Sexual dimorphism in basal and post stress parameters of neuro-endocrine-immune complex, metabolome, electrocardiogram, and gastric mucosa at rats
Introduction and aim. Previously, we found significant associations between sex index and a number of parameters of the neuro-endocrine-immune complex and metabolome. Therefore, the next goal was a detailed analysis of sexual dimorphism in these parameters in baseline and post stress situations....
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Kazimierz Wielki University
2024-08-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/57566 |
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| author | Oksana Fihura Mykhaylo Korda Ivan Klishch Sofiya Ruzhylo Oksana Melnyk Walery Zukow Roman Yanchij Alyona Vorobienko Oleksandr Plyska Dariya Popovych Igor Popovych |
| author_facet | Oksana Fihura Mykhaylo Korda Ivan Klishch Sofiya Ruzhylo Oksana Melnyk Walery Zukow Roman Yanchij Alyona Vorobienko Oleksandr Plyska Dariya Popovych Igor Popovych |
| author_sort | Oksana Fihura |
| collection | DOAJ |
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Introduction and aim. Previously, we found significant associations between sex index and a number of parameters of the neuro-endocrine-immune complex and metabolome. Therefore, the next goal was a detailed analysis of sexual dimorphism in these parameters in baseline and post stress situations.
Material and methods. The experiment conducted on the same 18 males and 20 females rats Wistar line. 10 animals remained intact and other rats after a week of tap water (n=10) or phytoadaptogen “Balm Truskavets’” (n=18) administration were exposed to water-immersion and restraint stress (WIRS). The next day after stressing, endocrine, immune and metabolic parameters as well as ECG and damage to gastric mucosa was recorded.
Results. By the method of discriminant analysis was selected 23 variables (4 endocrine, 6 immune, 9 metabolic as well as 4 markers of damage to gastric mucosa and myocardium) whose constellation is characteristic for each group. The distance between the centroids of the major discriminant root of intact females and males as a measure of sexual dimorphism is 16.2 units. Acute stress increases it in control rats to 23.4 units, and in pretreated with phytoadaptogen - up to 29.4 units. Acute stress increases the severity of sexual dimorphism also in relation to variables, information about which is condensed in the minor root - from 0.99 to 2.29 units, while preventive use of phytoadaptogen limits it to 1.63 units.
Conclusion. In intact rats, significant sex differences were found for a number of endocrine, immune, and metabolic variables, which increase under the influence of acute stress per se, and to an even greater extent against the background of preventive use of a phytoadaptogen.
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| format | Article |
| id | doaj-art-a43f1e04ef7748e497b94faab842c742 |
| institution | Kabale University |
| issn | 2391-8306 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Kazimierz Wielki University |
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| series | Journal of Education, Health and Sport |
| spelling | doaj-art-a43f1e04ef7748e497b94faab842c7422025-01-07T08:16:39ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062024-08-017210.12775/JEHS.2024.72.57566Sexual dimorphism in basal and post stress parameters of neuro-endocrine-immune complex, metabolome, electrocardiogram, and gastric mucosa at ratsOksana Fihura0https://orcid.org/0000-0002-5711-0484Mykhaylo Korda1https://orcid.org/0000-0003-0676-336XIvan Klishch2https://orcid.org/0000-0001-6226-4296Sofiya Ruzhylo3https://orcid.org/0000-0003-2944-8821Oksana Melnyk4https://orcid.org/0000-0001-7928-4760Walery Zukow5https://orcid.org/0000-0002-7675-6117Roman Yanchij6https://orcid.org/0000-0001-7129-7698Alyona Vorobienko7https://orcid.org/0009-0008-4982-1551Oleksandr Plyska8https://orcid.org/0000-0001-7002-7637Dariya Popovych9https://orcid.org/0000-0002-5142-2057Igor Popovych10https://orcid.org/0000-0002-5664-5591Ivan Franko State Pedagogical University, Drohobych, Ukraine, Bohomolets Institute of Physiology of National Academy of Sciences, Kyїv, UkraineIY Horbachevskyi National Medical University, Ternopil, UkraineIY Horbachevskyi National