Serum total calcium levels as a non-linear predictor of in-hospital mortality in heart failure patients: insights from a retrospective cohort study
Abstract Background Calcium is pivotal in the regulation of bodily homeostasis, with numerous studies highlighting its link to cardiovascular disease in the adult population. However, the relationship between serum calcium levels and the prognosis of heart failure (HF) patients is not clear. This st...
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BMC
2024-11-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-024-04348-2 |
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| author | Jing Song Guojuan Xu Jing Song Guojuan Xu |
| author_facet | Jing Song Guojuan Xu Jing Song Guojuan Xu |
| author_sort | Jing Song |
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| description | Abstract Background Calcium is pivotal in the regulation of bodily homeostasis, with numerous studies highlighting its link to cardiovascular disease in the adult population. However, the relationship between serum calcium levels and the prognosis of heart failure (HF) patients is not clear. This study explored the association between serum total calcium (STC) and in-hospital mortality in patients with HF. Methods Clinical data of 1,176 patients with HF were obtained from the Multiparametric Intelligent Monitoring in Intensive Care III (MIMIC-III) database. The patients were categorized into STC quartiles, and baseline characteristics were comprehensively analyzed. Univariate and multivariate analyses were employed to identify factors associated with in-hospital mortality. To explore the non-linear relationship between STC and mortality, a two-piecewise linear regression model was applied. Subgroup analyses were conducted to identify potential confounding variables. Results In this cohort, 159 (13.53%) patients experienced in-hospital mortality. Significant differences in various parameters were observed among STC quartiles. Univariate analysis identified numerous factors associated with mortality. Multivariate analysis confirmed STC as an independent predictor of in-hospital mortality, with a negative association persisting even after adjusting for confounding factors (odds ratio [OR]: 0.49, 95%CI: 0.32–0.76; P = 0.0016). Non-linear analysis revealed an inflection point at 8.41 mg/dL, below which the risk of in-hospital death significantly increased (OR: 0.26, 95%CI: 0.12–0.55; P = 0.0005). Subgroup analyses indicated a pronounced inverse association in patients without atrial fibrillation or chronic obstructive pulmonary disease, as well as those with a left ventricular ejection fraction ≤ 50%. Conclusion This study identified STC as an independent predictor of in-hospital mortality in HF patients, with a non-linear relationship. |
| format | Article |
| id | doaj-art-a5da21dec351496c8690642c1e185b85 |
| institution | Kabale University |
| issn | 1471-2261 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
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| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-a5da21dec351496c8690642c1e185b852024-12-01T12:08:53ZengBMCBMC Cardiovascular Disorders1471-22612024-11-0124111010.1186/s12872-024-04348-2Serum total calcium levels as a non-linear predictor of in-hospital mortality in heart failure patients: insights from a retrospective cohort studyJing Song0Guojuan Xu1Jing Song2Guojuan Xu3Department of Cardiology, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Cardiology, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Cardiology, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Cardiology, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityAbstract Background Calcium is pivotal in the regulation of bodily homeostasis, with numerous studies highlighting its link to cardiovascular disease in the adult population. However, the relationship between serum calcium levels and the prognosis of heart failure (HF) patients is not clear. This study explored the association between serum total calcium (STC) and in-hospital mortality in patients with HF. Methods Clinical data of 1,176 patients with HF were obtained from the Multiparametric Intelligent Monitoring in Intensive Care III (MIMIC-III) database. The patients were categorized into STC quartiles, and baseline characteristics were comprehensively analyzed. Univariate and multivariate analyses were employed to identify factors associated with in-hospital mortality. To explore the non-linear relationship between STC and mortality, a two-piecewise linear regression model was applied. Subgroup analyses were conducted to identify potential confounding variables. Results In this cohort, 159 (13.53%) patients experienced in-hospital mortality. Significant differences in various parameters were observed among STC quartiles. Univariate analysis identified numerous factors associated with mortality. Multivariate analysis confirmed STC as an independent predictor of in-hospital mortality, with a negative association persisting even after adjusting for confounding factors (odds ratio [OR]: 0.49, 95%CI: 0.32–0.76; P = 0.0016). Non-linear analysis revealed an inflection point at 8.41 mg/dL, below which the risk of in-hospital death significantly increased (OR: 0.26, 95%CI: 0.12–0.55; P = 0.0005). Subgroup analyses indicated a pronounced inverse association in patients without atrial fibrillation or chronic obstructive pulmonary disease, as well as those with a left ventricular ejection fraction ≤ 50%. Conclusion This study identified STC as an independent predictor of in-hospital mortality in HF patients, with a non-linear relationship.https://doi.org/10.1186/s12872-024-04348-2Serum calciumMortalityCardiovascular diseaseRisk factorsPredictor |
| spellingShingle | Jing Song Guojuan Xu Jing Song Guojuan Xu Serum total calcium levels as a non-linear predictor of in-hospital mortality in heart failure patients: insights from a retrospective cohort study BMC Cardiovascular Disorders Serum calcium Mortality Cardiovascular disease Risk factors Predictor |
| title | Serum total calcium levels as a non-linear predictor of in-hospital mortality in heart failure patients: insights from a retrospective cohort study |
| title_full | Serum total calcium levels as a non-linear predictor of in-hospital mortality in heart failure patients: insights from a retrospective cohort study |
| title_fullStr | Serum total calcium levels as a non-linear predictor of in-hospital mortality in heart failure patients: insights from a retrospective cohort study |
| title_full_unstemmed | Serum total calcium levels as a non-linear predictor of in-hospital mortality in heart failure patients: insights from a retrospective cohort study |
| title_short | Serum total calcium levels as a non-linear predictor of in-hospital mortality in heart failure patients: insights from a retrospective cohort study |
| title_sort | serum total calcium levels as a non linear predictor of in hospital mortality in heart failure patients insights from a retrospective cohort study |
| topic | Serum calcium Mortality Cardiovascular disease Risk factors Predictor |
| url | https://doi.org/10.1186/s12872-024-04348-2 |
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