Helicobacter pylori and cardiovascular complications: a mechanism based review on role of Helicobacter pylori in cardiovascular diseases
Heart disease comprises a wide class of cardiovascular abnormalities, including ischemic heart disease, myocardial infarction, atherosclerosis, and coronary artery disease. It is the leading cause of death all over the world. Several traditional and novel risk factors, such as infectious and noninfe...
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| Language: | English |
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Elsevier
2016-12-01
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| Series: | Integrative Medicine Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221342201630035X |
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| author | Prasad G. Jamkhande Surendra G. Gattani Shaikh Ayesha Farhat |
| author_facet | Prasad G. Jamkhande Surendra G. Gattani Shaikh Ayesha Farhat |
| author_sort | Prasad G. Jamkhande |
| collection | DOAJ |
| description | Heart disease comprises a wide class of cardiovascular abnormalities, including ischemic heart disease, myocardial infarction, atherosclerosis, and coronary artery disease. It is the leading cause of death all over the world. Several traditional and novel risk factors, such as infectious and noninfectious agents, have been associated with heart disease. Out of these, Helicobacter pylori has been recently introduced as an important etiological factor for heart disease. Numerous seroepidemiological findings observed H. pylori antibodies in the blood of a patient with cardiovascular complications. The bacteria survive in the epithelial cells of gastric organs and cause digestive complications. Excess inflammatory pathogenesis and prognosis stimulate an immune response that further causes significant disturbances in various factors like cytokines, fibrinogen, triglycerides, high density lipoprotein, C-reactive protein, heat shock protein, and white blood cell count, and provoke a number of problems such as atherosclerosis and prothrombic state, and cross-reactivity which eventually leads to heart diseases. H. pylori releases toxigenic nutrients, chiefly vacuolating cytotoxin gen A (Vac A) and cytotoxin associated gene A (Cag A), of which Cag A is more virulent and involved in the formation of cholesterol patches in arteries, induction of autoimmune disorder, and release of immune mediated response. Although numerous mechanisms have been correlated with H. pylori and heart disease, the exact role of bacteria is still ambiguous. |
| format | Article |
| id | doaj-art-a4b5bdc276134242bd0f83c2d329a43f |
| institution | Kabale University |
| issn | 2213-4220 |
| language | English |
| publishDate | 2016-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Integrative Medicine Research |
| spelling | doaj-art-a4b5bdc276134242bd0f83c2d329a43f2025-08-20T03:49:08ZengElsevierIntegrative Medicine Research2213-42202016-12-015424424910.1016/j.imr.2016.05.005Helicobacter pylori and cardiovascular complications: a mechanism based review on role of Helicobacter pylori in cardiovascular diseasesPrasad G. JamkhandeSurendra G. GattaniShaikh Ayesha FarhatHeart disease comprises a wide class of cardiovascular abnormalities, including ischemic heart disease, myocardial infarction, atherosclerosis, and coronary artery disease. It is the leading cause of death all over the world. Several traditional and novel risk factors, such as infectious and noninfectious agents, have been associated with heart disease. Out of these, Helicobacter pylori has been recently introduced as an important etiological factor for heart disease. Numerous seroepidemiological findings observed H. pylori antibodies in the blood of a patient with cardiovascular complications. The bacteria survive in the epithelial cells of gastric organs and cause digestive complications. Excess inflammatory pathogenesis and prognosis stimulate an immune response that further causes significant disturbances in various factors like cytokines, fibrinogen, triglycerides, high density lipoprotein, C-reactive protein, heat shock protein, and white blood cell count, and provoke a number of problems such as atherosclerosis and prothrombic state, and cross-reactivity which eventually leads to heart diseases. H. pylori releases toxigenic nutrients, chiefly vacuolating cytotoxin gen A (Vac A) and cytotoxin associated gene A (Cag A), of which Cag A is more virulent and involved in the formation of cholesterol patches in arteries, induction of autoimmune disorder, and release of immune mediated response. Although numerous mechanisms have been correlated with H. pylori and heart disease, the exact role of bacteria is still ambiguous.http://www.sciencedirect.com/science/article/pii/S221342201630035Xatherosclerosiscardiovascular diseasesheat shock proteinHelicobacter pyloritumor necrosis factor |
| spellingShingle | Prasad G. Jamkhande Surendra G. Gattani Shaikh Ayesha Farhat Helicobacter pylori and cardiovascular complications: a mechanism based review on role of Helicobacter pylori in cardiovascular diseases Integrative Medicine Research atherosclerosis cardiovascular diseases heat shock protein Helicobacter pylori tumor necrosis factor |
| title | Helicobacter pylori and cardiovascular complications: a mechanism based review on role of Helicobacter pylori in cardiovascular diseases |
| title_full | Helicobacter pylori and cardiovascular complications: a mechanism based review on role of Helicobacter pylori in cardiovascular diseases |
| title_fullStr | Helicobacter pylori and cardiovascular complications: a mechanism based review on role of Helicobacter pylori in cardiovascular diseases |
| title_full_unstemmed | Helicobacter pylori and cardiovascular complications: a mechanism based review on role of Helicobacter pylori in cardiovascular diseases |
| title_short | Helicobacter pylori and cardiovascular complications: a mechanism based review on role of Helicobacter pylori in cardiovascular diseases |
| title_sort | helicobacter pylori and cardiovascular complications a mechanism based review on role of helicobacter pylori in cardiovascular diseases |
| topic | atherosclerosis cardiovascular diseases heat shock protein Helicobacter pylori tumor necrosis factor |
| url | http://www.sciencedirect.com/science/article/pii/S221342201630035X |
| work_keys_str_mv | AT prasadgjamkhande helicobacterpyloriandcardiovascularcomplicationsamechanismbasedreviewonroleofhelicobacterpyloriincardiovasculardiseases AT surendraggattani helicobacterpyloriandcardiovascularcomplicationsamechanismbasedreviewonroleofhelicobacterpyloriincardiovasculardiseases AT shaikhayeshafarhat helicobacterpyloriandcardiovascularcomplicationsamechanismbasedreviewonroleofhelicobacterpyloriincardiovasculardiseases |