Poly-β-D-(1,6)-N-acetyl-glucosamine (PNAG) glycan vaccines with broad spectrum neutralizing activities

Poly-β-D-(1,6)-N-acetyl-glucosamine (PNAG) glycan vaccines with broad spectrum neutralizing activities

Abstract The development of bacterial vaccines is a complex challenge due to the substantial serological diversity of protective antigens. One promising antigenic target is the conserved surface polysaccharide poly-β-(1,6)-N-acetyl-D-glucosamine (PNAG). Despite its widespread distribution, antibodie...

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Main Authors: Kuo-Shiang Liao, Mu-Rong Kao, Tzu-Hsuan Ma, Mei-Hua Hsu, Tzu-Yin Chen, Balázs Imre, Philip J. Harris, Jiun-Jie Shie, Cheng-Hsun Chiu, Chung-Yi Wu, Yves S. Y. Hsieh
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61559-7
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