Thymines opposite to bulky aristolactam-DNA adducts in duplex DNA are not targeted by human thymine-DNA glycosylase

Thymines opposite to bulky aristolactam-DNA adducts in duplex DNA are not targeted by human thymine-DNA glycosylase

Background Consumption of aristolochic acids (AA) from the plant Aristolochia results in the formation of bulky aristolactam-dA (dA-AL) and aristolactam-dG (dG-AL) adducts in cellular DNA ultimately leading to the development of urothelial cancer. Intriguingly, the dA-AL adducts induce A•T→T•A trans...

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Main Authors: Diana Manapkyzy, Gulzhan Zhamanbayeva, Viktoriya Sidorenko, Radha Bonala, Francis Johnson, Bakhyt T. Matkarimov, Dmitry Zharkov, Murat K. Saparbaev, Sabira Taipakova
Format: Article
Language:English
Published: PeerJ Inc. 2025-07-01
Series:PeerJ
Subjects:
DNA glycosylase
DNA repair
Base excision repair
Aristolochic acid
Aristolactam-adenine adduct
T to A transversions
Online Access:https://peerj.com/articles/19577.pdf
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