Role of N6-methyladenosine methylation in nasopharyngeal carcinoma: current insights and future prospective
Abstract Nasopharyngeal carcinoma (NPC) is a distinct type of head and neck squamous cell carcinoma prevalent in Southern China, Southeast Asia, and North Africa. Despite advances in treatment options, the prognosis for advanced NPC remains poor, underscoring the urgent need to explore its underlyin...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2024-12-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-024-02266-y |
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| author | YaYan Zhao Jie Li MeiJuan Dian YaNan Bie ZhiTao Peng Ying Zhou BingQian Zhou WeiChao Hao XiCheng Wang |
| author_facet | YaYan Zhao Jie Li MeiJuan Dian YaNan Bie ZhiTao Peng Ying Zhou BingQian Zhou WeiChao Hao XiCheng Wang |
| author_sort | YaYan Zhao |
| collection | DOAJ |
| description | Abstract Nasopharyngeal carcinoma (NPC) is a distinct type of head and neck squamous cell carcinoma prevalent in Southern China, Southeast Asia, and North Africa. Despite advances in treatment options, the prognosis for advanced NPC remains poor, underscoring the urgent need to explore its underlying mechanisms and develop novel therapeutic strategies. Epigenetic alterations have been shown to play a key role in NPC progression. Recent studies indicate that dysregulation of RNA modifications in NPC specifically affects tumor-related transcripts, influencing various oncogenic processes. This review provides a comprehensive overview of altered RNA modifications and their regulators in NPC, with a focus on m6A and its regulatory mechanisms. We discuss how m6A RNA modification influences gene expression and affects NPC initiation and progression at the molecular level, analyzing its impact on cancer-related biological functions. Understanding these modifications could reveal new biomarkers and therapeutic targets for NPC, offering promising directions for future research and precision medicine. |
| format | Article |
| id | doaj-art-a5b3fda65cdd44b8b25f881ecfeb951f |
| institution | Kabale University |
| issn | 2058-7716 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj-art-a5b3fda65cdd44b8b25f881ecfeb951f2024-12-22T12:15:30ZengNature Publishing GroupCell Death Discovery2058-77162024-12-0110112110.1038/s41420-024-02266-yRole of N6-methyladenosine methylation in nasopharyngeal carcinoma: current insights and future prospectiveYaYan Zhao0Jie Li1MeiJuan Dian2YaNan Bie3ZhiTao Peng4Ying Zhou5BingQian Zhou6WeiChao Hao7XiCheng Wang8Department of Oncology, The First Affiliated Hospital of Guangdong Pharmaceutical UniversityDepartment of Oncology, The First Affiliated Hospital of Guangdong Pharmaceutical UniversityDepartment of Thoracic Surgery, Nanfang Hospital, Southern Medical UniversitySchool of Basic Medical Sciences, Guangdong Pharmaceutical UniversityCancer Research Institute, School of Basic Medical Sciences, Southern Medical UniversityCancer Research Institute, School of Basic Medical Sciences, Southern Medical UniversityDepartment of Oncology, The First Affiliated Hospital of Guangdong Pharmaceutical UniversityDepartment of Oncology, The First Affiliated Hospital of Guangdong Pharmaceutical UniversityDepartment of Oncology, The First Affiliated Hospital of Guangdong Pharmaceutical UniversityAbstract Nasopharyngeal carcinoma (NPC) is a distinct type of head and neck squamous cell carcinoma prevalent in Southern China, Southeast Asia, and North Africa. Despite advances in treatment options, the prognosis for advanced NPC remains poor, underscoring the urgent need to explore its underlying mechanisms and develop novel therapeutic strategies. Epigenetic alterations have been shown to play a key role in NPC progression. Recent studies indicate that dysregulation of RNA modifications in NPC specifically affects tumor-related transcripts, influencing various oncogenic processes. This review provides a comprehensive overview of altered RNA modifications and their regulators in NPC, with a focus on m6A and its regulatory mechanisms. We discuss how m6A RNA modification influences gene expression and affects NPC initiation and progression at the molecular level, analyzing its impact on cancer-related biological functions. Understanding these modifications could reveal new biomarkers and therapeutic targets for NPC, offering promising directions for future research and precision medicine.https://doi.org/10.1038/s41420-024-02266-y |
| spellingShingle | YaYan Zhao Jie Li MeiJuan Dian YaNan Bie ZhiTao Peng Ying Zhou BingQian Zhou WeiChao Hao XiCheng Wang Role of N6-methyladenosine methylation in nasopharyngeal carcinoma: current insights and future prospective Cell Death Discovery |
| title | Role of N6-methyladenosine methylation in nasopharyngeal carcinoma: current insights and future prospective |
| title_full | Role of N6-methyladenosine methylation in nasopharyngeal carcinoma: current insights and future prospective |
| title_fullStr | Role of N6-methyladenosine methylation in nasopharyngeal carcinoma: current insights and future prospective |
| title_full_unstemmed | Role of N6-methyladenosine methylation in nasopharyngeal carcinoma: current insights and future prospective |
| title_short | Role of N6-methyladenosine methylation in nasopharyngeal carcinoma: current insights and future prospective |
| title_sort | role of n6 methyladenosine methylation in nasopharyngeal carcinoma current insights and future prospective |
| url | https://doi.org/10.1038/s41420-024-02266-y |
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