Col1A1 as a new decoder of clinical features and immune microenvironment in ovarian cancer
BackgroundsCollagen type I alpha 1 chain (COL1A1) is a key protein encoding fibrillar collagen, playing a crucial role in the tumor microenvironment (TME) due to its complex functions and close association with tumor invasiveness. This has made COL1A1 a focal point in cancer biology research. Howeve...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1496090/full |
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| author | Xiao Xiao Fangyi Long Shaolan Yu Wengjuan Wu Dayan Nie Xiaoyan Ren Wen Li Xujuan Wang Ling Yu Pinghan Wang Gang Wang |
| author_facet | Xiao Xiao Fangyi Long Shaolan Yu Wengjuan Wu Dayan Nie Xiaoyan Ren Wen Li Xujuan Wang Ling Yu Pinghan Wang Gang Wang |
| author_sort | Xiao Xiao |
| collection | DOAJ |
| description | BackgroundsCollagen type I alpha 1 chain (COL1A1) is a key protein encoding fibrillar collagen, playing a crucial role in the tumor microenvironment (TME) due to its complex functions and close association with tumor invasiveness. This has made COL1A1 a focal point in cancer biology research. However, studies investigating the relationship between COL1A1 expression levels and clinical characteristics of ovarian cancer (OC) remain limited.MethodsThis study integrated resources from publicly available online databases and immunohistochemistry (IHC) techniques to analyze and validate COL1A1 expression in OC tissues, and evaluated its potential association with clinical features in OC patients. The prognostic value of COL1A1 was assessed using Kaplan-Meier (KM) survival curve analysis. The TIMER and TISIDB databases to explore the potential relationship between COL1A1 expression and immune microenvironment in OC tissues. The LinkedOmics and INPUT2 databases were used to analyze differential gene expression in OC, This was followed by enrichment analysis using the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) annotations to identify and predict potential signaling pathways associated with COL1A1.ResultsOur study demonstrated that COL1A1 expression was significantly elevated in OC tissues compared to normal ovarian tissues. This elevated expression was closely associated with tumor metastasis, poor prognosis, and advanced pathological stages in OC patients. Moreover, COL1A1 expression showed a significant correlation with immune cell infiltration and the expression of immune-related genes within the TME.Further analyses revealed that COL1A1 and its co-expressed genes were primarily enriched in key signaling pathways involved in OC invasion, metastasis, and angiogenesis, indicating its potential role in driving OC progression.ConclusionsOur study found that upregulation of COL1A1 expression is significantly associated with lymph node metastasis of OC and can affect the immune microenvironment. Based on this, COL1A1 could serve as a promising biomarker for OC prognosis and provide a new perspective for the development of potential immunotherapies for patients with OC. |
| format | Article |
| id | doaj-art-a4d141cba1c845ed9ba8be5d1aeb5c98 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-a4d141cba1c845ed9ba8be5d1aeb5c982025-01-08T06:11:50ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.14960901496090Col1A1 as a new decoder of clinical features and immune microenvironment in ovarian cancerXiao Xiao0Fangyi Long1Shaolan Yu2Wengjuan Wu3Dayan Nie4Xiaoyan Ren5Wen Li6Xujuan Wang7Ling Yu8Pinghan Wang9Gang Wang10Department of Gynecology, Sichuan Provincial Women’s and Children’s Hospital, The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaLaboratory Medicine Center, Sichuan Provincial Women’s and Children’s Hospital, The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaLaboratory Medicine Center, Sichuan Provincial Women’s and Children’s Hospital, The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaDepartment of Gynecology, Sichuan Provincial Women’s and Children’s Hospital, The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaLaboratory Medicine Center, Sichuan Provincial Women’s and Children’s Hospital, The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaSchool of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan, ChinaSchool of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan, ChinaSchool of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan, ChinaLaboratory Medicine Center, Sichuan Provincial Women’s and Children’s Hospital, The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaLaboratory Medicine Center, Sichuan Provincial Women’s and Children’s Hospital, The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaDepartment of Gynecology, Sichuan Provincial Women’s and Children’s Hospital, The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaBackgroundsCollagen type I alpha 1 chain (COL1A1) is a key protein encoding fibrillar collagen, playing a crucial role in the tumor microenvironment (TME) due to its complex functions and close association with tumor invasiveness. This has made COL1A1 a focal point in cancer biology research. However, studies investigating the relationship between COL1A1 expression levels and clinical characteristics of ovarian cancer (OC) remain limited.MethodsThis study integrated resources from publicly available online databases and immunohistochemistry (IHC) techniques to analyze and validate COL1A1 expression in OC tissues, and evaluated its potential association with clinical features in OC patients. The prognostic value of COL1A1 was assessed using Kaplan-Meier (KM) survival curve analysis. The TIMER and TISIDB databases to explore the potential relationship between COL1A1 expression and immune microenvironment in OC tissues. The LinkedOmics and INPUT2 databases were used to analyze differential gene expression in OC, This was followed by enrichment analysis using the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) annotations to identify and predict potential signaling pathways associated with COL1A1.ResultsOur study demonstrated that COL1A1 expression was significantly elevated in OC tissues compared to normal ovarian tissues. This elevated expression was closely associated with tumor metastasis, poor prognosis, and advanced pathological stages in OC patients. Moreover, COL1A1 expression showed a significant correlation with immune cell infiltration and the expression of immune-related genes within the TME.Further analyses revealed that COL1A1 and its co-expressed genes were primarily enriched in key signaling pathways involved in OC invasion, metastasis, and angiogenesis, indicating its potential role in driving OC progression.ConclusionsOur study found that upregulation of COL1A1 expression is significantly associated with lymph node metastasis of OC and can affect the immune microenvironment. Based on this, COL1A1 could serve as a promising biomarker for OC prognosis and provide a new perspective for the development of potential immunotherapies for patients with OC.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1496090/fullCOL1A1ovarian cancer (OC)immune infiltrationbiomarkerprognosistumor microenvironment |
| spellingShingle | Xiao Xiao Fangyi Long Shaolan Yu Wengjuan Wu Dayan Nie Xiaoyan Ren Wen Li Xujuan Wang Ling Yu Pinghan Wang Gang Wang Col1A1 as a new decoder of clinical features and immune microenvironment in ovarian cancer Frontiers in Immunology COL1A1 ovarian cancer (OC) immune infiltration biomarker prognosis tumor microenvironment |
| title | Col1A1 as a new decoder of clinical features and immune microenvironment in ovarian cancer |
| title_full | Col1A1 as a new decoder of clinical features and immune microenvironment in ovarian cancer |
| title_fullStr | Col1A1 as a new decoder of clinical features and immune microenvironment in ovarian cancer |
| title_full_unstemmed | Col1A1 as a new decoder of clinical features and immune microenvironment in ovarian cancer |
| title_short | Col1A1 as a new decoder of clinical features and immune microenvironment in ovarian cancer |
| title_sort | col1a1 as a new decoder of clinical features and immune microenvironment in ovarian cancer |
| topic | COL1A1 ovarian cancer (OC) immune infiltration biomarker prognosis tumor microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1496090/full |
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