Exosomes derived from platelet-rich plasma present a novel potential in repairing knee articular cartilage defect combined with cyclic peptide-modified β-TCP scaffold

Exosomes derived from platelet-rich plasma present a novel potential in repairing knee articular cartilage defect combined with cyclic peptide-modified β-TCP scaffold

Abstract Background The aim of this study was to investigate the therapeutic effects and mechanisms of PRP-exos combined with cyclic peptide-modified β-TCP scaffold in the treatment of rabbit knee cartilage defect. Methods PRP-exos were extracted and characterized by TEM, NTA and WB. The therapeutic...

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Bibliographic Details
Main Authors: Xuchang Liu, Rudong Chen, Guanzheng Cui, Rongjie Feng, Kechun Liu
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
PRP-exos
Cyclic peptide
β-TCP scaffold
Cartilage defect
PI3K/AKT signaling pathway
Online Access:https://doi.org/10.1186/s13018-024-05202-z
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