NF45/NF90‐mediated rDNA transcription provides a novel target for immunosuppressant development

NF45/NF90‐mediated rDNA transcription provides a novel target for immunosuppressant development

Abstract Herein, we demonstrate that NFAT, a key regulator of the immune response, translocates from cytoplasm to nucleolus and interacts with NF45/NF90 complex to collaboratively promote rDNA transcription via triggering the directly binding of NF45/NF90 to the ARRE2‐like sequences in rDNA promoter...

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Bibliographic Details
Main Authors: Hsiang‐i Tsai, Xiaobin Zeng, Longshan Liu, Shengchang Xin, Yingyi Wu, Zhanxue Xu, Huanxi Zhang, Gan Liu, Zirong Bi, Dandan Su, Min Yang, Yijing Tao, Changxi Wang, Jing Zhao, John E Eriksson, Wenbin Deng, Fang Cheng, Hongbo Chen
Format: Article
Language:English
Published: Springer Nature 2021-02-01
Series:EMBO Molecular Medicine
Subjects:
CX5461
NF45/NF90
NFAT
nucleolus
organ transplantation
Online Access:https://doi.org/10.15252/emmm.202012834
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https://doi.org/10.15252/emmm.202012834

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