Proteomic and functional comparison between human induced and embryonic stem cells

Proteomic and functional comparison between human induced and embryonic stem cells

Human induced pluripotent stem cells (hiPSCs) have great potential to be used as alternatives to embryonic stem cells (hESCs) in regenerative medicine and disease modelling. In this study, we characterise the proteomes of multiple hiPSC and hESC lines derived from independent donors and find that wh...

Full description

Saved in:

Bibliographic Details
Main Authors:	Alejandro J Brenes, Eva Griesser, Linda V Sinclair, Lindsay Davidson, Alan R Prescott, Francois Singh, Elizabeth KJ Hogg, Carmen Espejo-Serrano, Hao Jiang, Harunori Yoshikawa, Melpomeni Platani, Jason R Swedlow, Greg M Findlay, Doreen A Cantrell, Angus I Lamond
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2024-11-01
Series:	eLife
Subjects:	proteomics iPSC mass spectrometry stem cell hESC protein content
Online Access:	https://elifesciences.org/articles/92025
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

TGFβ family signaling in human stem cell self-renewal and differentiation
by: Sijia Liu, et al.
Published: (2024-11-01)

Salbutamol attenuates arrhythmogenic effect of aminophylline in a hPSC-derived cardiac model
by: Daniil Kabanov, et al.
Published: (2024-11-01)

MetaboLINK is a novel algorithm for unveiling cell-specific metabolic pathways in longitudinal datasets
by: Jared Lichtarge, et al.
Published: (2025-01-01)

Generation of INS-jGCaMP7f knock-in Ca2+ reporter human embryonic stem cell line, GZLe001-C, using CRISPR/Cas9-based gene targeting
by: Xin Liu, et al.
Published: (2025-02-01)

Brain organoid models for studying the function of iPSC-derived microglia in neurodegeneration and brain tumours
by: Angelica Maria Sabogal-Guaqueta, et al.
Published: (2024-12-01)

Human induced pluripotent stem cell line (FDHSi005-A) derived from a patient with a deep intronic variant in the GNE gene
by: Kexin Jiao, et al.
Published: (2024-12-01)

Establishment of a non-integrated iPS cell line (SDQLCHi072-A) from a patient suffered from AUTS2 syndrome
by: Zilong Li, et al.
Published: (2024-12-01)

Thyroid hormone receptor beta (THRβ1) is the major regulator of T3 action in human iPSC-derived hepatocytes
by: Lorraine Soares De Oliveira, et al.
Published: (2024-12-01)

iPSC‐based modeling of THD recapitulates disease phenotypes and reveals neuronal malformation
by: Alba Tristán‐Noguero, et al.
Published: (2023-02-01)

Patient-derived induced pluripotent stem cells to study non-canonical splicing variants associated with Hypertrophic Cardiomyopathy
by: Joanna Jager, et al.
Published: (2024-12-01)

Combination of tauroursodeoxycholic acid, co-enzyme Q10 and creatine demonstrates additive neuroprotective effects in in-vitro models of Parkinson’s disease
by: Alexander Shtilbans, et al.
Published: (2024-12-01)

Generation of two induced pluripotent stem cell lines from patients with Li-Fraumeni Syndrome carrying TP53 mutation
by: Junyi Sun, et al.
Published: (2024-12-01)

NPT100-18A rescues mitochondrial oxidative stress and neuronal degeneration in human iPSC-based Parkinson’s model
by: Julian E. Alecu, et al.
Published: (2025-01-01)

The functions and applications of organoids in rheumatic immune diseases
by: Huaijuan Huang, et al.
Published: (2024-06-01)

Human CFTR deficient iPSC-macrophages reveal impaired functional and transcriptomic response upon Pseudomonas aeruginosa infection
by: Claudio Rodriguez Gonzalez, et al.
Published: (2024-11-01)

Total cell N-glycosylation is altered during differentiation of induced pluripotent stem cells to neural stem cells and is disturbed by trisomy 21
by: Ana Cindrić, et al.
Published: (2025-01-01)

Generation of four human-derived iPSC TorsinA-3xFLAG reporter lines from a DYT-TOR1A patient
by: Kerstin Tanzer, et al.
Published: (2024-12-01)

