TRPM channels in human cancers: regulatory mechanism and therapeutic prospects
Abstract The transient receptor potential melastatin (TRPM) channel family has been previously implicated in various diseases, including those related to temperature sensing, cardiovascular health, and neurodegeneration. Nowadays, increasing evidence indicates that TRPM family members also play sign...
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BMC
2024-12-01
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| Series: | Biomarker Research |
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| Online Access: | https://doi.org/10.1186/s40364-024-00699-2 |
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| author | Qinfeng Liu Mengyu Hu Shi Li Xin Zhang Rui Zhang Hao Lyu Shuai Xiao Dong Guo Xing-Zhen Chen Jingfeng Tang Cefan Zhou |
| author_facet | Qinfeng Liu Mengyu Hu Shi Li Xin Zhang Rui Zhang Hao Lyu Shuai Xiao Dong Guo Xing-Zhen Chen Jingfeng Tang Cefan Zhou |
| author_sort | Qinfeng Liu |
| collection | DOAJ |
| description | Abstract The transient receptor potential melastatin (TRPM) channel family has been previously implicated in various diseases, including those related to temperature sensing, cardiovascular health, and neurodegeneration. Nowadays, increasing evidence indicates that TRPM family members also play significant roles in various types of cancers, exhibiting both pro- and anti-tumorigenic functions. They are involved in tumor cell proliferation, survival, invasion, and metastasis, serving as potential diagnostic and prognostic biomarkers for cancer. This paper begins by describing the structure and physiological functions of the TRPM family members. It then outlines their roles in several common malignancies, including pancreatic, prostate, colorectal, breast, brain cancer, and melanoma. Subsequently, we focused on investigating the specific mechanisms by which TRPM family members are involved in tumorigenesis and development from both the tumor microenvironment (TME) and intracellular signaling. TRPM channels not only transmit signals from the TME to regulate tumor cell functions, but also mediate extracellular matrix remodeling, which is conducive to the malignant transformation of tumor cells. Importantly, TRPM channels depend on the regulation of the inflow of various ions in cells, and participate in key signaling pathways involved in tumor progression, such as Wnt/β-catenin, MAPK, PI3K/AKT, p53, and autophagy. Finally, we summarize the current strategies and challenges of targeting TRPM channels in tumor treatment, and discuss the feasibility of combining targeted TRPM channel drugs with cancer immunotherapy. |
| format | Article |
| id | doaj-art-a5f8a959fbce4072a3ec3c922f488322 |
| institution | Kabale University |
| issn | 2050-7771 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj-art-a5f8a959fbce4072a3ec3c922f4883222024-12-08T12:38:39ZengBMCBiomarker Research2050-77712024-12-0112112110.1186/s40364-024-00699-2TRPM channels in human cancers: regulatory mechanism and therapeutic prospectsQinfeng Liu0Mengyu Hu1Shi Li2Xin Zhang3Rui Zhang4Hao Lyu5Shuai Xiao6Dong Guo7Xing-Zhen Chen8Jingfeng Tang9Cefan Zhou10National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of TechnologyNational “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of TechnologyNational “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of TechnologyNational “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of TechnologyNational “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of TechnologyNational “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of TechnologyNational “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of TechnologyNational “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of TechnologyMembrane Protein Disease Research Group, Department of Physiology, Faculty of Medicine and Dentistry, University of AlbertaNational “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of TechnologyNational “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of TechnologyAbstract The transient receptor potential melastatin (TRPM) channel family has been previously implicated in various diseases, including those related to temperature sensing, cardiovascular health, and neurodegeneration. Nowadays, increasing evidence indicates that TRPM family members also play significant roles in various types of cancers, exhibiting both pro- and anti-tumorigenic functions. They are involved in tumor cell proliferation, survival, invasion, and metastasis, serving as potential diagnostic and prognostic biomarkers for cancer. This paper begins by describing the structure and physiological functions of the TRPM family members. It then outlines their roles in several common malignancies, including pancreatic, prostate, colorectal, breast, brain cancer, and melanoma. Subsequently, we focused on investigating the specific mechanisms by which TRPM family members are involved in tumorigenesis and development from both the tumor microenvironment (TME) and intracellular signaling. TRPM channels not only transmit signals from the TME to regulate tumor cell functions, but also mediate extracellular matrix remodeling, which is conducive to the malignant transformation of tumor cells. Importantly, TRPM channels depend on the regulation of the inflow of various ions in cells, and participate in key signaling pathways involved in tumor progression, such as Wnt/β-catenin, MAPK, PI3K/AKT, p53, and autophagy. Finally, we summarize the current strategies and challenges of targeting TRPM channels in tumor treatment, and discuss the feasibility of combining targeted TRPM channel drugs with cancer immunotherapy.https://doi.org/10.1186/s40364-024-00699-2TRPM channelsCancer progressionTumor microenvironmentSignaling pathwayAutophagyTargeted tumor therapy |
| spellingShingle | Qinfeng Liu Mengyu Hu Shi Li Xin Zhang Rui Zhang Hao Lyu Shuai Xiao Dong Guo Xing-Zhen Chen Jingfeng Tang Cefan Zhou TRPM channels in human cancers: regulatory mechanism and therapeutic prospects Biomarker Research TRPM channels Cancer progression Tumor microenvironment Signaling pathway Autophagy Targeted tumor therapy |
| title | TRPM channels in human cancers: regulatory mechanism and therapeutic prospects |
| title_full | TRPM channels in human cancers: regulatory mechanism and therapeutic prospects |
| title_fullStr | TRPM channels in human cancers: regulatory mechanism and therapeutic prospects |
| title_full_unstemmed | TRPM channels in human cancers: regulatory mechanism and therapeutic prospects |
| title_short | TRPM channels in human cancers: regulatory mechanism and therapeutic prospects |
| title_sort | trpm channels in human cancers regulatory mechanism and therapeutic prospects |
| topic | TRPM channels Cancer progression Tumor microenvironment Signaling pathway Autophagy Targeted tumor therapy |
| url | https://doi.org/10.1186/s40364-024-00699-2 |
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