Quasispecies theory and emerging viruses: challenges and applications
Abstract Quasispecies theory revolutionized our understanding of viral evolution by describing viruses as dynamic populations of genetically diverse variants constantly adapting. This article explores the theory’s role in virus-host interactions, including immune evasion, drug resistance, and viral...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-11-01
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| Series: | npj Viruses |
| Online Access: | https://doi.org/10.1038/s44298-024-00066-w |
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| _version_ | 1846165497259753472 |
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| author | Josep Sardanyés Celia Perales Esteban Domingo Santiago F. Elena |
| author_facet | Josep Sardanyés Celia Perales Esteban Domingo Santiago F. Elena |
| author_sort | Josep Sardanyés |
| collection | DOAJ |
| description | Abstract Quasispecies theory revolutionized our understanding of viral evolution by describing viruses as dynamic populations of genetically diverse variants constantly adapting. This article explores the theory’s role in virus-host interactions, including immune evasion, drug resistance, and viral emergence. We review the original model, recent advances, and key virus dynamics needing incorporation into quasispecies theory. We introduce the ultracube concept as a more realistic multidimensional sequence space to investigate virus evolutionary dynamics. |
| format | Article |
| id | doaj-art-a607f47feb404195b5851e28d9dea766 |
| institution | Kabale University |
| issn | 2948-1767 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Viruses |
| spelling | doaj-art-a607f47feb404195b5851e28d9dea7662024-11-17T12:13:53ZengNature Portfolionpj Viruses2948-17672024-11-012111110.1038/s44298-024-00066-wQuasispecies theory and emerging viruses: challenges and applicationsJosep Sardanyés0Celia Perales1Esteban Domingo2Santiago F. Elena3Centre de Recerca Matemàtica (CRM), Edifici C, Campus de Bellaterra, Cerdanyola del VallèsDepartment of Molecular and Cell Biology, Centro Nacional de Biotecnología, CSIC, CantoblancoMicrobes in Health and Welfare Program, Centro de Biología Molecular “Severo Ochoa”, CSIC-Universidad Autónoma de Madrid, CantoblancoInstitute for Integrative Systems Biology (I2SysBio), CSIC-Universitat de ValènciaAbstract Quasispecies theory revolutionized our understanding of viral evolution by describing viruses as dynamic populations of genetically diverse variants constantly adapting. This article explores the theory’s role in virus-host interactions, including immune evasion, drug resistance, and viral emergence. We review the original model, recent advances, and key virus dynamics needing incorporation into quasispecies theory. We introduce the ultracube concept as a more realistic multidimensional sequence space to investigate virus evolutionary dynamics.https://doi.org/10.1038/s44298-024-00066-w |
| spellingShingle | Josep Sardanyés Celia Perales Esteban Domingo Santiago F. Elena Quasispecies theory and emerging viruses: challenges and applications npj Viruses |
| title | Quasispecies theory and emerging viruses: challenges and applications |
| title_full | Quasispecies theory and emerging viruses: challenges and applications |
| title_fullStr | Quasispecies theory and emerging viruses: challenges and applications |
| title_full_unstemmed | Quasispecies theory and emerging viruses: challenges and applications |
| title_short | Quasispecies theory and emerging viruses: challenges and applications |
| title_sort | quasispecies theory and emerging viruses challenges and applications |
| url | https://doi.org/10.1038/s44298-024-00066-w |
| work_keys_str_mv | AT josepsardanyes quasispeciestheoryandemergingviruseschallengesandapplications AT celiaperales quasispeciestheoryandemergingviruseschallengesandapplications AT estebandomingo quasispeciestheoryandemergingviruseschallengesandapplications AT santiagofelena quasispeciestheoryandemergingviruseschallengesandapplications |