Comparative evaluation of glucose transporter 1 expression in oral squamous cell carcinoma with and without cervical lymph node metastasis
Background. In addition to the local resection of the primary tumor, metastatic oral squamous cell carcinoma (OSCC) patients require neck lymph node resection. In these patients, it is quite difficult to accurately determine whether they have metastases or not, which may lead to excessive medical tr...
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Tabriz University of Medical Sciences
2025-04-01
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| Series: | مجله پزشکی دانشگاه علوم پزشکی تبریز |
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| Online Access: | https://mj.tbzmed.ac.ir/PDF/mj-47-29.pdf |
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| author | Saeedeh Khalesi Laleh Maleki Parnia Mirzaee |
| author_facet | Saeedeh Khalesi Laleh Maleki Parnia Mirzaee |
| author_sort | Saeedeh Khalesi |
| collection | DOAJ |
| description | Background. In addition to the local resection of the primary tumor, metastatic oral squamous cell carcinoma (OSCC) patients require neck lymph node resection. In these patients, it is quite difficult to accurately determine whether they have metastases or not, which may lead to excessive medical treatment or insufficient treatment. Therefore, finding molecular markers associated with metastasis with high accuracy and sensitivity is a top priority in OSCC research. Therefore, this study aimed to compare the level of glucose transporter 1 (GLUT1) expression in OSCC with and without metastasis to cervical lymph nodes. Methods. In this descriptive-analytical cross-sectional study, 20 OSCC samples without cervical lymph node metastasis and 20 OSCC samples with cervical lymph node metastasis from the cases registered in the archives of the Pathology Department of Ayatollah Kashani Hospital, Isfahan, which were prepared by excisional biopsies, were selected for investigation. The samples were stained using the immunohistochemistry method for GLUT1 and then simultaneously examined by two oral pathologists. All data were analyzed by Mann-Whitney and Kruskal-Wallis tests, and P < 0.05 was considered statistically significant. Results. The statistical analysis of the obtained data demonstrated that the mean expression of GLUT1 in the studied OSCC tissues had no statistical difference in terms of age, gender, lesion location, disease stage, or histopathological grade (P < 0.05). The results revealed that although the level of GLUT1 expression in non-metastatic OSCC was higher than that in OSCC with metastasis to cervical lymph nodes, this difference was not statistically significant (P = 0.841). Conclusion. GLUT1 expression is probably not a predictor of cervical lymph node involvement in OSCC. Practical Implications. The expression level of GLUT1 is not related to the prognosis of patients with OSCC. |
| format | Article |
| id | doaj-art-a4b1da9ae4cb486c91b4b5112b0802c8 |
| institution | OA Journals |
| issn | 2783-2031 2783-204X |
| language | fas |
| publishDate | 2025-04-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | مجله پزشکی دانشگاه علوم پزشکی تبریز |
| spelling | doaj-art-a4b1da9ae4cb486c91b4b5112b0802c82025-08-20T02:30:23ZfasTabriz University of Medical Sciencesمجله پزشکی دانشگاه علوم پزشکی تبریز2783-20312783-204X2025-04-01471294010.34172/mj.025.33481mj-33481Comparative evaluation of glucose transporter 1 expression in oral squamous cell carcinoma with and without cervical lymph node metastasisSaeedeh Khalesi0Laleh Maleki1Parnia Mirzaee2Dental Materials Research Center, Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Isfahan University of Medical Sciences, Isfahan, IranDental Research Center, Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Isfahan University of Medical Sciences, Isfahan, IranGeneral Doctoral Student, Faculty of Dentistry, Isfahan University of Medical Sciences, Isfahan, IranBackground. In addition to the local resection of the primary tumor, metastatic oral squamous cell carcinoma (OSCC) patients require neck lymph node resection. In these patients, it is quite difficult to accurately determine whether they have metastases or not, which may lead to excessive medical treatment or insufficient treatment. Therefore, finding molecular markers associated with metastasis with high accuracy and sensitivity is a top priority in OSCC research. Therefore, this study aimed to compare the level of glucose transporter 1 (GLUT1) expression in OSCC with and without metastasis to cervical lymph nodes. Methods. In this descriptive-analytical cross-sectional study, 20 OSCC samples without cervical lymph node metastasis and 20 OSCC samples with cervical lymph node metastasis from the cases registered in the archives of the Pathology Department of Ayatollah Kashani Hospital, Isfahan, which were prepared by excisional biopsies, were selected for investigation. The samples were stained using the immunohistochemistry method for GLUT1 and then simultaneously examined by two oral pathologists. All data were analyzed by Mann-Whitney and Kruskal-Wallis tests, and P < 0.05 was considered statistically significant. Results. The statistical analysis of the obtained data demonstrated that the mean expression of GLUT1 in the studied OSCC tissues had no statistical difference in terms of age, gender, lesion location, disease stage, or histopathological grade (P < 0.05). The results revealed that although the level of GLUT1 expression in non-metastatic OSCC was higher than that in OSCC with metastasis to cervical lymph nodes, this difference was not statistically significant (P = 0.841). Conclusion. GLUT1 expression is probably not a predictor of cervical lymph node involvement in OSCC. Practical Implications. The expression level of GLUT1 is not related to the prognosis of patients with OSCC.https://mj.tbzmed.ac.ir/PDF/mj-47-29.pdfneoplasmmetastasisglut1squamous cell carcinomaoral |
| spellingShingle | Saeedeh Khalesi Laleh Maleki Parnia Mirzaee Comparative evaluation of glucose transporter 1 expression in oral squamous cell carcinoma with and without cervical lymph node metastasis مجله پزشکی دانشگاه علوم پزشکی تبریز neoplasm metastasis glut1 squamous cell carcinoma oral |
| title | Comparative evaluation of glucose transporter 1 expression in oral squamous cell carcinoma with and without cervical lymph node metastasis |
| title_full | Comparative evaluation of glucose transporter 1 expression in oral squamous cell carcinoma with and without cervical lymph node metastasis |
| title_fullStr | Comparative evaluation of glucose transporter 1 expression in oral squamous cell carcinoma with and without cervical lymph node metastasis |
| title_full_unstemmed | Comparative evaluation of glucose transporter 1 expression in oral squamous cell carcinoma with and without cervical lymph node metastasis |
| title_short | Comparative evaluation of glucose transporter 1 expression in oral squamous cell carcinoma with and without cervical lymph node metastasis |
| title_sort | comparative evaluation of glucose transporter 1 expression in oral squamous cell carcinoma with and without cervical lymph node metastasis |
| topic | neoplasm metastasis glut1 squamous cell carcinoma oral |
| url | https://mj.tbzmed.ac.ir/PDF/mj-47-29.pdf |
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