Effectiveness of home or hospital initiation of treatment at diagnosis for children with type 1 diabetes (DECIDE trial): a multicentre individually randomised controlled trial
Objective To determine whether, in children with newly diagnosed type 1 diabetes who were not acutely unwell, management at home for initiation of insulin treatment and education of the child and family, would result in improved clinical and psychological outcomes at 2 years postdiagnosis.Design A m...
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BMJ Publishing Group
2019-12-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/9/12/e032317.full |
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| author | Mirella Longo Tabitha Randell Justin Davies Morro Touray John W Gregory David Cohen Nicola Trevelyan Nicola Harman Timothy Pickles Julia Townson Sue Channon Rebecca Playle Michael Robling Justin Warner Lesley Lowes |
| author_facet | Mirella Longo Tabitha Randell Justin Davies Morro Touray John W Gregory David Cohen Nicola Trevelyan Nicola Harman Timothy Pickles Julia Townson Sue Channon Rebecca Playle Michael Robling Justin Warner Lesley Lowes |
| author_sort | Mirella Longo |
| collection | DOAJ |
| description | Objective To determine whether, in children with newly diagnosed type 1 diabetes who were not acutely unwell, management at home for initiation of insulin treatment and education of the child and family, would result in improved clinical and psychological outcomes at 2 years postdiagnosis.Design A multicentre randomised controlled trial (January 2008/October 2013).Setting Eight paediatric diabetes centres in England, Wales and Northern Ireland.Participants 203 clinically well children aged under 17 years, with newly diagnosed type 1 diabetes and their carers.Intervention Management of the initiation period from diagnosis at home, for a minimum of 3 days, to include at least six supervised injections and delivery of pragmatic educational care.Main outcome measures Primary outcome was glycosylated haemoglobin (HbA1c) concentration at 24 months postdiagnosis. Secondary outcomes included coping, anxiety, quality of life and use of NHS resources.Results 203 children, newly diagnosed, were randomised to commence management at home (n=101) or in hospital (n=102). At the 24 month primary end point, there was one withdrawal and a follow-up rate of 194/202 (96%). Mean HbA1c in the home treatment arm was 72.1 mmol/mol and in the hospital treated arm 72.6 mmol/mol. There was a negligible difference between the mean HbA1c levels in the two arms adjusted for baseline (1.01, 95% CI 0.93 to 1.09). There were mostly no differences in secondary outcomes at 24 months, apart from better child self-esteem in the home-arm. No home-arm children were admitted to hospital during initiation and there were no adverse events at that time. The number of investigations was higher in hospital patients during the follow-up period. There were no differences in insulin regimens between the two arms.Conclusions There is no evidence of a difference between home-based and hospital-based initiation of care in children newly diagnosed with type 1 diabetes across relevant outcomes.Trial registration number ISRCTN78114042. |
| format | Article |
| id | doaj-art-a44a43e26df244ffbda4854c8a4b9c96 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-a44a43e26df244ffbda4854c8a4b9c962024-12-03T19:00:08ZengBMJ Publishing GroupBMJ Open2044-60552019-12-0191210.1136/bmjopen-2019-032317Effectiveness of home or hospital initiation of treatment at diagnosis for children with type 1 diabetes (DECIDE trial): a multicentre individually randomised controlled trialMirella Longo0Tabitha Randell1Justin Davies2Morro Touray3John W Gregory4David Cohen5Nicola Trevelyan6Nicola Harman7Timothy Pickles8Julia Townson9Sue Channon10Rebecca Playle11Michael Robling12Justin Warner13Lesley Lowes144Cardiff University, UKNottingham Children`s Hospital, Nottingham, UKFaculty of Medicine, Imperial College London, London, UKDepartment of Health Economics, University of Surrey, Guildford, UK5 Division of Population Health, School of Medicine, Cardiff University, Cardiff, UKNorthwick Park, London North West University Healthcare NHS Trust, Harrow, UKPaediatric Diabetes, Southampton Children`s Hospital, Southampton, UK6 