Belatacept and regulatory T cells in transplantation: synergistic strategies for immune tolerance and graft survival
Calcineurin inhibitors (CNIs) have been a cornerstone in solid organ transplantation for many years; however, their prolonged use is linked to significant adverse effects, most notably nephrotoxicity. Belatacept, a modified version of cytotoxic T lymphocyte antigen-4 immunoglobulin with increased bi...
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| Format: | Article |
| Language: | English |
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The Korean Society for Transplantation
2024-12-01
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| Series: | Clinical Transplantation and Research |
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| Online Access: | https://www.ctrjournal.org/journal/view.html?doi=10.4285/ctr.24.0057 |
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| author | Gil-Ran Kim Kyung-Ho Nam Je-Min Choi |
| author_facet | Gil-Ran Kim Kyung-Ho Nam Je-Min Choi |
| author_sort | Gil-Ran Kim |
| collection | DOAJ |
| description | Calcineurin inhibitors (CNIs) have been a cornerstone in solid organ transplantation for many years; however, their prolonged use is linked to significant adverse effects, most notably nephrotoxicity. Belatacept, a modified version of cytotoxic T lymphocyte antigen-4 immunoglobulin with increased binding affinity for its ligand, has emerged as a viable alternative to traditional CNIs due to its lower toxicity profile. Despite these benefits, belatacept is associated with a higher rate of acute rejection, which presents a challenge for long-term graft survival. This review reevaluates the limitations of belatacept in achieving long-term acceptance of transplants and highlights the importance of regulatory T (Treg) cells in maintaining immune tolerance and preventing graft rejection. Additionally, it discusses the potential benefits of combining therapies that boost Treg cells with belatacept to increase the effectiveness of immunosuppression and improve graft outcomes. |
| format | Article |
| id | doaj-art-a586318709b746d5a5465b3a8e88dd72 |
| institution | Kabale University |
| issn | 3022-6783 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | The Korean Society for Transplantation |
| record_format | Article |
| series | Clinical Transplantation and Research |
| spelling | doaj-art-a586318709b746d5a5465b3a8e88dd722025-01-15T02:51:59ZengThe Korean Society for TransplantationClinical Transplantation and Research3022-67832024-12-0138432634010.4285/ctr.24.0057ctr.24.0057Belatacept and regulatory T cells in transplantation: synergistic strategies for immune tolerance and graft survivalGil-Ran Kim0Kyung-Ho Nam1Je-Min Choi2Department of Life Science, College of Natural Sciences, Hanyang University, Seoul, KoreaDepartment of Life Science, College of Natural Sciences, Hanyang University, Seoul, KoreaDepartment of Life Science, College of Natural Sciences, Hanyang University, Seoul, KoreaCalcineurin inhibitors (CNIs) have been a cornerstone in solid organ transplantation for many years; however, their prolonged use is linked to significant adverse effects, most notably nephrotoxicity. Belatacept, a modified version of cytotoxic T lymphocyte antigen-4 immunoglobulin with increased binding affinity for its ligand, has emerged as a viable alternative to traditional CNIs due to its lower toxicity profile. Despite these benefits, belatacept is associated with a higher rate of acute rejection, which presents a challenge for long-term graft survival. This review reevaluates the limitations of belatacept in achieving long-term acceptance of transplants and highlights the importance of regulatory T (Treg) cells in maintaining immune tolerance and preventing graft rejection. Additionally, it discusses the potential benefits of combining therapies that boost Treg cells with belatacept to increase the effectiveness of immunosuppression and improve graft outcomes.https://www.ctrjournal.org/journal/view.html?doi=10.4285/ctr.24.0057abatacept; transplantation; regulatory t cells |
| spellingShingle | Gil-Ran Kim Kyung-Ho Nam Je-Min Choi Belatacept and regulatory T cells in transplantation: synergistic strategies for immune tolerance and graft survival Clinical Transplantation and Research abatacept; transplantation; regulatory t cells |
| title | Belatacept and regulatory T cells in transplantation: synergistic strategies for immune tolerance and graft survival |
| title_full | Belatacept and regulatory T cells in transplantation: synergistic strategies for immune tolerance and graft survival |
| title_fullStr | Belatacept and regulatory T cells in transplantation: synergistic strategies for immune tolerance and graft survival |
| title_full_unstemmed | Belatacept and regulatory T cells in transplantation: synergistic strategies for immune tolerance and graft survival |
| title_short | Belatacept and regulatory T cells in transplantation: synergistic strategies for immune tolerance and graft survival |
| title_sort | belatacept and regulatory t cells in transplantation synergistic strategies for immune tolerance and graft survival |
| topic | abatacept; transplantation; regulatory t cells |
| url | https://www.ctrjournal.org/journal/view.html?doi=10.4285/ctr.24.0057 |
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