Meta-analysis of the efficacy of glucagon-like peptide-1 receptor agonists in the treatment of diabetic nephropathy
Objective To systematically evaluate the efficacy of glucagon-like peptide-1 receptor agonists（Glp-1 ras） in the treatment of Diabetic Kidney Disease（DKD）. Methods Foreign language databases such as Pub Med, EMbase and Cochrane Library, and Chinese databases such as Wanfang data, China National Know...
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Editorial Department of Journal of Clinical Nephrology
2024-12-01
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| Series: | Linchuang shenzangbing zazhi |
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| Online Access: | http://www.lcszb.com/cn/article/doi/10.3969/j.issn.1671-2390.2024.12.003 |
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| author | Ze-jin Liao Jin-hu Chen Li-hua Ni Xiao-yan Wu |
| author_facet | Ze-jin Liao Jin-hu Chen Li-hua Ni Xiao-yan Wu |
| author_sort | Ze-jin Liao |
| collection | DOAJ |
| description | Objective To systematically evaluate the efficacy of glucagon-like peptide-1 receptor agonists（Glp-1 ras） in the treatment of Diabetic Kidney Disease（DKD）. Methods Foreign language databases such as Pub Med, EMbase and Cochrane Library, and Chinese databases such as Wanfang data, China National Knowledge Infrastructure Project, Chinese biomedical literature service system and VIP periodical resource integration service platform were searched. The quality of the included studies was assessed according to the quality assessment criteria of the Cochrane handbook, and the data were analyzed by Rev Man 5.3 software. Results Thirteen randomized controlled trials involving 1136 DKD patients were finally included. The results showed that the glucagon-like peptide-1 receptor agonist treatment group significantly improved 24-h urinary protein[MD=−13.44, 95%CI（−17.09, −9.79）, I2=5%, P＜0.00001], urinary albumin/creatinine ratio[MD=−15.27, 95%CI（−17.12, −13.42）, I2=88%, P＜0.00001], blood-urea-nitrogen[MD=−1.21, 95%CI（−1.41, −1.00）, I2=27%, P＜0.00001], glycosylated hemoglobin[SMD=−1.12, 95%CI（−1.31, −0.94）, I2=38%, P＜0.00001], Serum creatinine[MD=−7.55, 95%CI（−9.92, −5.17）, I2=19%, P＜0.00001], total serum cholesterol[MD=−0.56, 95%CI（−0.70, −0.42）, I2=30%, P＜0.00001], and body mass index[MD=−3.61, 95%CI（−4.47, −2.76）, I2=0%, P＜0.00001, the differences were statistically significant. ConclusionGlucagon-like peptide-1 receptor agonists have good efficacy in the treatment of diabetic nephropathy, with a significant effect on changing renal outcomes and improving metabolic levels, although higher quality evidence is needed for validation. |
| format | Article |
| id | doaj-art-a57612f4cd4746b6a7346fec282dea88 |
| institution | Kabale University |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2024-12-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-a57612f4cd4746b6a7346fec282dea882024-12-26T03:15:58ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902024-12-01241298399210.3969/j.issn.1671-2390.2024.12.00320240030Meta-analysis of the efficacy of glucagon-like peptide-1 receptor agonists in the treatment of diabetic nephropathyZe-jin Liao0Jin-hu Chen1Li-hua Ni2Xiao-yan Wu3Department of Nephrology, Zhongnan Hospital, Wuhan University, Wuhan 430071, ChinaDepartment of Nephrology, Zhongnan Hospital, Wuhan University, Wuhan 430071, ChinaDepartment of Nephrology, Zhongnan Hospital, Wuhan University, Wuhan 430071, ChinaDepartment of Nephrology, Zhongnan Hospital, Wuhan University, Wuhan 430071, ChinaObjective To systematically evaluate the efficacy of glucagon-like peptide-1 receptor agonists（Glp-1 ras） in the treatment of Diabetic Kidney Disease（DKD）. Methods Foreign language databases such as Pub Med, EMbase and Cochrane Library, and Chinese databases such as Wanfang data, China National Knowledge Infrastructure Project, Chinese biomedical literature service system and VIP periodical resource integration service platform were searched. The quality of the included studies was assessed according to the quality assessment criteria of the Cochrane handbook, and the data were analyzed by Rev Man 5.3 software. Results Thirteen randomized controlled trials involving 1136 DKD patients were finally included. The results showed that the glucagon-like peptide-1 receptor agonist treatment group significantly improved 24-h urinary protein[MD=−13.44, 95%CI（−17.09, −9.79）, I2=5%, P＜0.00001], urinary albumin/creatinine ratio[MD=−15.27, 95%CI（−17.12, −13.42）, I2=88%, P＜0.00001], blood-urea-nitrogen[MD=−1.21, 95%CI（−1.41, −1.00）, I2=27%, P＜0.00001], glycosylated hemoglobin[SMD=−1.12, 95%CI（−1.31, −0.94）, I2=38%, P＜0.00001], Serum creatinine[MD=−7.55, 95%CI（−9.92, −5.17）, I2=19%, P＜0.00001], total serum cholesterol[MD=−0.56, 95%CI（−0.70, −0.42）, I2=30%, P＜0.00001], and body mass index[MD=−3.61, 95%CI（−4.47, −2.76）, I2=0%, P＜0.00001, the differences were statistically significant. ConclusionGlucagon-like peptide-1 receptor agonists have good efficacy in the treatment of diabetic nephropathy, with a significant effect on changing renal outcomes and improving metabolic levels, although higher quality evidence is needed for validation.http://www.lcszb.com/cn/article/doi/10.3969/j.issn.1671-2390.2024.12.003glucagon-like peptide-1 receptor agonistdiabetic kidney diseasemeta analysis |
| spellingShingle | Ze-jin Liao Jin-hu Chen Li-hua Ni Xiao-yan Wu Meta-analysis of the efficacy of glucagon-like peptide-1 receptor agonists in the treatment of diabetic nephropathy Linchuang shenzangbing zazhi glucagon-like peptide-1 receptor agonist diabetic kidney disease meta analysis |
| title | Meta-analysis of the efficacy of glucagon-like peptide-1 receptor agonists in the treatment of diabetic nephropathy |
| title_full | Meta-analysis of the efficacy of glucagon-like peptide-1 receptor agonists in the treatment of diabetic nephropathy |
| title_fullStr | Meta-analysis of the efficacy of glucagon-like peptide-1 receptor agonists in the treatment of diabetic nephropathy |
| title_full_unstemmed | Meta-analysis of the efficacy of glucagon-like peptide-1 receptor agonists in the treatment of diabetic nephropathy |
| title_short | Meta-analysis of the efficacy of glucagon-like peptide-1 receptor agonists in the treatment of diabetic nephropathy |
| title_sort | meta analysis of the efficacy of glucagon like peptide 1 receptor agonists in the treatment of diabetic nephropathy |
| topic | glucagon-like peptide-1 receptor agonist diabetic kidney disease meta analysis |
| url | http://www.lcszb.com/cn/article/doi/10.3969/j.issn.1671-2390.2024.12.003 |
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