Sodium butyrate is incorporated into central metabolism in fly head while inducing oxygen consumption increase.
Butyrate has been proposed as a drug therapy by acting as a lysine deacetylase (KDAC) inhibitor and elevating protein acetylation, in particular on histones. Nonetheless, recent studies suggest that tissues such as the gut can utilize butyrate as a metabolite. We have previously shown that the addit...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0315892 |
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| author | Annika Müller-Eigner Benedikt Gille Frederik Dethloff Chen Meng Christina Ludwig John T Heiker Patrick Giavalisco Shahaf Peleg |
| author_facet | Annika Müller-Eigner Benedikt Gille Frederik Dethloff Chen Meng Christina Ludwig John T Heiker Patrick Giavalisco Shahaf Peleg |
| author_sort | Annika Müller-Eigner |
| collection | DOAJ |
| description | Butyrate has been proposed as a drug therapy by acting as a lysine deacetylase (KDAC) inhibitor and elevating protein acetylation, in particular on histones. Nonetheless, recent studies suggest that tissues such as the gut can utilize butyrate as a metabolite. We have previously shown that the addition of butyrate induces a rapid increase of oxygen consumption in whole Drosophila melanogaster heads. Here we show that while head oxygen consumption is increased by the addition of butyrate, no apparent changes are observed on the proteome and acetylome. Instead, we show that butyrate is metabolized and incorporated into the tricarboxylic acid (TCA) cycle. Collectively our data supports the notion that the therapeutic benefits of acute butyrate treatment may be also mediated by improving metabolic rates, rather than solely targeting the epigenome or acetylome. |
| format | Article |
| id | doaj-art-a58a649d71804e29bab59a6eee80fff2 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-a58a649d71804e29bab59a6eee80fff22025-01-08T05:32:52ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-011912e031589210.1371/journal.pone.0315892Sodium butyrate is incorporated into central metabolism in fly head while inducing oxygen consumption increase.Annika Müller-EignerBenedikt GilleFrederik DethloffChen MengChristina LudwigJohn T HeikerPatrick GiavaliscoShahaf PelegButyrate has been proposed as a drug therapy by acting as a lysine deacetylase (KDAC) inhibitor and elevating protein acetylation, in particular on histones. Nonetheless, recent studies suggest that tissues such as the gut can utilize butyrate as a metabolite. We have previously shown that the addition of butyrate induces a rapid increase of oxygen consumption in whole Drosophila melanogaster heads. Here we show that while head oxygen consumption is increased by the addition of butyrate, no apparent changes are observed on the proteome and acetylome. Instead, we show that butyrate is metabolized and incorporated into the tricarboxylic acid (TCA) cycle. Collectively our data supports the notion that the therapeutic benefits of acute butyrate treatment may be also mediated by improving metabolic rates, rather than solely targeting the epigenome or acetylome.https://doi.org/10.1371/journal.pone.0315892 |
| spellingShingle | Annika Müller-Eigner Benedikt Gille Frederik Dethloff Chen Meng Christina Ludwig John T Heiker Patrick Giavalisco Shahaf Peleg Sodium butyrate is incorporated into central metabolism in fly head while inducing oxygen consumption increase. PLoS ONE |
| title | Sodium butyrate is incorporated into central metabolism in fly head while inducing oxygen consumption increase. |
| title_full | Sodium butyrate is incorporated into central metabolism in fly head while inducing oxygen consumption increase. |
| title_fullStr | Sodium butyrate is incorporated into central metabolism in fly head while inducing oxygen consumption increase. |
| title_full_unstemmed | Sodium butyrate is incorporated into central metabolism in fly head while inducing oxygen consumption increase. |
| title_short | Sodium butyrate is incorporated into central metabolism in fly head while inducing oxygen consumption increase. |
| title_sort | sodium butyrate is incorporated into central metabolism in fly head while inducing oxygen consumption increase |
| url | https://doi.org/10.1371/journal.pone.0315892 |
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