Participant experiences in a combination HIV cure-related trial with extended analytical treatment interruption in San Francisco, United States
Background There is limited systematic information available about the perspectives of participants enrolled in intensive combination HIV cure-related trials inclusive of an extended analytical treatment interruption (ATI). Objective To assess and understand experiences of people with HIV involved i...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-01-01
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| Series: | HIV Research & Clinical Practice |
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| Online Access: | http://dx.doi.org/10.1080/25787489.2024.2312318 |
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| author | Karine Dubé Samuel O. Ndukwe Ana Korolkova Lynda Dee Jeremy Sugarman John A. Sauceda |
| author_facet | Karine Dubé Samuel O. Ndukwe Ana Korolkova Lynda Dee Jeremy Sugarman John A. Sauceda |
| author_sort | Karine Dubé |
| collection | DOAJ |
| description | Background There is limited systematic information available about the perspectives of participants enrolled in intensive combination HIV cure-related trials inclusive of an extended analytical treatment interruption (ATI). Objective To assess and understand experiences of people with HIV involved in a combination HIV cure-related trial with an extended ATI. Methods The trial included five interventions and was followed by an ATI lasting up to 52 wk. From 2022 – 2023, we conducted in-depth interviews with study participants following their extended ATIs. Interviews were audio-recorded, transcribed, and analyzed via conventional thematic analysis. Results We interviewed seven participants. The majority were male, White, and non-Hispanic, with a median age of 37 years. Trust in the research team, scientific altruism and hope of becoming a post-intervention controller were key motivators for joining the trial. Interviewees reported being satisfied with their decision to participate in the trial and the extended ATI. Most recounted feelings of worry related to viral rebound during the ATI. Participants reported both defeat and relief with ART restart. Four faced challenges with protecting partners from HIV during their ATI, such as trying to find out if their partner(s) were using pre-exposure prophylaxis. Conclusions Our findings demonstrate potential improvements for future ATI trial participant experiences, such as more robust resources for psychosocial support and partner protections. Dedicating greater effort to understanding participant ATI experiences can inform the design of future participant-centered HIV cure trial protocols. |
| format | Article |
| id | doaj-art-a6422f2af70e4932834bd92cd9335ea5 |
| institution | Kabale University |
| issn | 2578-7470 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | HIV Research & Clinical Practice |
| spelling | doaj-art-a6422f2af70e4932834bd92cd9335ea52025-01-02T11:44:28ZengTaylor & Francis GroupHIV Research & Clinical Practice2578-74702024-01-0125110.1080/25787489.2024.23123182312318Participant experiences in a combination HIV cure-related trial with extended analytical treatment interruption in San Francisco, United StatesKarine Dubé0Samuel O. Ndukwe1Ana Korolkova2Lynda Dee3Jeremy Sugarman4John A. Sauceda5Division of Infectious Diseases and Global Public Health (IDGPH), Department of Medicine, University of California San Diego (UCSD)Division of Infectious Diseases and Global Public Health (IDGPH), Department of Medicine, University of California San Diego (UCSD)Division of Infectious Diseases and Global Public Health (IDGPH), Department of Medicine, University of California San Diego (UCSD)AIDS Action BaltimoreJohns Hopkins Berman Institute for BioethicsDivision of Prevention Science, Center for AIDS Prevention Studies (CAPS)Background There is limited systematic information available about the perspectives of participants enrolled in intensive combination HIV cure-related trials inclusive of an extended analytical treatment interruption (ATI). Objective To assess and understand experiences of people with HIV involved in a combination HIV cure-related trial with an extended ATI. Methods The trial included five interventions and was followed by an ATI lasting up to 52 wk. From 2022 – 2023, we conducted in-depth interviews with study participants following their extended ATIs. Interviews were audio-recorded, transcribed, and analyzed via conventional thematic analysis. Results We interviewed seven participants. The majority were male, White, and non-Hispanic, with a median age of 37 years. Trust in the research team, scientific altruism and hope of becoming a post-intervention controller were key motivators for joining the trial. Interviewees reported being satisfied with their decision to participate in the trial and the extended ATI. Most recounted feelings of worry related to viral rebound during the ATI. Participants reported both defeat and relief with ART restart. Four faced challenges with protecting partners from HIV during their ATI, such as trying to find out if their partner(s) were using pre-exposure prophylaxis. Conclusions Our findings demonstrate potential improvements for future ATI trial participant experiences, such as more robust resources for psychosocial support and partner protections. Dedicating greater effort to understanding participant ATI experiences can inform the design of future participant-centered HIV cure trial protocols.http://dx.doi.org/10.1080/25787489.2024.2312318hiv cure researchanalytical treatment interruptionsparticipant experiencessocio-behavioral researchcombination trialspeople with hiv |
| spellingShingle | Karine Dubé Samuel O. Ndukwe Ana Korolkova Lynda Dee Jeremy Sugarman John A. Sauceda Participant experiences in a combination HIV cure-related trial with extended analytical treatment interruption in San Francisco, United States HIV Research & Clinical Practice hiv cure research analytical treatment interruptions participant experiences socio-behavioral research combination trials people with hiv |
| title | Participant experiences in a combination HIV cure-related trial with extended analytical treatment interruption in San Francisco, United States |
| title_full | Participant experiences in a combination HIV cure-related trial with extended analytical treatment interruption in San Francisco, United States |
| title_fullStr | Participant experiences in a combination HIV cure-related trial with extended analytical treatment interruption in San Francisco, United States |
| title_full_unstemmed | Participant experiences in a combination HIV cure-related trial with extended analytical treatment interruption in San Francisco, United States |
| title_short | Participant experiences in a combination HIV cure-related trial with extended analytical treatment interruption in San Francisco, United States |
| title_sort | participant experiences in a combination hiv cure related trial with extended analytical treatment interruption in san francisco united states |
| topic | hiv cure research analytical treatment interruptions participant experiences socio-behavioral research combination trials people with hiv |
| url | http://dx.doi.org/10.1080/25787489.2024.2312318 |
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