Medical University, Ternopil, UkraineIvan Franko State Pedagogical University, Drohobych, UkraineDanylo Halytskyi National Medical University, Lviv, UkraineNicolaus Copernicus University, Torun, PolandBohomolets Institute of Physiology of National Academy of Sciences, Kyїv, UkraineBohomolets Institute of Physiology of National Academy of Sciences, Kyїv, Ukraine, Mykhajlo Dragomanov Ukrainian State University, Kyїv, UkraineMykhajlo Dragomanov Ukrainian State University, Kyїv, UkraineIY Horbachevskyi National Medical University, Ternopil, UkraineBohomolets Institute of Physiology of National Academy of Sciences, Kyїv, Ukraine Introduction and aim. Previously, we found significant associations between sex index and a number of parameters of the neuro-endocrine-immune complex and metabolome. Therefore, the next goal was a detailed analysis of sexual dimorphism in these parameters in baseline and post stress situations. Material and methods. The experiment conducted on the same 18 males and 20 females rats Wistar line. 10 animals remained intact and other rats after a week of tap water (n=10) or phytoadaptogen “Balm Truskavets’” (n=18) administration were exposed to water-immersion and restraint stress (WIRS). The next day after stressing, endocrine, immune and metabolic parameters as well as ECG and damage to gastric mucosa was recorded. Results. By the method of discriminant analysis was selected 23 variables (4 endocrine, 6 immune, 9 metabolic as well as 4 markers of damage to gastric mucosa and myocardium) whose constellation is characteristic for each group. The distance between the centroids of the major discriminant root of intact females and males as a measure of sexual dimorphism is 16.2 units. Acute stress increases it in control rats to 23.4 units, and in pretreated with phytoadaptogen - up to 29.4 units. Acute stress increases the severity of sexual dimorphism also in relation to variables, information about which is condensed in the minor root - from 0.99 to 2.29 units, while preventive use of phytoadaptogen limits it to 1.63 units. Conclusion. In intact rats, significant sex differences were found for a number of endocrine, immune, and metabolic variables, which increase under the influence of acute stress per se, and to an even greater extent against the background of preventive use of a phytoadaptogen. https://apcz.umk.pl/JEHS/article/view/57566neuro-endocrine-immune complexmetabolomewater-immersion and restraint stressUkrainian phytocomposition “Balm Truskavets’”ratssexual dimorphism |
| spellingShingle | Oksana Fihura Mykhaylo Korda Ivan Klishch Sofiya Ruzhylo Oksana Melnyk Walery Zukow Roman Yanchij Alyona Vorobienko Oleksandr Plyska Dariya Popovych Igor Popovych Sexual dimorphism in basal and post stress parameters of neuro-endocrine-immune complex, metabolome, electrocardiogram, and gastric mucosa at rats Journal of Education, Health and Sport neuro-endocrine-immune complex metabolome water-immersion and restraint stress Ukrainian phytocomposition “Balm Truskavets’” rats sexual dimorphism |
| title | Sexual dimorphism in basal and post stress parameters of neuro-endocrine-immune complex, metabolome, electrocardiogram, and gastric mucosa at rats |
| title_full | Sexual dimorphism in basal and post stress parameters of neuro-endocrine-immune complex, metabolome, electrocardiogram, and gastric mucosa at rats |
| title_fullStr | Sexual dimorphism in basal and post stress parameters of neuro-endocrine-immune complex, metabolome, electrocardiogram, and gastric mucosa at rats |
| title_full_unstemmed | Sexual dimorphism in basal and post stress parameters of neuro-endocrine-immune complex, metabolome, electrocardiogram, and gastric mucosa at rats |
| title_short | Sexual dimorphism in basal and post stress parameters of neuro-endocrine-immune complex, metabolome, electrocardiogram, and gastric mucosa at rats |
| title_sort | sexual dimorphism in basal and post stress parameters of neuro endocrine immune complex metabolome electrocardiogram and gastric mucosa at rats |
| topic | neuro-endocrine-immune complex metabolome water-immersion and restraint stress Ukrainian phytocomposition “Balm Truskavets’” rats sexual dimorphism |
| url | https://apcz.umk.pl/JEHS/article/view/57566 |
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