Phytochemical Study of the Plant <i>Centaurea bruguieriana</i> (DC.) Hand.-Mazz. subsp. <i>belangeriana</i> (DC.) Bornm. of the Family Asteraceae
The aim of this study is to isolate and identify the secondary metabolites of the aerial part of the plant <i>Centaurea bruguieriana</i> (DC.) Hand. -Mazz. subsp. <i>belangeriana</i> (DC.) Bornm. (<i>Centaurea phyllocephala</i>) (Asteraceae), and to study the biol...
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2024-11-01
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| author | Kyriakos Michail Dimitriadis Olga Tsiftsoglou Dimitra Hadjipavlou-Litina Mohammad Arfan Diamanto Lazari |
| author_facet | Kyriakos Michail Dimitriadis Olga Tsiftsoglou Dimitra Hadjipavlou-Litina Mohammad Arfan Diamanto Lazari |
| author_sort | Kyriakos Michail Dimitriadis |
| collection | DOAJ |
| description | The aim of this study is to isolate and identify the secondary metabolites of the aerial part of the plant <i>Centaurea bruguieriana</i> (DC.) Hand. -Mazz. subsp. <i>belangeriana</i> (DC.) Bornm. (<i>Centaurea phyllocephala</i>) (Asteraceae), and to study the biological activities of the extracts and isolated compounds with in vitro tests. With the use of chromatography and spectroscopy we identified three elemanolides: 8α-O-(3,4-dihydroxy-2-methylenebutanoyloxy) dehydromelitensine (<b>1</b>), 8α-O-(3-hydroxy-4-acetoxy-2-methylene-butanoyloxy) dehydromelitensine (<b>2</b>) and methyl 6α,8α,15-trihydroxyelema-1,3,11(13)-trien-12-oate (<b>3</b>); two germacranolides: cnicin (<b>4</b>) and 4′-O-acetylcnicin (<b>5</b>); one eudesmanolide: malacitanolide (<b>6</b>); five flavonoids: cirsilineol (<b>7</b>), eupatorine (<b>8</b>), 5-hydroxy, 6,7,3′,4′-tetramethoxy-flavone (<b>9</b>), 3,4′,5,7-tetrahydroxy-6-methoxyflavone 3-O-β-D-glucopyranoside (<b>10</b>) and astragalin (<b>11</b>); and also p-OH-benzoic acid (<b>12</b>) and 3-hydroxy-2-methyl-butyrolactone (<b>13</b>). All the isolated compounds were evaluated in silico with the use of molinspiration, while the crude extract, the organic phase B and compounds <b>2</b>, <b>4</b>, <b>5</b> and <b>6</b> were tested as antioxidants and anti-inflammatories for the inhibition of lipid hyperoxide and the inhibition of lipoxygenase. |
| format | Article |
| id | doaj-art-a6119714046b4b0d95d71310c4ef7526 |
| institution | Kabale University |
| issn | 2297-8739 |
| language | English |
| publishDate | 2024-11-01 |
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| spelling | doaj-art-a6119714046b4b0d95d71310c4ef75262024-11-26T18:21:58ZengMDPI AGSeparations2297-87392024-11-01111131910.3390/separations11110319Phytochemical Study of the Plant <i>Centaurea bruguieriana</i> (DC.) Hand.-Mazz. subsp. <i>belangeriana</i> (DC.) Bornm. of the Family AsteraceaeKyriakos Michail Dimitriadis0Olga Tsiftsoglou1Dimitra Hadjipavlou-Litina2Mohammad Arfan3Diamanto Lazari4Laboratory of Pharmacognosy, Faculty of Health Sciences, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceLaboratory of Pharmacognosy, Faculty of Health Sciences, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceLaboratory of Pharmaceutical Chemistry, Faculty of Health Sciences, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceInternational