Evaluating IgG Levels, Vaccination Effects, and COVID-19 Infection Severity in Renal Transplant Recipients
Several studies have reported that different factors play an important role in the production of IgG after VOVID-19 vaccination. This study aimed at studying COVID-19 infection rates and severity in renal transplant recipients and vaccine responsiveness. comorbidity hemodialysis requirements, and im...
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2024-06-01
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| author | Zana Mohammed Awny Jafar Ahmed Majeed Hussein Mustafa Domiana Shamoon Warda Masood Ahmed Hameed Nawfal R. Hussein |
| author_facet | Zana Mohammed Awny Jafar Ahmed Majeed Hussein Mustafa Domiana Shamoon Warda Masood Ahmed Hameed Nawfal R. Hussein |
| author_sort | Zana Mohammed |
| collection | DOAJ |
| description | Several studies have reported that different factors play an important role in the production of IgG after VOVID-19 vaccination. This study aimed at studying COVID-19 infection rates and severity in renal transplant recipients and vaccine responsiveness. comorbidity hemodialysis requirements, and immune suppression treatment regimens. In this cross-sectional study, IgG levels was measured in renal transplant recipients using automated benchtop immunoanalyzer Vidas at the Duhok Center for Kidney Disease and Transplantation. In this study group, only 30 individuals experienced the SARS-COVID-2 infection, with only three cases being severe. The most frequently reported symptoms of SARS-COVID-2 virus infection were fatigue (18/30) 60%, high temperature (17/30) 56%, headache (12/30) 40%, and poor endurance (11/30) 36.6%. The IgG titers were significantly different between the vaccinated 33.067 ± 2.5 versus unvaccinated individuals 23.916 ± 3.31with p value = 0.025. On the other hand, demographic characteristics of the cohort including: comorbidities, hemodialysis, different age groups, gender, infection/no-infection differences had no statistically significant impact on the IgG titers. Vaccination significantly increased the levels of protective IgG level in kidney transplant recipients. It is crucial to focus on increasing the acceptance of vaccination among kidney transplant recipients to prevent infections from other COVID-19 variants or pathogen outbreaks. |
| format | Article |
| id | doaj-art-a51536c5a436410da8da3f2b70abb13f |
| institution | Kabale University |
| issn | 2960-1428 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | QAASPA Publisher |
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| series | BioMed Target Journal |
| spelling | doaj-art-a51536c5a436410da8da3f2b70abb13f2025-01-10T21:54:26ZengQAASPA PublisherBioMed Target Journal2960-14282024-06-0121303410.59786/bmtj.2148Evaluating IgG Levels, Vaccination Effects, and COVID-19 Infection Severity in Renal Transplant RecipientsZana Mohammed0https://orcid.org/0009-0002-8841-0292Awny Jafar Ahmed1https://orcid.org/0009-0006-3919-596XMajeed Hussein Mustafa2https://orcid.org/0009-0007-2874-5329Domiana Shamoon Warda3https://orcid.org/0009-0004-6126-0786Masood Ahmed Hameed4https://orcid.org/0009-0004-3883-3590Nawfal R. Hussein5https://orcid.org/0000-0002-7813-9198Department of Internal Medicine, College of Medicine, University of Duhok, Duhok, 42001, IraqHeevi Teaching Hospital, Directorate General of Health, Duhok, 42001, IraqCollege of Nursing, University of Duhok, Duhok, 44001, IraqAzadi Teaching Hospital, Directorate General of Health, Duhok, 42001, IraqDepartment of Biomedical Sciences, College of Medicine, University of Zakho, Zakho, 42002, IraqDepartment of Biomedical Sciences, College of Medicine, University of Zakho, Zakho, 42002, IraqSeveral studies have reported that different factors play an important role in the production of IgG after VOVID-19 vaccination. This study aimed at studying COVID-19 infection rates and severity in renal transplant recipients and vaccine responsiveness. comorbidity hemodialysis requirements, and immune suppression treatment regimens. In this cross-sectional study, IgG levels was measured in renal transplant recipients using automated benchtop immunoanalyzer Vidas at the Duhok Center for Kidney Disease and Transplantation. In this study group, only 30 individuals experienced the SARS-COVID-2 infection, with only three cases being severe. The most frequently reported symptoms of SARS-COVID-2 virus infection were fatigue (18/30) 60%, high temperature (17/30) 56%, headache (12/30) 40%, and poor endurance (11/30) 36.6%. The IgG titers were significantly different between the vaccinated 33.067 ± 2.5 versus unvaccinated individuals 23.916 ± 3.31with p value = 0.025. On the other hand, demographic characteristics of the cohort including: comorbidities, hemodialysis, different age groups, gender, infection/no-infection differences had no statistically significant impact on the IgG titers. Vaccination significantly increased the levels of protective IgG level in kidney transplant recipients. It is crucial to focus on increasing the acceptance of vaccination among kidney transplant recipients to prevent infections from other COVID-19 variants or pathogen outbreaks.https://qaaspa.com/index.php/bmtj/article/view/8rental transplantcovid-19vaccinationimmunosuppression |
| spellingShingle | Zana Mohammed Awny Jafar Ahmed Majeed Hussein Mustafa Domiana Shamoon Warda Masood Ahmed Hameed Nawfal R. Hussein Evaluating IgG Levels, Vaccination Effects, and COVID-19 Infection Severity in Renal Transplant Recipients BioMed Target Journal rental transplant covid-19 vaccination immunosuppression |
| title | Evaluating IgG Levels, Vaccination Effects, and COVID-19 Infection Severity in Renal Transplant Recipients |
| title_full | Evaluating IgG Levels, Vaccination Effects, and COVID-19 Infection Severity in Renal Transplant Recipients |
| title_fullStr | Evaluating IgG Levels, Vaccination Effects, and COVID-19 Infection Severity in Renal Transplant Recipients |
| title_full_unstemmed | Evaluating IgG Levels, Vaccination Effects, and COVID-19 Infection Severity in Renal Transplant Recipients |
| title_short | Evaluating IgG Levels, Vaccination Effects, and COVID-19 Infection Severity in Renal Transplant Recipients |
| title_sort | evaluating igg levels vaccination effects and covid 19 infection severity in renal transplant recipients |
| topic | rental transplant covid-19 vaccination immunosuppression |
| url | https://qaaspa.com/index.php/bmtj/article/view/8 |
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