keran Pan6Ting Chen7Xin Zeng8Hao Xu9Taiwen Li10Hongxia Dan11State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaTo assess the efficacy of photodynamic therapy (PDT) for oral squamous cell carcinoma (OSCC), literature on this topic from Embase, PubMed, and Web of Science were obtained and analyzed. The response and recurrence rates with 95% confidence intervals (CI) were calculated using the DerSimonia–Laird method. The pooled complete response (CR) rate from the included studies was 0.799 (95% CI: 0.708–0.867), while the overall response (OR) rate was 0.967 (95% CI: 0.902–0.989). The recurrence rate (RR) was 0.158 (95% CI: 0.090–0.264). A subgroup analysis of lesion site, photosensitizer, laser type, radiant exposure, and power density revealed no statistically significant differences. In general, PDT is effective for the treatment of early OSCC. Investigations on the influence of PDT on the survival of OSCC patients, optimization of the treatment regimen, and evaluation of response after treatment are still needed.http://dx.doi.org/10.1155/2021/6641358 |
| spellingShingle | Jiao Lin Guangcheng Ni Tingting Ding Shangxue Lei Liang Zhong Na Liu Keran Pan Ting Chen Xin Zeng Hao Xu Taiwen Li Hongxia Dan Photodynamic Therapy for Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis International Journal of Photoenergy |
| title | Photodynamic Therapy for Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis |
| title_full | Photodynamic Therapy for Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis |
| title_fullStr | Photodynamic Therapy for Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Photodynamic Therapy for Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis |
| title_short | Photodynamic Therapy for Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis |
| title_sort | photodynamic therapy for oral squamous cell carcinoma a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2021/6641358 |
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