Generation of CRISPR/Cas9-edited human iPSC lines carrying homozygous and heterozygous SAMD9 p.I983S mutations
by: Majd Khiami, et al.
Published: (2024-12-01)

Mechanistic elucidation of human pancreatic acinar development using single-cell transcriptome analysis on a human iPSC differentiation model
by: Atsushi Mima, et al.
Published: (2025-02-01)

Advances in Induced Pluripotent Stem Cell-Derived Natural Killer Cell Therapy
by: Wenhua Qiao, et al.
Published: (2024-11-01)

Optimized Method to Generate Well-Characterized Macrophages from Induced Pluripotent Stem Cells
by: Qimin Hai, et al.
Published: (2025-01-01)

Human-induced pluripotent stem cell-derived microglia integrate into mouse retina and recapitulate features of endogenous microglia
by: Wenxin Ma, et al.
Published: (2024-11-01)

Real-Time Implementation of a Hybrid ESC Approach for Maximising the Extracted Photovoltaic Power Under Partial Shading Conditions
by: Menadi Abdelkrim, et al.
Published: (2024-01-01)

Direct effects of prolonged TNF-α and IL-6 exposure on neural activity in human iPSC-derived neuron-astrocyte co-cultures
by: Noah Goshi, et al.
Published: (2025-02-01)

Matrix-free human lung organoids derived from induced pluripotent stem cells to model lung injury
by: Bettina Budeus, et al.
Published: (2024-12-01)

In vitro vascular differentiation system efficiently produces natural killer cells for cancer immunotherapies
by: Yekaterina Galat, et al.
Published: (2023-12-01)

Unbiased identification of cell identity in dense mixed neural cultures
by: Sarah De Beuckeleer, et al.
Published: (2025-01-01)

Integrating melt electrospinning writing and microfluidics to engineer a human cardiac microenvironment for high-fidelity drug screening
by: Yu-hong Wang, et al.
Published: (2025-03-01)

Symmetric Dimethylarginine Predicts Previously Undetected Atrial Fibrillation in Patients With Ischemic Stroke
by: Juliane Hannemann, et al.
Published: (2024-09-01)

Development of a Novel Microphysiological System for Peripheral Neurotoxicity Prediction Using Human iPSC-Derived Neurons with Morphological Deep Learning
by: Xiaobo Han, et al.
Published: (2024-11-01)

Advances in understanding the regulation of pluripotency fate transition in embryonic stem cells
by: Yong kang Jia, et al.
Published: (2024-10-01)

Corrigendum: Advances in understanding the regulation of pluripotency fate transition in embryonic stem cells
by: Yong kang Jia, et al.
Published: (2024-11-01)

Combining the induced pluripotent stem cell (iPSC) technology with chimeric antigen receptor (CAR)-based immunotherapy: recent advances, challenges, and future prospects
by: Mehdi Alidadi, et al.
Published: (2024-11-01)

Editorial: Animal models of Alzheimer's disease and other dementias: past, present, and future
by: Ines Moreno-Gonzalez, et al.
Published: (2025-01-01)

Comparative analysis of regulations and studies on stem cell therapies: focusing on induced pluripotent stem cell (iPSC)-based treatments
by: Seohyun Jennie Song, et al.
Published: (2024-11-01)

Homozygous variant in translocase of outer mitochondrial membrane 7 leads to metabolic reprogramming and microcephalic osteodysplastic dwarfism with moyamoya diseaseResearch in context
by: Chia-Yi Li, et al.
Published: (2024-12-01)

Revolutionizing medicine practice using stem cells in healthcare: review article
by: Prajnashree Acharya, et al.
Published: (2024-07-01)

Antibody-mediated degradation of 4R-tau restores mitochondrial membrane polarization in human induced pluripotent stem cell-derived neurons with the MAPT 10+16 mutation
by: Dale O. Starkie, et al.
Published: (2024-12-01)

Single-cell RNA sequencing reveals key regulators and differentiation trajectory of iPSC-derived cardiomyocytes
by: Lu Li, et al.
Published: (2024-11-01)

High levels of histone acetylation modifications promote the formation of PGCs
by: Ziduo Zhao, et al.
Published: (2025-02-01)