Multifunctional exosome-driven pancreatic cancer diagnostics and therapeutics
Pancreatic cancer (PC) remains one of the most common causes of cancer death. The overall survival rate of PC is relatively low. PC frequently presents in patients with nonspecific symptoms at the localized stage and PC patients are mostly diagnosed at an advanced stage. Therefore, the early diagnos...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Extracellular Vesicle |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S277304172300001X |
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| author | Sitong Zhang Danyang Li Yingjia Liu Chunlian Qin Lingjun Tong Lizhou Xu |
| author_facet | Sitong Zhang Danyang Li Yingjia Liu Chunlian Qin Lingjun Tong Lizhou Xu |
| author_sort | Sitong Zhang |
| collection | DOAJ |
| description | Pancreatic cancer (PC) remains one of the most common causes of cancer death. The overall survival rate of PC is relatively low. PC frequently presents in patients with nonspecific symptoms at the localized stage and PC patients are mostly diagnosed at an advanced stage. Therefore, the early diagnosis and treatment of suspected PC patients with or without symptoms are of significant importance for improving both patient prognosis and survival rate. Exosomes are smaller nano-sized extracellular vesicles that are secreted from cells for cellular communication. Exosomes are increasingly recognized as a promising new generation of biomarkers for PC detection, especially in the early stages. Owning to their carriage of endogenous proteins, nucleic acids, and other contents from releasing parent cells, such as cancer cell, which exosomes are believed to be tightly associated with clinically relevant cancer processes. Meanwhile, exosomes are potential drug delivery systems for therapeutics due to their natural origin and their ability to encapsulate biological molecules, including proteins and RNAs, within the double-layer lipid membrane. In this review, the multifunctional roles of exosomes in PC are summarized. Moreover, we further discuss the novel exosome-based diagnostic and therapeutic strategies for PC. Finally, the future perspective on using exosomes to facilitate PC diagnosis and therapeutics is highlighted. |
| format | Article |
| id | doaj-art-a55a883cb0a5452cbe2d5a560ce5e8e8 |
| institution | Kabale University |
| issn | 2773-0417 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Extracellular Vesicle |
| spelling | doaj-art-a55a883cb0a5452cbe2d5a560ce5e8e82024-11-23T06:34:51ZengElsevierExtracellular Vesicle2773-04172023-12-012100022Multifunctional exosome-driven pancreatic cancer diagnostics and therapeuticsSitong Zhang0Danyang Li1Yingjia Liu2Chunlian Qin3Lingjun Tong4Lizhou Xu5School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 119228, SingaporeThe Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, ChinaZJU-Hangzhou Global Scientific and Technological Innovation Center, Hangzhou 311200, ChinaZJU-Hangzhou Global Scientific and Technological Innovation Center, Hangzhou 311200, ChinaMedical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China; Corresponding authors.ZJU-Hangzhou Global Scientific and Technological Innovation Center, Hangzhou 311200, China; Corresponding authors.Pancreatic cancer (PC) remains one of the most common causes of cancer death. The overall survival rate of PC is relatively low. PC frequently presents in patients with nonspecific symptoms at the localized stage and PC patients are mostly diagnosed at an advanced stage. Therefore, the early diagnosis and treatment of suspected PC patients with or without symptoms are of significant importance for improving both patient prognosis and survival rate. Exosomes are smaller nano-sized extracellular vesicles that are secreted from cells for cellular communication. Exosomes are increasingly recognized as a promising new generation of biomarkers for PC detection, especially in the early stages. Owning to their carriage of endogenous proteins, nucleic acids, and other contents from releasing parent cells, such as cancer cell, which exosomes are believed to be tightly associated with clinically relevant cancer processes. Meanwhile, exosomes are potential drug delivery systems for therapeutics due to their natural origin and their ability to encapsulate biological molecules, including proteins and RNAs, within the double-layer lipid membrane. In this review, the multifunctional roles of exosomes in PC are summarized. Moreover, we further discuss the novel exosome-based diagnostic and therapeutic strategies for PC. Finally, the future perspective on using exosomes to facilitate PC diagnosis and therapeutics is highlighted.http://www.sciencedirect.com/science/article/pii/S277304172300001XExosomesPancreatic cancerDiagnosisTherapyBiomarker |
| spellingShingle | Sitong Zhang Danyang Li Yingjia Liu Chunlian Qin Lingjun Tong Lizhou Xu Multifunctional exosome-driven pancreatic cancer diagnostics and therapeutics Extracellular Vesicle Exosomes Pancreatic cancer Diagnosis Therapy Biomarker |
| title | Multifunctional exosome-driven pancreatic cancer diagnostics and therapeutics |
| title_full | Multifunctional exosome-driven pancreatic cancer diagnostics and therapeutics |
| title_fullStr | Multifunctional exosome-driven pancreatic cancer diagnostics and therapeutics |
| title_full_unstemmed | Multifunctional exosome-driven pancreatic cancer diagnostics and therapeutics |
| title_short | Multifunctional exosome-driven pancreatic cancer diagnostics and therapeutics |
| title_sort | multifunctional exosome driven pancreatic cancer diagnostics and therapeutics |
| topic | Exosomes Pancreatic cancer Diagnosis Therapy Biomarker |
| url | http://www.sciencedirect.com/science/article/pii/S277304172300001X |
| work_keys_str_mv | AT sitongzhang multifunctionalexosomedrivenpancreaticcancerdiagnosticsandtherapeutics AT danyangli multifunctionalexosomedrivenpancreaticcancerdiagnosticsandtherapeutics AT yingjialiu multifunctionalexosomedrivenpancreaticcancerdiagnosticsandtherapeutics AT chunlianqin multifunctionalexosomedrivenpancreaticcancerdiagnosticsandtherapeutics AT lingjuntong multifunctionalexosomedrivenpancreaticcancerdiagnosticsandtherapeutics AT lizhouxu multifunctionalexosomedrivenpancreaticcancerdiagnosticsandtherapeutics |