University of Liverpool, Institute of Translational Medicine, Liverpool, UKCentre for Trials Research, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK2 Centre for Trials Research, Cardiff University, Cardiff, UKCentre for Trials Research, Cardiff University, Cardiff, UKCentre for Trials Research, Cardiff University, Cardiff, South Glamorgan, UKCentre for Trials Research, Cardiff University, Cardiff, UK9 Department of Child Health, Cardiff and Vale University Health Board, Cardiff, UK10 School of Healthcare Sciences, Cardiff University, Cardiff, UKObjective To determine whether, in children with newly diagnosed type 1 diabetes who were not acutely unwell, management at home for initiation of insulin treatment and education of the child and family, would result in improved clinical and psychological outcomes at 2 years postdiagnosis.Design A multicentre randomised controlled trial (January 2008/October 2013).Setting Eight paediatric diabetes centres in England, Wales and Northern Ireland.Participants 203 clinically well children aged under 17 years, with newly diagnosed type 1 diabetes and their carers.Intervention Management of the initiation period from diagnosis at home, for a minimum of 3 days, to include at least six supervised injections and delivery of pragmatic educational care.Main outcome measures Primary outcome was glycosylated haemoglobin (HbA1c) concentration at 24 months postdiagnosis. Secondary outcomes included coping, anxiety, quality of life and use of NHS resources.Results 203 children, newly diagnosed, were randomised to commence management at home (n=101) or in hospital (n=102). At the 24 month primary end point, there was one withdrawal and a follow-up rate of 194/202 (96%). Mean HbA1c in the home treatment arm was 72.1 mmol/mol and in the hospital treated arm 72.6 mmol/mol. There was a negligible difference between the mean HbA1c levels in the two arms adjusted for baseline (1.01, 95% CI 0.93 to 1.09). There were mostly no differences in secondary outcomes at 24 months, apart from better child self-esteem in the home-arm. No home-arm children were admitted to hospital during initiation and there were no adverse events at that time. The number of investigations was higher in hospital patients during the follow-up period. There were no differences in insulin regimens between the two arms.Conclusions There is no evidence of a difference between home-based and hospital-based initiation of care in children newly diagnosed with type 1 diabetes across relevant outcomes.Trial registration number ISRCTN78114042.https://bmjopen.bmj.com/content/9/12/e032317.full |
| spellingShingle | Mirella Longo Tabitha Randell Justin Davies Morro Touray John W Gregory David Cohen Nicola Trevelyan Nicola Harman Timothy Pickles Julia Townson Sue Channon Rebecca Playle Michael Robling Justin Warner Lesley Lowes Effectiveness of home or hospital initiation of treatment at diagnosis for children with type 1 diabetes (DECIDE trial): a multicentre individually randomised controlled trial BMJ Open |
| title | Effectiveness of home or hospital initiation of treatment at diagnosis for children with type 1 diabetes (DECIDE trial): a multicentre individually randomised controlled trial |
| title_full | Effectiveness of home or hospital initiation of treatment at diagnosis for children with type 1 diabetes (DECIDE trial): a multicentre individually randomised controlled trial |
| title_fullStr | Effectiveness of home or hospital initiation of treatment at diagnosis for children with type 1 diabetes (DECIDE trial): a multicentre individually randomised controlled trial |
| title_full_unstemmed | Effectiveness of home or hospital initiation of treatment at diagnosis for children with type 1 diabetes (DECIDE trial): a multicentre individually randomised controlled trial |
| title_short | Effectiveness of home or hospital initiation of treatment at diagnosis for children with type 1 diabetes (DECIDE trial): a multicentre individually randomised controlled trial |
| title_sort | effectiveness of home or hospital initiation of treatment at diagnosis for children with type 1 diabetes decide trial a multicentre individually randomised controlled trial |
| url | https://bmjopen.bmj.com/content/9/12/e032317.full |
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