A Flavonoid Glycoside Compound from <em>Siraitia grosvenorii</em> with Anti-Inflammatory and Hepatoprotective Effects In Vitro
Inflammation is a pivotal factor in the development and advancement of conditions like NAFLD and asthma. Diet can affect several phases of inflammation and significantly influence multiple inflammatory disorders. <i>Siraitia grosvenorii</i>, a traditional Chinese edible and medicinal pla...
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2024-04-01
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| author | Juanjiang Wu Huaxue Huang Limin Gong Xing Tian Zhi Peng Yizhun Zhu Wei Wang |
| author_facet | Juanjiang Wu Huaxue Huang Limin Gong Xing Tian Zhi Peng Yizhun Zhu Wei Wang |
| author_sort | Juanjiang Wu |
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| description | Inflammation is a pivotal factor in the development and advancement of conditions like NAFLD and asthma. Diet can affect several phases of inflammation and significantly influence multiple inflammatory disorders. <i>Siraitia grosvenorii</i>, a traditional Chinese edible and medicinal plant, is considered beneficial to health. Flavonoids can suppress inflammatory cytokines, which play a crucial role in regulating inflammation. In the present experiments, kaempferol 3-<i>O</i>-<i>α</i>-L-rhamnoside-7-<i>O</i>-<i>β</i>-D-xylosyl(1→2)-<i>O</i>-<i>α</i>-L-rhamnoside (SGPF) is a flavonoid glycoside that was first isolated from <i>S</i>. <i>grosvenorii</i>. A series of experimental investigations were carried out to investigate whether the flavonoid component has anti-inflammatory and hepatoprotective effects in this plant. The researchers showed that SGPF has a stronger modulation of protein expression in LPS-induced macrophages (MH-S) and OA-induced HepG2 cells. The drug was dose-dependent on cells, and in the TLR4/NF-κB/MyD88 pathway and Nrf2/HO-1 pathway, SGPF regulated all protein expression. SGPF has a clear anti-inflammatory and hepatoprotective function in inflammatory conditions. |
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| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-04-01 |
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| series | Biomolecules |
| spelling | doaj-art-a4da6ed6051d4a57a7f6008f92ddbdba2024-12-17T09:33:27ZengMDPI AGBiomolecules2218-273X2024-04-0114445010.3390/biom14040450A Flavonoid Glycoside Compound from <em>Siraitia grosvenorii</em> with Anti-Inflammatory and Hepatoprotective Effects In VitroJuanjiang Wu0Huaxue Huang1Limin Gong2Xing Tian3Zhi Peng4Yizhun Zhu5Wei Wang6Faculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, ChinaFaculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, ChinaFaculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, ChinaFaculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, ChinaHunan Huacheng Biotech, Inc., High-Tech Zone, Changsha 410205, ChinaFaculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, ChinaFaculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, ChinaInflammation is a pivotal factor in the development and advancement of conditions like NAFLD and asthma. Diet can affect several phases of inflammation and significantly influence multiple inflammatory disorders. <i>Siraitia grosvenorii</i>, a traditional Chinese edible and medicinal plant, is considered beneficial to health. Flavonoids can suppress inflammatory cytokines, which play a crucial role in regulating inflammation. In the present experiments, kaempferol 3-<i>O</i>-<i>α</i>-L-rhamnoside-7-<i>O</i>-<i>β</i>-D-xylosyl(1→2)-<i>O</i>-<i>α</i>-L-rhamnoside (SGPF) is a flavonoid glycoside that was first isolated from <i>S</i>. <i>grosvenorii</i>. A series of experimental investigations were carried out to investigate whether the flavonoid component has anti-inflammatory and hepatoprotective effects in this plant. The researchers showed that SGPF has a stronger modulation of protein expression in LPS-induced macrophages (MH-S) and OA-induced HepG2 cells. The drug was dose-dependent on cells, and in the TLR4/NF-κB/MyD88 pathway and Nrf2/HO-1 pathway, SGPF regulated all protein expression. SGPF has a clear anti-inflammatory and hepatoprotective function in inflammatory conditions.https://www.mdpi.com/2218-273X/14/4/450<i>Siraitia grosvenorii</i>flavonoid glycosideanti-inflammatoryhepatoprotective |
| spellingShingle | Juanjiang Wu Huaxue Huang Limin Gong Xing Tian Zhi Peng Yizhun Zhu Wei Wang A Flavonoid Glycoside Compound from <em>Siraitia grosvenorii</em> with Anti-Inflammatory and Hepatoprotective Effects In Vitro Biomolecules <i>Siraitia grosvenorii</i> flavonoid glycoside anti-inflammatory hepatoprotective |
| title | A Flavonoid Glycoside Compound from <em>Siraitia grosvenorii</em> with Anti-Inflammatory and Hepatoprotective Effects In Vitro |
| title_full | A Flavonoid Glycoside Compound from <em>Siraitia grosvenorii</em> with Anti-Inflammatory and Hepatoprotective Effects In Vitro |
| title_fullStr | A Flavonoid Glycoside Compound from <em>Siraitia grosvenorii</em> with Anti-Inflammatory and Hepatoprotective Effects In Vitro |
| title_full_unstemmed | A Flavonoid Glycoside Compound from <em>Siraitia grosvenorii</em> with Anti-Inflammatory and Hepatoprotective Effects In Vitro |
| title_short | A Flavonoid Glycoside Compound from <em>Siraitia grosvenorii</em> with Anti-Inflammatory and Hepatoprotective Effects In Vitro |
| title_sort | flavonoid glycoside compound from em siraitia grosvenorii em with anti inflammatory and hepatoprotective effects in vitro |
| topic | <i>Siraitia grosvenorii</i> flavonoid glycoside anti-inflammatory hepatoprotective |
| url | https://www.mdpi.com/2218-273X/14/4/450 |
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