Non-linear oral bioavailability and clinical pharmacokinetics of high-dose Andrographis paniculata ethanolic extract: relevant dosage implications for COVID-19 treatment

Non-linear oral bioavailability and clinical pharmacokinetics of high-dose Andrographis paniculata ethanolic extract: relevant dosage implications for COVID-19 treatment

Aim Insufficient quality control and limited dissolution of Andrographis paniculata extract capsules restricts their bioavailability and hinder the clinical use for treating mild coronavirus disease 2019 (COVID-19) patients.Objective This study aims to investigate pharmacokinetics and safety of high...

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Main Authors: Phanit Songvut, Jaratluck Akanimanee, Tawit Suriyo, Nanthanit Pholphana, Nuchanart Rangkadilok, Duangchit Panomvana, Porranee Puranajoti, Jutamaad Satayavivad
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Pharmaceutical Biology
Subjects:
Andrographis paniculata ethanolic extract
pharmacokinetics
blood chemistry
safety profiles
andrographolide
Online Access:https://www.tandfonline.com/doi/10.1080/13880209.2024.2444446
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https://www.tandfonline.com/doi/10.1080/13880209.2024.2444446

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