A Flavonoid Glycoside Compound from <em>Siraitia grosvenorii</em> with Anti-Inflammatory and Hepatoprotective Effects In Vitro
Inflammation is a pivotal factor in the development and advancement of conditions like NAFLD and asthma. Diet can affect several phases of inflammation and significantly influence multiple inflammatory disorders. <i>Siraitia grosvenorii</i>, a traditional Chinese edible and medicinal pla...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-04-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/14/4/450 |
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| Summary: | Inflammation is a pivotal factor in the development and advancement of conditions like NAFLD and asthma. Diet can affect several phases of inflammation and significantly influence multiple inflammatory disorders. <i>Siraitia grosvenorii</i>, a traditional Chinese edible and medicinal plant, is considered beneficial to health. Flavonoids can suppress inflammatory cytokines, which play a crucial role in regulating inflammation. In the present experiments, kaempferol 3-<i>O</i>-<i>α</i>-L-rhamnoside-7-<i>O</i>-<i>β</i>-D-xylosyl(1→2)-<i>O</i>-<i>α</i>-L-rhamnoside (SGPF) is a flavonoid glycoside that was first isolated from <i>S</i>. <i>grosvenorii</i>. A series of experimental investigations were carried out to investigate whether the flavonoid component has anti-inflammatory and hepatoprotective effects in this plant. The researchers showed that SGPF has a stronger modulation of protein expression in LPS-induced macrophages (MH-S) and OA-induced HepG2 cells. The drug was dose-dependent on cells, and in the TLR4/NF-κB/MyD88 pathway and Nrf2/HO-1 pathway, SGPF regulated all protein expression. SGPF has a clear anti-inflammatory and hepatoprotective function in inflammatory conditions. |
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| ISSN: | 2218-273X |