Center for Chemical & Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi 75210, PakistanLaboratory of Pharmacognosy, Faculty of Health Sciences, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceThe aim of this study is to isolate and identify the secondary metabolites of the aerial part of the plant <i>Centaurea bruguieriana</i> (DC.) Hand. -Mazz. subsp. <i>belangeriana</i> (DC.) Bornm. (<i>Centaurea phyllocephala</i>) (Asteraceae), and to study the biological activities of the extracts and isolated compounds with in vitro tests. With the use of chromatography and spectroscopy we identified three elemanolides: 8α-O-(3,4-dihydroxy-2-methylenebutanoyloxy) dehydromelitensine (<b>1</b>), 8α-O-(3-hydroxy-4-acetoxy-2-methylene-butanoyloxy) dehydromelitensine (<b>2</b>) and methyl 6α,8α,15-trihydroxyelema-1,3,11(13)-trien-12-oate (<b>3</b>); two germacranolides: cnicin (<b>4</b>) and 4′-O-acetylcnicin (<b>5</b>); one eudesmanolide: malacitanolide (<b>6</b>); five flavonoids: cirsilineol (<b>7</b>), eupatorine (<b>8</b>), 5-hydroxy, 6,7,3′,4′-tetramethoxy-flavone (<b>9</b>), 3,4′,5,7-tetrahydroxy-6-methoxyflavone 3-O-β-D-glucopyranoside (<b>10</b>) and astragalin (<b>11</b>); and also p-OH-benzoic acid (<b>12</b>) and 3-hydroxy-2-methyl-butyrolactone (<b>13</b>). All the isolated compounds were evaluated in silico with the use of molinspiration, while the crude extract, the organic phase B and compounds <b>2</b>, <b>4</b>, <b>5</b> and <b>6</b> were tested as antioxidants and anti-inflammatories for the inhibition of lipid hyperoxide and the inhibition of lipoxygenase.https://www.mdpi.com/2297-8739/11/11/319sesquiterpene lactonesflavonoidsantioxidantanti-inflammatorymolispiration |
| spellingShingle | Kyriakos Michail Dimitriadis Olga Tsiftsoglou Dimitra Hadjipavlou-Litina Mohammad Arfan Diamanto Lazari Phytochemical Study of the Plant <i>Centaurea bruguieriana</i> (DC.) Hand.-Mazz. subsp. <i>belangeriana</i> (DC.) Bornm. of the Family Asteraceae Separations sesquiterpene lactones flavonoids antioxidant anti-inflammatory molispiration |
| title | Phytochemical Study of the Plant <i>Centaurea bruguieriana</i> (DC.) Hand.-Mazz. subsp. <i>belangeriana</i> (DC.) Bornm. of the Family Asteraceae |
| title_full | Phytochemical Study of the Plant <i>Centaurea bruguieriana</i> (DC.) Hand.-Mazz. subsp. <i>belangeriana</i> (DC.) Bornm. of the Family Asteraceae |
| title_fullStr | Phytochemical Study of the Plant <i>Centaurea bruguieriana</i> (DC.) Hand.-Mazz. subsp. <i>belangeriana</i> (DC.) Bornm. of the Family Asteraceae |
| title_full_unstemmed | Phytochemical Study of the Plant <i>Centaurea bruguieriana</i> (DC.) Hand.-Mazz. subsp. <i>belangeriana</i> (DC.) Bornm. of the Family Asteraceae |
| title_short | Phytochemical Study of the Plant <i>Centaurea bruguieriana</i> (DC.) Hand.-Mazz. subsp. <i>belangeriana</i> (DC.) Bornm. of the Family Asteraceae |
| title_sort | phytochemical study of the plant i centaurea bruguieriana i dc hand mazz subsp i belangeriana i dc bornm of the family asteraceae |
| topic | sesquiterpene lactones flavonoids antioxidant anti-inflammatory molispiration |
| url | https://www.mdpi.com/2297-8739/11/11/319 |
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