Passive versus active intra-abdominal drainage following pancreatic resection: does a superior drainage system exist? A protocol for systematic review
Background Clinically relevant postoperative pancreatic fistula (CR-POPF) is the most common cause of major morbidity following pancreatic resection. Intra-abdominal drains are frequently positioned adjacent to the pancreatic anastomosis or transection margin at the time of surgery to aid in detecti...
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| Format: | Article |
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BMJ Publishing Group
2019-09-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/9/9/e031319.full |
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| author | Heather Smith Laura Baker Lily Park Guillaume Martel Jad Abou Khalil Fady Balaa Kimberly A Bertens |
| author_facet | Heather Smith Laura Baker Lily Park Guillaume Martel Jad Abou Khalil Fady Balaa Kimberly A Bertens |
| author_sort | Heather Smith |
| collection | DOAJ |
| description | Background Clinically relevant postoperative pancreatic fistula (CR-POPF) is the most common cause of major morbidity following pancreatic resection. Intra-abdominal drains are frequently positioned adjacent to the pancreatic anastomosis or transection margin at the time of surgery to aid in detection and management of CR-POPF. Drains can either evacuate fluid by passive gravity (PG) or be attached to a closed suction (CS) system using negative pressure. There is controversy as to whether one of these two systems is superior. The objective of this review is to identify and compare the incidence of adverse events (AEs) and resource utilisation associated with PG and CS drainage following pancreatic resections.Methods and analysis MEDLINE, EMBASE, CINAHL and Cochrane Central Registry of Controlled Trials will be searched from inception to April 2019, to identify interventional and observational studies comparing PG and CS drains following pancreatic resection. The primary outcome is POPF as defined by the International Study Group for Pancreatic Fistula in 2017. Secondary outcomes include postoperative AE, resource utilisation (length of stay, return to emergency department, readmission and reintervention), time to drain removal and quality of life. Study selection, data extraction and risk of bias assessment will be performed independently, by two reviewers. A meta-analysis will be conducted if deemed statistically appropriate. Subgroup analysis by study design will be performed. Study heterogeneity will be calculated with the χ2 test and reported as I2 statistics. Statistical analyses will be conducted and displayed using RevMan V.5.3Ethics and dissemination Ethics approval is not required. The results of this study will be submitted to relevant conferences for presentation and peer-reviewed journals for publication.PROSPERO registration number CRD42019123647. |
| format | Article |
| id | doaj-art-a63bee1c1c4c46fa8d8f3eb2ed0fc5d6 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-a63bee1c1c4c46fa8d8f3eb2ed0fc5d62024-11-28T07:20:08ZengBMJ Publishing GroupBMJ Open2044-60552019-09-019910.1136/bmjopen-2019-031319Passive versus active intra-abdominal drainage following pancreatic resection: does a superior drainage system exist? A protocol for systematic reviewHeather Smith0Laura Baker1Lily Park2Guillaume Martel3Jad Abou Khalil4Fady Balaa5Kimberly A Bertens6Barwon Health, Geelong, VIC, AustraliaGeneral Surgery, The Ottawa Hospital, Ottawa, Ontario, CanadaSchool of Medicine, University of Ottawa, Ottawa, Ontario, CanadaDépartement de médecine familiale et de médecine durgence, Université Laval Faculté de médecine, Quebec, Québec, CanadaHepatopancreaticobiliary Surgery, Department of Surgery, The Ottawa Hospital, Ottawa, Ontario, CanadaSurgery, The Ottawa Hospital, Ottawa, Ontario, CanadaSurgery, The Ottawa Hospital, Ottawa, Ontario, CanadaBackground Clinically relevant postoperative pancreatic fistula (CR-POPF) is the most common cause of major morbidity following pancreatic resection. Intra-abdominal drains are frequently positioned adjacent to the pancreatic anastomosis or transection margin at the time of surgery to aid in detection and management of CR-POPF. Drains can either evacuate fluid by passive gravity (PG) or be attached to a closed suction (CS) system using negative pressure. There is controversy as to whether one of these two systems is superior. The objective of this review is to identify and compare the incidence of adverse events (AEs) and resource utilisation associated with PG and CS drainage following pancreatic resections.Methods and analysis MEDLINE, EMBASE, CINAHL and Cochrane Central Registry of Controlled Trials will be searched from inception to April 2019, to identify interventional and observational studies comparing PG and CS drains following pancreatic resection. The primary outcome is POPF as defined by the International Study Group for Pancreatic Fistula in 2017. Secondary outcomes include postoperative AE, resource utilisation (length of stay, return to emergency department, readmission and reintervention), time to drain removal and quality of life. Study selection, data extraction and risk of bias assessment will be performed independently, by two reviewers. A meta-analysis will be conducted if deemed statistically appropriate. Subgroup analysis by study design will be performed. Study heterogeneity will be calculated with the χ2 test and reported as I2 statistics. Statistical analyses will be conducted and displayed using RevMan V.5.3Ethics and dissemination Ethics approval is not required. The results of this study will be submitted to relevant conferences for presentation and peer-reviewed journals for publication.PROSPERO registration number CRD42019123647.https://bmjopen.bmj.com/content/9/9/e031319.full |
| spellingShingle | Heather Smith Laura Baker Lily Park Guillaume Martel Jad Abou Khalil Fady Balaa Kimberly A Bertens Passive versus active intra-abdominal drainage following pancreatic resection: does a superior drainage system exist? A protocol for systematic review BMJ Open |
| title | Passive versus active intra-abdominal drainage following pancreatic resection: does a superior drainage system exist? A protocol for systematic review |
| title_full | Passive versus active intra-abdominal drainage following pancreatic resection: does a superior drainage system exist? A protocol for systematic review |
| title_fullStr | Passive versus active intra-abdominal drainage following pancreatic resection: does a superior drainage system exist? A protocol for systematic review |
| title_full_unstemmed | Passive versus active intra-abdominal drainage following pancreatic resection: does a superior drainage system exist? A protocol for systematic review |
| title_short | Passive versus active intra-abdominal drainage following pancreatic resection: does a superior drainage system exist? A protocol for systematic review |
| title_sort | passive versus active intra abdominal drainage following pancreatic resection does a superior drainage system exist a protocol for systematic review |
| url | https://bmjopen.bmj.com/content/9/9/e031319.full |
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