Unveiling immune resistance mechanisms in nasopharyngeal carcinoma and emerging targets for antitumor immune response: tertiary lymphoid structures
Abstract Nasopharyngeal carcinoma (NPC) is a prevalent malignancy in China, commonly associated with undifferentiated cell types and Epstein-Barr virus (EBV) infection. The presence of intense lymphocytic infiltration and elevated expression of programmed cell death ligand 1(PD-L1) in NPC highlights...
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BMC
2025-01-01
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Online Access: | https://doi.org/10.1186/s12967-024-05880-7 |
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author | Huilin Wang Yuting Zhan Jiadi Luo Weiyuan Wang Songqing Fan |
author_facet | Huilin Wang Yuting Zhan Jiadi Luo Weiyuan Wang Songqing Fan |
author_sort | Huilin Wang |
collection | DOAJ |
description | Abstract Nasopharyngeal carcinoma (NPC) is a prevalent malignancy in China, commonly associated with undifferentiated cell types and Epstein-Barr virus (EBV) infection. The presence of intense lymphocytic infiltration and elevated expression of programmed cell death ligand 1(PD-L1) in NPC highlights its potential for immunotherapy, yet current treatment outcomes remain suboptimal. In this review, we explore the tumor microenvironment of NPC to better understand the mechanisms of resistance to immunotherapy, evaluate current therapeutic strategies, and pinpoint emerging targets, such as tertiary lymphoid structures (TLSs), that could enhance treatment outcomes and prognostic accuracy. TLSs have demonstrated positive prognostic value in NPC, making them a promising target for future therapies. This review summarizes the key characteristics of TLSs and latest research in the context of NPC. We are optimistic that targeting TLSs could improve immunotherapy outcomes for NPC patients, ultimately leading to more effective treatment strategies and better patient survival. |
format | Article |
id | doaj-art-a5b2ba91b69f41f5bcf4bd724a94c95c |
institution | Kabale University |
issn | 1479-5876 |
language | English |
publishDate | 2025-01-01 |
publisher | BMC |
record_format | Article |
series | Journal of Translational Medicine |
spelling | doaj-art-a5b2ba91b69f41f5bcf4bd724a94c95c2025-01-12T12:37:52ZengBMCJournal of Translational Medicine1479-58762025-01-012311910.1186/s12967-024-05880-7Unveiling immune resistance mechanisms in nasopharyngeal carcinoma and emerging targets for antitumor immune response: tertiary lymphoid structuresHuilin Wang0Yuting Zhan1Jiadi Luo2Weiyuan Wang3Songqing Fan4Department of Pathology, The Second Xiangya Hospital, Central South UniversityDepartment of Pathology, The Second Xiangya Hospital, Central South UniversityDepartment of Pathology, The Second Xiangya Hospital, Central South UniversityDepartment of Pathology, Xiangya Hospital, Central South UniversityDepartment of Pathology, The Second Xiangya Hospital, Central South UniversityAbstract Nasopharyngeal carcinoma (NPC) is a prevalent malignancy in China, commonly associated with undifferentiated cell types and Epstein-Barr virus (EBV) infection. The presence of intense lymphocytic infiltration and elevated expression of programmed cell death ligand 1(PD-L1) in NPC highlights its potential for immunotherapy, yet current treatment outcomes remain suboptimal. In this review, we explore the tumor microenvironment of NPC to better understand the mechanisms of resistance to immunotherapy, evaluate current therapeutic strategies, and pinpoint emerging targets, such as tertiary lymphoid structures (TLSs), that could enhance treatment outcomes and prognostic accuracy. TLSs have demonstrated positive prognostic value in NPC, making them a promising target for future therapies. This review summarizes the key characteristics of TLSs and latest research in the context of NPC. We are optimistic that targeting TLSs could improve immunotherapy outcomes for NPC patients, ultimately leading to more effective treatment strategies and better patient survival.https://doi.org/10.1186/s12967-024-05880-7Nasopharyngeal carcinomaTertiary lymphoid structuresTumor microenvironmentImmunotherapy |
spellingShingle | Huilin Wang Yuting Zhan Jiadi Luo Weiyuan Wang Songqing Fan Unveiling immune resistance mechanisms in nasopharyngeal carcinoma and emerging targets for antitumor immune response: tertiary lymphoid structures Journal of Translational Medicine Nasopharyngeal carcinoma Tertiary lymphoid structures Tumor microenvironment Immunotherapy |
title | Unveiling immune resistance mechanisms in nasopharyngeal carcinoma and emerging targets for antitumor immune response: tertiary lymphoid structures |
title_full | Unveiling immune resistance mechanisms in nasopharyngeal carcinoma and emerging targets for antitumor immune response: tertiary lymphoid structures |
title_fullStr | Unveiling immune resistance mechanisms in nasopharyngeal carcinoma and emerging targets for antitumor immune response: tertiary lymphoid structures |
title_full_unstemmed | Unveiling immune resistance mechanisms in nasopharyngeal carcinoma and emerging targets for antitumor immune response: tertiary lymphoid structures |
title_short | Unveiling immune resistance mechanisms in nasopharyngeal carcinoma and emerging targets for antitumor immune response: tertiary lymphoid structures |
title_sort | unveiling immune resistance mechanisms in nasopharyngeal carcinoma and emerging targets for antitumor immune response tertiary lymphoid structures |
topic | Nasopharyngeal carcinoma Tertiary lymphoid structures Tumor microenvironment Immunotherapy |
url | https://doi.org/10.1186/s12967-024-05880-7 |
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