Phytochemical Study of the Plant <i>Centaurea bruguieriana</i> (DC.) Hand.-Mazz. subsp. <i>belangeriana</i> (DC.) Bornm. of the Family Asteraceae

Phytochemical Study of the Plant <i>Centaurea bruguieriana</i> (DC.) Hand.-Mazz. subsp. <i>belangeriana</i> (DC.) Bornm. of the Family Asteraceae

The aim of this study is to isolate and identify the secondary metabolites of the aerial part of the plant <i>Centaurea bruguieriana</i> (DC.) Hand. -Mazz. subsp. <i>belangeriana</i> (DC.) Bornm. (<i>Centaurea phyllocephala</i>) (Asteraceae), and to study the biol...

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Bibliographic Details
Main Authors: Kyriakos Michail Dimitriadis, Olga Tsiftsoglou, Dimitra Hadjipavlou-Litina, Mohammad Arfan, Diamanto Lazari
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Separations
Subjects:
sesquiterpene lactones
flavonoids
antioxidant
anti-inflammatory
molispiration
Online Access:https://www.mdpi.com/2297-8739/11/11/319
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Summary:The aim of this study is to isolate and identify the secondary metabolites of the aerial part of the plant <i>Centaurea bruguieriana</i> (DC.) Hand. -Mazz. subsp. <i>belangeriana</i> (DC.) Bornm. (<i>Centaurea phyllocephala</i>) (Asteraceae), and to study the biological activities of the extracts and isolated compounds with in vitro tests. With the use of chromatography and spectroscopy we identified three elemanolides: 8α-O-(3,4-dihydroxy-2-methylenebutanoyloxy) dehydromelitensine (<b>1</b>), 8α-O-(3-hydroxy-4-acetoxy-2-methylene-butanoyloxy) dehydromelitensine (<b>2</b>) and methyl 6α,8α,15-trihydroxyelema-1,3,11(13)-trien-12-oate (<b>3</b>); two germacranolides: cnicin (<b>4</b>) and 4′-O-acetylcnicin (<b>5</b>); one eudesmanolide: malacitanolide (<b>6</b>); five flavonoids: cirsilineol (<b>7</b>), eupatorine (<b>8</b>), 5-hydroxy, 6,7,3′,4′-tetramethoxy-flavone (<b>9</b>), 3,4′,5,7-tetrahydroxy-6-methoxyflavone 3-O-β-D-glucopyranoside (<b>10</b>) and astragalin (<b>11</b>); and also p-OH-benzoic acid (<b>12</b>) and 3-hydroxy-2-methyl-butyrolactone (<b>13</b>). All the isolated compounds were evaluated in silico with the use of molinspiration, while the crude extract, the organic phase B and compounds <b>2</b>, <b>4</b>, <b>5</b> and <b>6</b> were tested as antioxidants and anti-inflammatories for the inhibition of lipid hyperoxide and the inhibition of lipoxygenase.
ISSN:2297-8739

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