Resolution dependence of vessel size index across various brain regions
Magnetic resonance imaging (MRI) excels at detecting quantitative changes in microvascular parameters such as cerebral blood volume, cerebral blood flow, and vessel size index (VSI), which are essential for diagnosing and monitoring cerebrovascular diseases. Absolute VSI estimation, often utilizing...
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Elsevier
2025-01-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811924004762 |
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| author | DongKyu Lee Yelim Gong Abel Worku Tessema SoHyun Han Hyung Joon Cho |
| author_facet | DongKyu Lee Yelim Gong Abel Worku Tessema SoHyun Han Hyung Joon Cho |
| author_sort | DongKyu Lee |
| collection | DOAJ |
| description | Magnetic resonance imaging (MRI) excels at detecting quantitative changes in microvascular parameters such as cerebral blood volume, cerebral blood flow, and vessel size index (VSI), which are essential for diagnosing and monitoring cerebrovascular diseases. Absolute VSI estimation, often utilizing superparamagnetic iron oxide nanoparticles as contrast agents, relies on measuring transverse relaxation rates (∆R2⁎ and ∆R2). This study systematically investigates the spatial resolution dependence of VSI using Monte Carlo simulations and in vivo rat brain MRI experiments. Monte Carlo simulations modeled randomly oriented vasculatures with various vessel sizes, revealing that ∆R2 values are significantly higher at an in-plane spatial resolution of 125 × 125 µm² compared to lower resolutions, particularly for smaller vessels. In vivo experiments on 13 rats using a 7 T MRI scanner compared VSI measurements at spatial resolutions of 125 µm² and 250 µm² across different brain regions. Results indicated region-specific VSI variations, with smaller vessels showing more pronounced resolution-dependent changes. The corpus callosum and hippocampal formation regions in particular exhibited significant increases in VSI at lower resolutions. The observed variability is attributed to the differing sensitivities of ΔR2⁎ and ΔR2 to vessel size. Corroboration between the experimental data and simulation findings emphasizes the necessity of optimizing spatial resolution to ensure accurate VSI quantification and enhance the precision of neuro-microvascular imaging techniques. |
| format | Article |
| id | doaj-art-a57123e4555748ae9475e9f587cd9d3a |
| institution | Kabale University |
| issn | 1095-9572 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj-art-a57123e4555748ae9475e9f587cd9d3a2025-01-11T06:38:33ZengElsevierNeuroImage1095-95722025-01-01305120979Resolution dependence of vessel size index across various brain regionsDongKyu Lee0Yelim Gong1Abel Worku Tessema2SoHyun Han3Hyung Joon Cho4Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea; Brain Tech Center, Korea Brain Research Institute, Daegu, Republic of KoreaDepartment of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea; Department of Medical Information, Chung-Ang University Gwangmyeong Hospital, Gyeonggi-do, Republic of KoreaDepartment of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Republic of KoreaCenter for Bio-imaging and Translational Research, Korea Basic Science Institute, Cheongju, Republic of Korea; Corresponding author at: Korea Basic Science Institute, Cheongju, Republic of Korea.Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea; Corresponding author at: 105-222, 50 UNIST-gil, Eonyang-eup, Ulju-gun, Ulsan, Republic of Korea.Magnetic resonance imaging (MRI) excels at detecting quantitative changes in microvascular parameters such as cerebral blood volume, cerebral blood flow, and vessel size index (VSI), which are essential for diagnosing and monitoring cerebrovascular diseases. Absolute VSI estimation, often utilizing superparamagnetic iron oxide nanoparticles as contrast agents, relies on measuring transverse relaxation rates (∆R2⁎ and ∆R2). This study systematically investigates the spatial resolution dependence of VSI using Monte Carlo simulations and in vivo rat brain MRI experiments. Monte Carlo simulations modeled randomly oriented vasculatures with various vessel sizes, revealing that ∆R2 values are significantly higher at an in-plane spatial resolution of 125 × 125 µm² compared to lower resolutions, particularly for smaller vessels. In vivo experiments on 13 rats using a 7 T MRI scanner compared VSI measurements at spatial resolutions of 125 µm² and 250 µm² across different brain regions. Results indicated region-specific VSI variations, with smaller vessels showing more pronounced resolution-dependent changes. The corpus callosum and hippocampal formation regions in particular exhibited significant increases in VSI at lower resolutions. The observed variability is attributed to the differing sensitivities of ΔR2⁎ and ΔR2 to vessel size. Corroboration between the experimental data and simulation findings emphasizes the necessity of optimizing spatial resolution to ensure accurate VSI quantification and enhance the precision of neuro-microvascular imaging techniques.http://www.sciencedirect.com/science/article/pii/S1053811924004762Vessel size imagingVessel size indexPartial volume averagingResolution dependence |
| spellingShingle | DongKyu Lee Yelim Gong Abel Worku Tessema SoHyun Han Hyung Joon Cho Resolution dependence of vessel size index across various brain regions NeuroImage Vessel size imaging Vessel size index Partial volume averaging Resolution dependence |
| title | Resolution dependence of vessel size index across various brain regions |
| title_full | Resolution dependence of vessel size index across various brain regions |
| title_fullStr | Resolution dependence of vessel size index across various brain regions |
| title_full_unstemmed | Resolution dependence of vessel size index across various brain regions |
| title_short | Resolution dependence of vessel size index across various brain regions |
| title_sort | resolution dependence of vessel size index across various brain regions |
| topic | Vessel size imaging Vessel size index Partial volume averaging Resolution dependence |
| url | http://www.sciencedirect.com/science/article/pii/S1053811924004762 |
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