Effects of low molecular weight polysaccharide from Sargassum thunbergii against palmitic acid-induced intracellular lipid accumulation in 3T3-L1 adipocyte and HepG2 cells
Low molecular weight polysaccharides can be isolated from Sargassum thunbergii (LMPST) and in vitro experiments were conducted to evaluate the inhibitory effects on lipids. Two natures of LMPST were attained from S. thunbergii and appraised their LMPST on palmitic acid (PA) induced lipid accretion i...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2024-07-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2022.9250187 |
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| author | Hyo-Geun Lee D.P. Nagahawatta M.J.M.S. Kurera Kyung-Mo Song Yun-Sang Choi You-Jin Jeon Min-Cheol Kang |
| author_facet | Hyo-Geun Lee D.P. Nagahawatta M.J.M.S. Kurera Kyung-Mo Song Yun-Sang Choi You-Jin Jeon Min-Cheol Kang |
| author_sort | Hyo-Geun Lee |
| collection | DOAJ |
| description | Low molecular weight polysaccharides can be isolated from Sargassum thunbergii (LMPST) and in vitro experiments were conducted to evaluate the inhibitory effects on lipids. Two natures of LMPST were attained from S. thunbergii and appraised their LMPST on palmitic acid (PA) induced lipid accretion in HepG2, and 3T3-L1 cells. LMPST treatment lessened lipid deposition and intracellular free fatty acid and triglyceride intensities in PA-treated above mentioned cells. The mechanistic study publicized that LMPST2 significantly suppressed adipogenesis and stimulated the PA-treated 3T3-L1 cells occupied in the lipolysis pathway. Furthermore, in PA-treated HepG2 cells, the free fatty acid oxidation was significantly increased by LMPST2. Given these constructive properties of LMPST2 from S. thunbergii, is a potential candidate for diminishing the intracellular lipids, and for a therapeutic agent in those conditions. |
| format | Article |
| id | doaj-art-a5081cd2be694bc187ab7b162a4a5a3d |
| institution | Kabale University |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-a5081cd2be694bc187ab7b162a4a5a3d2025-01-10T06:56:48ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302024-07-011342244225210.26599/FSHW.2022.9250187Effects of low molecular weight polysaccharide from Sargassum thunbergii against palmitic acid-induced intracellular lipid accumulation in 3T3-L1 adipocyte and HepG2 cellsHyo-Geun Lee0D.P. Nagahawatta1M.J.M.S. Kurera2Kyung-Mo Song3Yun-Sang Choi4You-Jin Jeon5Min-Cheol Kang6Department of Marine Life Sciences, Jeju National University, Jeju 63243, Republic of KoreaDepartment of Marine Life Sciences, Jeju National University, Jeju 63243, Republic of KoreaDepartment of Marine Life Sciences, Jeju National University, Jeju 63243, Republic of KoreaResearch Group of Food Processing, Korea Food Research Institute, 245, Wanju 55365, Republic of KoreaResearch Group of Food Processing, Korea Food Research Institute, 245, Wanju 55365, Republic of KoreaDepartment of Marine Life Sciences, Jeju National University, Jeju 63243, Republic of KoreaResearch Group of Food Processing, Korea Food Research Institute, 245, Wanju 55365, Republic of KoreaLow molecular weight polysaccharides can be isolated from Sargassum thunbergii (LMPST) and in vitro experiments were conducted to evaluate the inhibitory effects on lipids. Two natures of LMPST were attained from S. thunbergii and appraised their LMPST on palmitic acid (PA) induced lipid accretion in HepG2, and 3T3-L1 cells. LMPST treatment lessened lipid deposition and intracellular free fatty acid and triglyceride intensities in PA-treated above mentioned cells. The mechanistic study publicized that LMPST2 significantly suppressed adipogenesis and stimulated the PA-treated 3T3-L1 cells occupied in the lipolysis pathway. Furthermore, in PA-treated HepG2 cells, the free fatty acid oxidation was significantly increased by LMPST2. Given these constructive properties of LMPST2 from S. thunbergii, is a potential candidate for diminishing the intracellular lipids, and for a therapeutic agent in those conditions.https://www.sciopen.com/article/10.26599/FSHW.2022.9250187sargassum thunbergiilow molecular weight polysaccharidelipid accumulationobesityliver steatosis |
| spellingShingle | Hyo-Geun Lee D.P. Nagahawatta M.J.M.S. Kurera Kyung-Mo Song Yun-Sang Choi You-Jin Jeon Min-Cheol Kang Effects of low molecular weight polysaccharide from Sargassum thunbergii against palmitic acid-induced intracellular lipid accumulation in 3T3-L1 adipocyte and HepG2 cells Food Science and Human Wellness sargassum thunbergii low molecular weight polysaccharide lipid accumulation obesity liver steatosis |
| title | Effects of low molecular weight polysaccharide from Sargassum thunbergii against palmitic acid-induced intracellular lipid accumulation in 3T3-L1 adipocyte and HepG2 cells |
| title_full | Effects of low molecular weight polysaccharide from Sargassum thunbergii against palmitic acid-induced intracellular lipid accumulation in 3T3-L1 adipocyte and HepG2 cells |
| title_fullStr | Effects of low molecular weight polysaccharide from Sargassum thunbergii against palmitic acid-induced intracellular lipid accumulation in 3T3-L1 adipocyte and HepG2 cells |
| title_full_unstemmed | Effects of low molecular weight polysaccharide from Sargassum thunbergii against palmitic acid-induced intracellular lipid accumulation in 3T3-L1 adipocyte and HepG2 cells |
| title_short | Effects of low molecular weight polysaccharide from Sargassum thunbergii against palmitic acid-induced intracellular lipid accumulation in 3T3-L1 adipocyte and HepG2 cells |
| title_sort | effects of low molecular weight polysaccharide from sargassum thunbergii against palmitic acid induced intracellular lipid accumulation in 3t3 l1 adipocyte and hepg2 cells |
| topic | sargassum thunbergii low molecular weight polysaccharide lipid accumulation obesity liver steatosis |
| url | https://www.sciopen.com/article/10.26599/FSHW.2022.9250187 |
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