Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay

Abstract Legionella pneumophila, an intracellular bacterial pathogen, injects effector proteins into host cells to manipulate cellular processes and promote its survival and proliferation. Here, we reveal a unique mechanism by which the Legionella effector PieF perturbs host mRNA decay by targeting...

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Bibliographic Details
Main Authors: Yevgen Levdansky, Justin C. Deme, David J. Turner, Claire T. Piczak, Filip Pekovic, Anna L. Valkov, Sergey G. Tarasov, Susan M. Lea, Eugene Valkov
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61194-2
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