Non-melanoma skin cancer treated with hypofractionated 192—Ir contact brachitherapy: a single institution series

Non-melanoma skin cancer treated with hypofractionated 192—Ir contact brachitherapy: a single institution series

BackgroundNon-melanoma skin carcinoma (NMSC) is the most common malignant tumor in the population, with a steadily increasing incidence due to an aging population and sun exposure. The two main subtypes of NMSC are basal cell carcinoma(BCC) and squamous cell carcinoma(SCC). Therapeutic management of...

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Main Authors: Elisa Ciurlia, Bianca Santo, Maria Cristina Barba, Elisa Cavalera, Paola De Franco, Sara De Matteis, Giuseppe Di Paola, Angela Leone, Antonella Papaleo, Dino Rubini, Donatella Russo, Giuseppe Rubini, Angela Sardaro
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Oncology
Subjects:
non-melanoma skin carcinoma
basal cell carcinoma
squamous cell carcinoma
high-dose fractionated contact brachytherapy
personalization of treatment
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1525926/full
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Summary:BackgroundNon-melanoma skin carcinoma (NMSC) is the most common malignant tumor in the population, with a steadily increasing incidence due to an aging population and sun exposure. The two main subtypes of NMSC are basal cell carcinoma(BCC) and squamous cell carcinoma(SCC). Therapeutic management of NMSC includes a variety of options, such as surgery, radiotherapy, and topical or systemic treatments. High-dose fractionated contact brachytherapy (c-HDR-BRT) is a viable therapeutic option for treating NMSCs.MethodsAt our center, we treated 39 patients with BCC or SCC, with a total of 46 lesions, treated with c-HDR-BRT. The patients underwent two different radiotherapy schedules: 40 Gy in four fractions and 30 Gy in three fractions.ResultsTwo-year results showed 100% local control (LC) and 100% disease-specific survival (DSS), indicating high efficacy of c-HDR-BRT in terms of tumor control. Furthermore, the observed toxicity profile was favorable with no significant late toxicity.ConclusionsThese results suggest that c-HDR-BRT represents a viable therapeutic alternative for NMSC, combining high oncological efficacy with an acceptable safety profile, while minimizing the aesthetic and functional impact of therapy. Finally, the study emphasizes the importance of personalization of treatment and careful evaluation of individual cases to optimize the treatment approach in NMSC.
ISSN:2234-943X

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